In recent years, the agent technology has been successfully applied in supply chains, thanks to its excellent interactivity, proactivity, and autonomy. However, the existing research on multi-agent green supply chain (GSC) stops on the strategic and tactical levels, failing to implement the relevant supply chain models. To overcome the limitation, this paper designs a multi-agent GSC management system for retailers, with the aim to obtain scientific collaboration strategies among multiple agents and to make effective logistics decisions for the supply chain. Firstly, a 3-layer hierarchical evaluation index system (EIS) was established under the framework of the multi-agent GSC management system. Next, the authors modeled the supply-demand relationship and dynamic game of multi-agent GSC, and discussed the cooperation and negotiation models among multiple agents. Experimental results show that the proposed multi-agent GSC management model is highly effective. The research findings provide a reference for the application of multi-agent technology in other types of supply chain enterprises.