scholarly journals Study on ultrasound sequence with scanning the focus to generate reactive oxygen species efficiently for sonodynamic therapy

2017 ◽  
Author(s):  
Shinya Nishitaka ◽  
Daisaku Mashiko ◽  
Ryosuke Iwasaki ◽  
Shin Yoshizawa ◽  
Shin-ichiro Umemura
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Sonodynamic Therapy

scholarly journals Mechanisms of Reactive Oxygen Species Generated by Inorganic Nanomaterials for Cancer Therapeutics

2021 ◽  
Vol 9 ◽  
Author(s):  
Lizhen Zhang ◽  
Chengyuan Zhu ◽  
Rongtao Huang ◽  
Yanwen Ding ◽  
Changping Ruan ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Biomedical Applications ◽  
Reactive Oxygen ◽  
Cancer Therapeutics ◽  
Surface Characteristics ◽  
Oxygen Species ◽  
Sonodynamic Therapy ◽  
Dynamic Therapy ◽  
Inorganic Nanomaterials ◽  
Generation Mechanisms

Recently, inorganic nanomaterials have received considerable attention for use in biomedical applications owing to their unique physicochemical properties based on their shapes, sizes, and surface characteristics. Photodynamic therapy (PDT), sonodynamic therapy (SDT), and chemical dynamic therapy (CDT), which are cancer therapeutics mediated by reactive oxygen species (ROS), have the potential to significantly enhance the therapeutic precision and efficacy for cancer. To facilitate cancer therapeutics, numerous inorganic nanomaterials have been developed to generate ROS. This mini review provides an overview of the generation mechanisms of ROS by representative inorganic nanomaterials for cancer therapeutics, including the structures of engineered inorganic nanomaterials, ROS production conditions, ROS types, and the applications of the inorganic nanomaterials in cancer PDT, SDT, and CDT.

scholarly journals Reactive Oxygen Species-Based Nanomaterials for Cancer Therapy

2021 ◽  
Vol 9 ◽  
Author(s):  
Yingbo Li ◽  
Jie Yang ◽  
Xilin Sun
Keyword(s):  
Reactive Oxygen Species ◽  
Cancer Therapy ◽  
Tumor Cells ◽  
Biomedical Applications ◽  
Reactive Oxygen ◽  
Redox Balance ◽  
Oxygen Species ◽  
Sonodynamic Therapy ◽  
Organic Nanomaterials ◽  
Trigger Cell Death

Nanotechnology advances in cancer therapy applications have led to the development of nanomaterials that generate cytotoxic reactive oxygen species (ROS) specifically in tumor cells. ROS act as a double-edged sword, as they can promote tumorigenesis and proliferation but also trigger cell death by enhancing intracellular oxidative stress. Various nanomaterials function by increasing ROS production in tumor cells and thereby disturbing their redox balance, leading to lipid peroxidation, and oxidative damage of DNA and proteins. In this review, we outline these mechanisms, summarize recent progress in ROS-based nanomaterials, including metal-based nanoparticles, organic nanomaterials, and chemotherapy drug-loaded nanoplatforms, and highlight their biomedical applications in cancer therapy as drug delivery systems (DDSs) or in combination with chemodynamic therapy (CDT), photodynamic therapy (PDT), or sonodynamic therapy (SDT). Finally, we discuss the advantages and limitations of current ROS-mediated nanomaterials used in cancer therapy and speculate on the future progress of this nanotechnology for oncological applications.

scholarly journals Effect of ClAlPcS2 photodynamic and sonodynamic therapy on hela cells

2019 ◽  
pp. S375-S384 ◽  
Author(s):  
S. Binder ◽  
B Hosikova ◽  
Z. Mala ◽  
L. Zarska ◽  
H. Kolarova
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Hela Cells ◽  
Cell Damage ◽  
Combined Therapy ◽  
Reactive Oxygen ◽  
Ros Production ◽  
Oxygen Species ◽  
Sonodynamic Therapy ◽  
A Cell

Photodynamic therapy (PDT) uses photosensitive substance to provoke a cytotoxic reaction causing a cell damage or cell death. The substances, photosensitizers, are usually derivates of porphyrine or phtalocyanine. Photosensitizers must be activated by light in order to produce reactive oxygen species, mainly singlet oxygen. Sonodynamic therapy (SDT) utilizes ultrasound to enhance a cytotoxic effects of compounds called sonosensitizers. In this study we investigated photodynamic and sonodynamic effect of chloraluminium phtalocyanine disulfonate (ClAlPcS(2)) on HeLa cells. DNA damage, cell viability and reactive oxygen species (ROS) production were assessed to find whether the combination of PDT and SDT inflicts HeLa cells more than PDT alone. We found that the combined therapy increases DNA fragmentation, enhances ROS production and decreases cell survival. Our results indicate that ClAlPcS(2) can act as a sonosentitiser and combined with PDT causes more irreversible changes to the cells resulting in cell death than PDT alone.

scholarly journals SWCNT–porphyrin nano-hybrids selectively activated by ultrasound: an interesting model for sonodynamic applications

RSC Advances ◽  
2020 ◽  
Vol 10 (37) ◽  
pp. 21736-21744 ◽  
Author(s):  
Federica Bosca ◽  
Ingrid Corazzari ◽  
Federica Foglietta ◽  
Roberto Canaparo ◽  
Gianni Durando ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Reactive Oxygen ◽  
Acoustic Cavitation ◽  
Oxygen Species ◽  
Sonodynamic Therapy

