SERS detection of some drugs using aluminum hydroxide with embedded copper nanoparticles

This report is dedicated to development of surface-enhanced Raman spectroscopy (SERS) based analysis protocol for detection of antibiotics in urine. The key step of the protocol is the pretreatment of urine before the detection to minimize background signal. The pretreatment includes extraction of intrinsic urine components using aluminum hydroxide gel (AHG) and further pH adjusting of the purified sample. The protocol was tested by detection of a single antibiotic in artificially spiked samples of real urine. Five antibiotics of cephalosporin class (cefazolin, cefoperazone, cefotaxime, ceftriaxone, and cefuroxime) were used for testing. SERS measurements were performed using a portable Raman spectrometer with 638 nm excitation wavelength and silver nanoparticles as SERS substrate. The calibration curves of four antibiotics (cefuroxime is the exception) cover the concentrations required for detection in patient’s urine during therapy (25/100‒500 μg/mL). Random error of the analysis (RSD < 20%) and limits of quantification (20‒90 μg/mL) for these antibiotics demonstrate the applicability of the protocol for reliable quantitative detection during therapeutic drug monitoring. The detection of cefuroxime using the protocol is not sensitive enough, allowing only for qualitative detection. Additionally, time stability and batch-to-batch reproducibility of AHG were studied and negative influence of the pretreatment protocol and its limitations were estimated and discussed.

Download Full-text

SERS detection of ceftriaxone and sulfadimethoxine using copper nanoparticles temporally protected by porous calcium carbonate

Microchimica Acta ◽

10.1007/s00604-018-3018-9 ◽

2018 ◽

Vol 185 (10) ◽

Cited By ~ 9

Author(s):

Natalia E. Markina ◽

Elena K. Volkova ◽

Andrey M. Zakharevich ◽

Irina Yu. Goryacheva ◽

Alexey V. Markin

Keyword(s):

Calcium Carbonate ◽

Copper Nanoparticles ◽

Sers Detection ◽

Porous Calcium Carbonate

Download Full-text

LASER-INDUCED INCANDESCENCE MEASUREMENTS OF SILICON AND COPPER NANOPARTICLES: SPECTROSCOPIC MODEL

Proceeding of Proceedings of the 8th International Symposium on Radiative Transfer, RAD-16 June 6-10,2016, Cappadocia, Turkey ◽

10.1615/rad-16.200 ◽

2016 ◽

Author(s):

Kyle J. Daun ◽

Jan Menser ◽

Raphael Mansmann ◽

Thomas Dreier ◽

Christof Schulz

Keyword(s):

Copper Nanoparticles ◽

Laser Induced Incandescence

Download Full-text

Some Properties and Structural Features of Poly(Vinyl Chloride)/Cu Films with Copper Nanoparticles Obtained by Exploding Wire Methodu

Journal of Nano- and Electronic Physics ◽

10.21272/jnep.12(4).04032 ◽

2020 ◽

Vol 12 (4) ◽

pp. 04032-1-04032-5

Author(s):

V. V. Krivtsov ◽

◽

V. V. Kukla ◽

V. V. Krivtsov ◽

A. I. Shidlovskiy ◽

...

Keyword(s):

Vinyl Chloride ◽

Copper Nanoparticles ◽

Structural Features ◽

Exploding Wire ◽

Cu Films ◽

Poly Vinyl Chloride

Download Full-text

Synthesis of 3,4-Dihydropyrano[c]chromenes Using Carbon Microsphere Supported Copper Nanoparticles (Cu-NP/C) Prepared from Loaded Cation Exchange Resin as a Catalyst

Current Organic Synthesis ◽

10.2174/1570179415666181116104931 ◽

2019 ◽

Vol 16 (2) ◽

pp. 288-293

Author(s):

Yogesh W. More ◽

Sunil U. Tekale ◽

Nitishkumar S. Kaminwar ◽

László Kótai ◽

Tibor Pasinszki ◽

...

