Toward achromatic soft x-ray imaging system with sub-10-nm spatial resolution

Author(s):  
Satoru Egawa ◽  
Hidekazu Mimura
2018 ◽  
Vol 26 (24) ◽  
pp. 31290 ◽  
Author(s):  
Qianli Li ◽  
Xiaolin Liu ◽  
Mu Gu ◽  
Yahua Hu ◽  
Fengrui Li ◽  
...  

2016 ◽  
Vol 87 (11) ◽  
pp. 11E310 ◽  
Author(s):  
G. N. Hall ◽  
N. Izumi ◽  
O. L. Landen ◽  
R. Tommasini ◽  
J. P. Holder ◽  
...  

2019 ◽  
Vol 19 (07) ◽  
pp. 1940030 ◽  
Author(s):  
LUNG-FA PAN ◽  
KENG-YI WU ◽  
KE-LIN CHEN ◽  
SAMRIT KITTIPAYAK ◽  
LUNG-KWANG PAN

Objective: To optimize the minimum detectable difference (MDD) of a cardiac X-ray imaging system using the Taguchi L8(27) analysis and a precise line pair (LP) gauge. Methods: The optimal combination of the four critical factors of the cardiac X-ray imaging system, namely X-ray focus, kilovoltage (kVp), milliamper-seconds (mAs) and source image distance (SID), providing the MDD was calculated via the Taguchi analysis and experimentally verified. Two (low and high) levels were assigned for each factor, and eight combinations of four factors were used to acquire instant X-ray images using an NDT commercial LP gauge (with a gauge length of 64[Formula: see text]mm and a width of [Formula: see text][Formula: see text]mm). The latter had five lines and was split gradually from top to bottom for the inspection of X-ray images, whose quality was ranked by three well-trained radiologists according to the double-blind criterion. The ranking grade was given by sharp contrast, low noise and precision to distinguish the LP. Accordingly, the MDD was derived to represent the spatial resolution of instant X-ray images by the revised Student’s [Formula: see text]-test analysis. The optimal combination of factors was experimentally identified and clinically verified in the follow-up inspections. Results: For the conventional setting, Group No. 7 (which obtained the highest grade among eight groups) and the optimal setting, the obtained MDD values were [Formula: see text], [Formula: see text] and [Formula: see text][Formula: see text]mm, respectively, while the LP (line pair/mm) interpolated from the gauge scale amounted to [Formula: see text], [Formula: see text] and [Formula: see text][Formula: see text]LP/mm, respectively. Conclusion: The Taguchi L8 analysis was proved to be instrumental in optimizing the cardiac X-ray imaging system MDD and is recommended to be used jointly with the revised Student’s [Formula: see text]-test analysis for improving the spatial resolution of instant X-ray images.


2002 ◽  
Vol 41 (13) ◽  
pp. 2420 ◽  
Author(s):  
Fabrice Ouandji ◽  
Eric Potter ◽  
Wei R. Chen ◽  
Yuhua Li ◽  
David Tang ◽  
...  

2012 ◽  
Vol 20 (1) ◽  
pp. 153-159 ◽  
Author(s):  
Patrik Vagovič ◽  
Dušan Korytár ◽  
Angelica Cecilia ◽  
Elias Hamann ◽  
Libor Švéda ◽  
...  

The performance of a recently developed full-field X-ray micro-imaging system based on an in-line Bragg magnifier is reported. The system is composed of quasi-channel-cut crystals in combination with a Medipix single-photon-counting detector. A theoretical and experimental study of the imaging performance of the crystals–detector combination and a comparison with a standard indirect detector typically used in high-resolution X-ray imaging schemes are reported. The spatial resolution attained by our system is about 0.75 µm, limited only by the current magnification. Compared with an indirect detector system, this system features a better efficiency, signal-to-noise ratio and spatial resolution. The optimal working resolution range of this system is between ∼0.4 µm and 1 µm, filling the gap between transmission X-ray microscopes and indirect detectors. Applications for coherent full-field imaging of weakly absorbing samples are shown and discussed.


2021 ◽  
Vol 20 ◽  
pp. 153303382110101
Author(s):  
Thet-Thet Lwin ◽  
Akio Yoneyama ◽  
Hiroko Maruyama ◽  
Tohoru Takeda

Phase-contrast synchrotron-based X-ray imaging using an X-ray interferometer provides high sensitivity and high spatial resolution, and it has the ability to depict the fine morphological structures of biological soft tissues, including tumors. In this study, we quantitatively compared phase-contrast synchrotron-based X-ray computed tomography images and images of histopathological hematoxylin-eosin-stained sections of spontaneously occurring rat testicular tumors that contained different types of cells. The absolute densities measured on the phase-contrast synchrotron-based X-ray computed tomography images correlated well with the densities of the nuclear chromatin in the histological images, thereby demonstrating the ability of phase-contrast synchrotron-based X-ray imaging using an X-ray interferometer to reliably identify the characteristics of cancer cells within solid soft tissue tumors. In addition, 3-dimensional synchrotron-based phase-contrast X-ray computed tomography enables screening for different structures within tumors, such as solid, cystic, and fibrous tissues, and blood clots, from any direction and with a spatial resolution down to 26 μm. Thus, phase-contrast synchrotron-based X-ray imaging using an X-ray interferometer shows potential for being useful in preclinical cancer research by providing the ability to depict the characteristics of tumor cells and by offering 3-dimensional information capabilities.


Nanomaterials ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1721
Author(s):  
Heon Yong Jeong ◽  
Hyung San Lim ◽  
Ju Hyuk Lee ◽  
Jun Heo ◽  
Hyun Nam Kim ◽  
...  

The effect of scintillator particle size on high-resolution X-ray imaging was studied using zinc tungstate (ZnWO4) particles. The ZnWO4 particles were fabricated through a solid-state reaction between zinc oxide and tungsten oxide at various temperatures, producing particles with average sizes of 176.4 nm, 626.7 nm, and 2.127 μm; the zinc oxide and tungsten oxide were created using anodization. The spatial resolutions of high-resolution X-ray images, obtained from utilizing the fabricated particles, were determined: particles with the average size of 176.4 nm produced the highest spatial resolution. The results demonstrate that high spatial resolution can be obtained from ZnWO4 nanoparticle scintillators that minimize optical diffusion by having a particle size that is smaller than the emission wavelength.


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