TH-E-ValB-06: Quantitative Characterization of Tumor Vascular Dysfunction in High-Grade Gliomas Prior to and During Radiotherapy

2006 ◽  
Vol 33 (6Part23) ◽  
pp. 2290-2290
Author(s):  
V Nagesh ◽  
T Chenevert ◽  
L Junck ◽  
C Tsien ◽  
T Lawrence ◽  
...  
Keyword(s):  
Vascular Dysfunction ◽  
High Grade ◽  
Quantitative Characterization ◽  
High Grade Gliomas

scholarly journals Quantitative characterization of hemodynamic properties and vasculature dysfunction of high-grade gliomas

2007 ◽  
Vol 20 (6) ◽  
pp. 566-577 ◽  
Author(s):  
Vijaya Nagesh ◽  
Thomas L. Chenevert ◽  
Christina I. Tsien ◽  
Brian D. Ross ◽  
Theodore S. Lawrence ◽  
...  
Keyword(s):  
High Grade ◽  
Quantitative Characterization ◽  
High Grade Gliomas

scholarly journals Applications of Radiomics and Radiogenomics in High-Grade Gliomas in the Era of Precision Medicine

Cancers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 5921
Author(s):  
Anahita Fathi Kazerooni ◽  
Stephen J. Bagley ◽  
Hamed Akbari ◽  
Sanjay Saxena ◽  
Sina Bagheri ◽  
...  
Keyword(s):  
Tumor Recurrence ◽  
Extent Of Resection ◽  
Target Area ◽  
High Grade ◽  
Future Directions ◽  
Mri Scans ◽  
High Grade Gliomas ◽  
Changes Over Time

Machine learning (ML) integrated with medical imaging has introduced new perspectives in precision diagnostics of high-grade gliomas, through radiomics and radiogenomics. This has raised hopes for characterizing noninvasive and in vivo biomarkers for prediction of patient survival, tumor recurrence, and genomics and therefore encouraging treatments tailored to individualized needs. Characterization of tumor infiltration based on pre-operative multi-parametric magnetic resonance imaging (MP-MRI) scans may allow prediction of the loci of future tumor recurrence and thereby aid in planning the course of treatment for the patients, such as optimizing the extent of resection and the dose and target area of radiation. Imaging signatures of tumor genomics can help in identifying the patients who benefit from certain targeted therapies. Specifying molecular properties of gliomas and prediction of their changes over time and with treatment would allow optimization of treatment. In this article, we provide neuro-oncology, neuropathology, and computational perspectives on the promise of radiomics and radiogenomics for allowing personalized treatments of patients with gliomas and discuss the challenges and limitations of these methods in multi-institutional clinical trials and suggestions to mitigate the issues and the future directions.

scholarly journals Characterization of the serum metabolome following radiation treatment in patients with high-grade gliomas

2016 ◽  
Vol 11 (1) ◽  
Author(s):  
Lina Mörén ◽  
Carl Wibom ◽  
Per Bergström ◽  
Mikael Johansson ◽  
Henrik Antti ◽  
...  
Keyword(s):  
Radiation Treatment ◽  
High Grade ◽  
High Grade Gliomas

scholarly journals Characterization of the transcriptional and metabolic responses of pediatric high grade gliomas to mTOR-HIF-1α axis inhibition

Oncotarget ◽  
2017 ◽  
Vol 8 (42) ◽  
pp. 71597-71617 ◽  
Author(s):  
Aurélia Nguyen ◽  
François Marie Moussallieh ◽  
Alan Mackay ◽  
A. Ercument Cicek ◽  
Andres Coca ◽  
...  
Keyword(s):  
Metabolic Responses ◽  
High Grade ◽  
High Grade Gliomas

scholarly journals Fusion Genes Altered in Adult Malignant Gliomas

2021 ◽  
Vol 12 ◽  
Author(s):  
Gan You ◽  
Xing Fan ◽  
Huimin Hu ◽  
Tao Jiang ◽  
Clark C. Chen
Keyword(s):  
Genetic Background ◽  
Molecular Genetic ◽  
Malignant Gliomas ◽  
Therapeutic Targets ◽  
High Grade ◽  
Gene Fusions ◽  
Fusion Genes ◽  
High Grade Gliomas ◽  
The Many