Keyword(s):

Raman Spectroscopy ◽

Cation Exchange ◽

Copper Nanoparticles ◽

Exchange Resin ◽

Cation Exchange Resin ◽

Environmentally Benign ◽

High Yield ◽

Carbon Microsphere ◽

Catalytic Material ◽

Operational Simplicity

Aim and Objective: The present study was performed with the aim to develop an efficient and environmentally benign protocol for the synthesis of biologically siginifcant 3, 4-dihydropyrano[c]chromenes using a new catalytic material. The protocol involves the use of a reusable, environment friendly materials and solvents with operational simplicity. Materials and Methods: Carbon microsphere supported copper nanoparticles (Cu-NP/C) prepared from loaded cation exchange resin were synthesized, characterized with well versed analytical techniques such as XRD, SEM and Raman spectroscopy and the synthesized material was used as a catalyst for the environmentally benign synthesis of 3,4-dihydropyrano[c]chromenes. Results: The formation of carbon microsphere supported copper nanoparticles (Cu-NP/C) prepared from loaded cation exchange resin was confirmed by XRD, SEM and Raman spectroscopy which was employed as a heterogeneous material for the synthesis of 3,4-dihydropyrano[c]chromenes. The products formed were characterized by the analysis of spectroscopic data - NMR, IR and mass. The safe catalytic system offers several advantages including operational simplicity, environmental friendliness, high yield, and reusability of catalyst and green chemical transformation. Conclusion: Herein we report an easy and efficient protocol for the one-pot synthesis of dihydropyrano[ c]chromenes using environmentally benign MCR approach in ethanol as the green solvent. The method developed herein constitutes a valuable addition to the existing methods for the synthesis of titled compounds.

Download Full-text

Biogenic synthesis of copper nanoparticles from rose (Rosa indica L.) and their applications in photocatalytic degradation of Malachite Green and Carbol Fuchsin dyes

Nanoscience &Nanotechnology-Asia ◽

10.2174/2210681210999200801030056 ◽

2020 ◽

Vol 10 ◽

Author(s):

Manmeet Kaur ◽

Suman Prajapati ◽

Samneek Cholia ◽

Jaskeet Singh Mann ◽

Gurpreet Singh

Keyword(s):

Photocatalytic Degradation ◽

Malachite Green ◽

Copper Nanoparticles ◽

Dye Degradation ◽

Industrial Effluent ◽

Copper Nanoparticle ◽

Synthesis Of Nanoparticles ◽

Carbol Fuchsin ◽

Double Beam ◽

The Rose

Background: In the recent years, the green synthesis of nanoparticles has taken a lead role over the conventional chemical and physical approach due to its non-toxic, cost effective parameters and has found its place in various applications. Objectives: The major objectives of this study was to synthesise and characterize the copper nanoparticles using the rose extract at different set of conditions and analyse these nanoparticles as a source of dye degradation agent under sunlight conditions. Methods: Present study was conducted with the aim to synthesis the copper nanoparticle using the rose petal extract. The components present the in the extract act as the reduction and stabilization agents for the synthesis of CuNPs. The synthesized nanoparticles were characterized by using UV-VIS, FTIR, XRD and SEM analysis. Photocatalytic degradation of two dyes (Malachite Green and Carbol fuchsin) was analysed using double beam spectroscopic analysis Results: UV-Vis analysis indicated the presence of a peak at around 630 nm. The FT-IR analysis indicated the involvement of various biomolecules during the synthesis of nanoparticles. The structure and the conformation was elucidated using XRD and SEM showed the agglomerated form of the synthesized nanoparticles with the size range of about 60-90 nm. The synthesised copper nanoparticles was used for degradation of malachite green and carbol fuchsin dye using photocatalytic under sunlight irradiation. UV-Vis spectral analysis indicated that synthesised copper nanoparticle act more effective in degradation of malachite green (around 95%) whereas carbol fuchsin showed a maximum degradation by 52% therefore suggesting that CuNPs act as an efficient photo catalyst in dye degradation. Conclusion: The results obtained from this study indicates that rose extract has the potential of synthesis of copper nanoparticles which is non-toxic and convenient approach as compared to physical and chemical synthesis. These nanoparticles can be effectively employed as dye decolourization agents to treat industrial effluent and prevent the environmental pollution.

Download Full-text