Sonodynamic therapy (SDT) is an innovative anticancer approach, based on the excitation of a given molecule (usually a porphyrin) by inertial acoustic cavitation that leads to cell death via the production of reactive oxygen species (ROS).

scholarly journals ROS-Dependent Activation of Autophagy through the PI3K/Akt/mTOR Pathway Is Induced by Hydroxysafflor Yellow A-Sonodynamic Therapy in THP-1 Macrophages

2017 ◽  
Vol 2017 ◽  
pp. 1-16 ◽  
Author(s):  
Yueqing Jiang ◽  
Jiayuan Kou ◽  
Xiaobo Han ◽  
Xuesong Li ◽  
Zhaoyu Zhong ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Inflammatory Responses ◽  
Reactive Oxygen ◽  
Inflammatory Factors ◽  
Oxygen Species ◽  
Hydroxysafflor Yellow A ◽  
Akt Inhibitor ◽  
Sonodynamic Therapy ◽  
Inflammatory Reactions ◽  
Acetyl Cysteine

Monocyte-derived macrophages participate in infaust inflammatory responses by secreting various types of proinflammatory factors, resulting in further inflammatory reactions in atherosclerotic plaques. Autophagy plays an important role in inhibiting inflammation; thus, increasing autophagy may be a therapeutic strategy for atherosclerosis. In the present study, hydroxysafflor yellow A-mediated sonodynamic therapy was used to induce autophagy and inhibit inflammation in THP-1 macrophages. Following hydroxysafflor yellow A-mediated sonodynamic therapy, autophagy was induced as shown by the conversion of LC3-II/LC3-I, increased expression of beclin 1, degradation of p62, and the formation of autophagic vacuoles. In addition, inflammatory factors were inhibited. These effects were blocked by Atg5 siRNA, the autophagy inhibitor 3-methyladenine, and the reactive oxygen species scavenger N-acetyl cysteine. Moreover, AKT phosphorylation at Ser473 and mTOR phosphorylation at Ser2448 decreased significantly after HSYA-SDT. These effects were inhibited by the PI3K inhibitor LY294002, the AKT inhibitor triciribine, the mTOR inhibitor rapamycin, mTOR siRNA, and N-acetyl cysteine. Our results demonstrate that HSYA-SDT induces an autophagic response via the PI3K/Akt/mTOR signaling pathway and inhibits inflammation by reactive oxygen species in THP-1 macrophages.

scholarly journals P-P11 A tumour responsive, oxygen-generating nanoparticle to combat hypoxia in pancreatic tumours

2021 ◽  
Vol 108 (Supplement_9) ◽  
Author(s):  
Sian Farrell ◽  
Dean Nicholas ◽  
Heather Nesbitt ◽  
Keiran Logan ◽  
Eva McMullin ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Pancreatic Cancer ◽  
Photodynamic Therapy ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Therapeutic Approaches ◽  
Sonodynamic Therapy ◽  
Oxygen Generation ◽  
Pancreatic Tumours ◽  
Pancreatic Tumour

Abstract Background Pancreatic cancer remains a significant therapeutic challenge and its poor prognosis has remained relatively unchanged for the past 40 years.    Pancreatic tumours are highly desmoplastic and impenetrable lesions in which both gas and mass transfer is severely compromised.   This leads to the development of hypoxia within the tumour and this compromises therapeutic approaches that rely on cytotoxic reactive oxygen species, e.g. photodynamic therapy, sonodynamic therapy and radiotherapy.     Hypoxia also results in a relatively low pH within the tumour microenvironment.  Here we describe a pH sensitive nanoparticle that can generate oxygen in the tumour and enhance ROS generating therapeutic approaches. Methods CaO2 NPs were generated by exposing to low frequency ultrasound and subsequently coated using a polymethacrylate polymer that becomes soluble at pH 6.4.   For some studies, the sonosensitiser, Rose Bengal was attached to the particles.   Oxygen generation in tumours (BxPC3) was demonstrated by inserting a dissolved oxygen probe into tumours following IV administration of particles.  Particles were also employed together with photodynamic therapy (PDT) and sonodynamic therapy (SDT) using human xenograft and syngeneic pancreatic tumour models.  In some cases, tumour tissues were recovered and analysed for tumour infiltrating immune cells using flow cytometry. Results Conclusions Coating CaO2 nanoparticles with a pH sensitive polymer provides in situ oxygen generation in tumours. Transient provision of oxygen enhances therapies that depend on the generation of cytotoxic reactive oxygen species. When used with SDT, and using a bilateral syngeneic pancreatic tumour model, a powerful abscopal effect was observed and this was shown to be immune-mediated. The above data suggest that the particles may be exploited to enhance other therapies that depend on the generation of ROS, e.g. radiotherapy, and further suggest that the approach can be used to treat either local or disseminated forms of pancreatic cancer.

A mitochondria-targeted anticancer nanoplatform with deep penetration for enhanced synergistic sonodynamic and starvation therapy

2020 ◽  
Vol 8 (16) ◽  
pp. 4581-4594 ◽  
Author(s):  
Ruo Zhang ◽  
Liang Zhang ◽  
Haitao Ran ◽  
Pan Li ◽  
Ju Huang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Tumor Cells ◽  
Reactive Oxygen ◽  
Deep Penetration ◽  
Oxygen Species ◽  
Sonodynamic Therapy ◽  
Induced Apoptosis

Sonodynamic therapy (SDT), as an emerging technique, gives rise to reactive oxygen species (ROS)-induced apoptosis of tumor cells.

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