Malignant gliomas are highly heterogeneous brain tumors in molecular genetic background. Despite the many recent advances in the understanding of this disease, patients with adult high-grade gliomas retain a notoriously poor prognosis. Fusions involving oncogenes have been reported in gliomas and may serve as novel therapeutic targets to date. Understanding the gene fusions and how they regulate oncogenesis and malignant progression will contribute to explore new approaches for personalized treatment. By now, studies on gene fusions in gliomas remain limited. However, some current clinical trials targeting fusion genes have presented exciting preliminary findings. The aim of this review is to summarize all the reported fusion genes in high-grade gliomas so far, discuss the characterization of some of the most popular gene fusions occurring in malignant gliomas, as well as their function in tumorigenesis, and the underlying clinical implication as therapeutic targets.

scholarly journals GENE-15. CHARACTERIZATION OF DIFFERENTIAL 5-HYDROXYMETHYLCYTOSINE IN IDH1 MUTANT VERSUS IDH1 WILD-TYPE HIGH-GRADE GLIOMAS

2017 ◽  
Vol 19 (suppl_6) ◽  
pp. vi95-vi95
Author(s):  
Wioletta Glowacka ◽  
Harshika Jain ◽  
Makiko Okura ◽  
Abulizi Maimaitiming ◽  
Mamatjan Yasin ◽  
...  
Keyword(s):  
High Grade ◽  
Wild Type ◽  
High Grade Gliomas

Characterization of fenofibrate-mediated anti-proliferative pro-apoptotic effects on high-grade gliomas and anti-invasive effects on glioma stem cells

2014 ◽  
Vol 117 (2) ◽  
pp. 225-234 ◽  
Author(s):  
Emanuela Binello ◽  
Elisabetta Mormone ◽  
Luni Emdad ◽  
Harini Kothari ◽  
Isabelle M. Germano
Keyword(s):  
Stem Cells ◽  
Glioma Stem Cells ◽  
High Grade ◽  
High Grade Gliomas ◽  
Apoptotic Effects

Genetic Characterization of Stromal Cells in High Grade Gliomas

2017 ◽  
Vol 99 (2) ◽  
pp. E68
Author(s):  
S. Choi ◽  
J. Hayes ◽  
S. Shelton ◽  
L. Jones ◽  
T. Mazor ◽  
...  
Keyword(s):  
Stromal Cells ◽  
Genetic Characterization ◽  
High Grade ◽  
High Grade Gliomas

Venous Thromboembolism and High Grade Gliomas

1993 ◽  
Vol 70 (03) ◽  
pp. 393-396 ◽  
Author(s):  
Mandeep S Dhami ◽  
Robert D Bona ◽  
John A Calogero ◽  
Richard M Hellman
Keyword(s):  
Risk Factors ◽  
Venous Thromboembolism ◽  
Medical Center ◽  
Significant Risk ◽  
Bleeding Complications ◽  
Fisher Exact Test ◽  
High Grade ◽  
Chi Square ◽  
Exact Test ◽  
High Grade Gliomas

SummaryA retrospective study was done to determine the incidence of and the risk factors predisposing to clinical venous thromboembolism (VTE) in patients treated for high grade gliomas. Medical records of 68 consecutive patients diagnosed and treated at Saint Francis Hospital and Medical Center from January 1986 to June 1991 were reviewed. The follow up was to time of death or at least 6 months (up to December 1991). All clinically suspected episodes of VTE were confirmed by objective tests. Sixteen episodes of VTE were detected in 13 patients for an overall episode rate of 23.5%. Administration of chemotherapy (p = 0.027, two tailed Fisher exact test) and presence of paresis (p = 0.031, two tailed Fisher exact test) were statistically significant risk factors for the development of VTE. Thrombotic events were more likely to occur in the paretic limb and this difference was statistically significant (p = 0.00049, chi square test, with Yates correction). No major bleeding complications were seen in the nine episodes treated with long term anticoagulation.We conclude that venous thromboembolic complications are frequently encountered in patients being treated for high grade gliomas and the presence of paresis and the administration of chemotherapy increases the risk of such complications.

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