scholarly journals The NIH Common Fund/Roadmap Epigenomics Program: Successes of a comprehensive consortium

2019 ◽  
Vol 5 (7) ◽  
pp. eaaw6507 ◽  
Author(s):  
John S. Satterlee ◽  
Lisa H. Chadwick ◽  
Frederick L. Tyson ◽  
Kim McAllister ◽  
Jill Beaver ◽  
...  
Keyword(s):  
Lessons Learned ◽  
Human Diseases ◽  
Human Tissues ◽  
Epigenetic Marks ◽  
Common Fund ◽  
Nih Roadmap ◽  
Tools And Methods

The NIH Roadmap Epigenomics Program was launched to deliver reference epigenomic data from human tissues and cells, develop tools and methods for analyzing the epigenome, discover novel epigenetic marks, develop methods to manipulate the epigenome, and determine epigenetic contributions to diverse human diseases. Here, we comment on the outcomes from this program: the scientific contributions made possible by a consortium approach and the challenges, benefits, and lessons learned from this group science effort.

scholarly journals Moving from formative research to co-creation of interventions: insights from a community health system project in Mozambique, Nepal and Peru

2018 ◽  
Vol 3 (6) ◽  
pp. e001183 ◽  
Author(s):  
David Beran ◽  
Maria Lazo-Porras ◽  
Maria Kathia Cardenas ◽  
François Chappuis ◽  
Albertino Damasceno ◽  
...  
Keyword(s):  
Global Health ◽  
Health System ◽  
Community Health ◽  
Neglected Tropical Diseases ◽  
Formative Research ◽  
Lessons Learned ◽  
Delivery Of Care ◽  
Health Project ◽  
System Project ◽  
Tools And Methods

Different methodological approaches for implementation research in global health focusing on how interventions are developed, implemented and evaluated are needed. In this paper, we detail the approach developed and implemented in the COmmunity HEalth System InnovatiON (COHESION) Project, a global health project aimed at strengthening health systems in Mozambique, Nepal and Peru. This project developed innovative formative research at policy, health system and community levels to gain a comprehensive understanding of the barriers, enablers, needs and lessons for the management of chronic disease using non-communicable and neglected tropical diseases as tracer conditions. After formative research, COHESION adopted a co-creation approach in the planning of interventions. The approach included two interactions with each type of stakeholder at policy, health system and community level in each country which aimed to develop interventions to improve the delivery of care of the tracer conditions. Diverse tools and methods were used in order to prioritise interventions based on support, resources and impact. Additionally, a COHESION score that assessed feasibility, sustainability and scaling up was used to select three potential interventions. Next steps for the COHESION Project are to further detail and develop the interventions propositioned through this process. Besides providing some useful tools and methods, this work also highlights the challenges and lessons learned from such an approach.

scholarly journals Teaching in Times of COVID-19 Pandemic in Two Peripheral Greek Universities: Lessons Learned from Students’ Experiences and Opinions

2020 ◽  
pp. 135-143
Author(s):  
Natassa Raikou ◽  
Chris Kaltsidis ◽  
Katerina Kedraka ◽  
Thanassis Karalis
Keyword(s):  
Higher Education ◽  
Lessons Learned ◽  
Economic Life ◽  
Digital Tools ◽  
Learning Engagement ◽  
Level Of Education ◽  
Interactive Tools ◽  
The Everyday ◽  
Regional Universities ◽  
Tools And Methods

COVID-19 pandemic has affected many aspects of social and economic life, including the educational sector. While each level of education faces its unique challenges, for the Higher Education the pandemic may act as the catalyst triggering a learning revolution. In the current study, which took place in April-May 2020, in the middle of lockdown in Greece, students from two regional Universities in Greece who participated pointed out that the Covid-19 pandemic disturbed their studies, even though their institutions managed to turn very quickly and successfully to distance learning. Despite the fact they are both old enough to handle the online work and technologically savvy enough to navigate new, digital tools and methods, a lot of anxiety, doubts and concerns arose. The main finding is that Greek students found it difficult to handle the lack of the everyday campus life and interaction with their fellow students and teachers, a lesson learnt for faculty to add pedagogically interactive tools, experiences, and ideas to stimulate students’ learning engagement.

scholarly journals Molecular Aspects and Prognostic Significance of Microcalcifications in Human Pathology: A Narrative Review

2020 ◽  
Vol 22 (1) ◽  
pp. 120
Author(s):  
Rita Bonfiglio ◽  
Annarita Granaglia ◽  
Raffaella Giocondo ◽  
Manuel Scimeca ◽  
Elena Bonanno
Keyword(s):  
Molecular Mechanisms ◽  
Prognostic Significance ◽  
Molecular Data ◽  
Narrative Review ◽  
Human Diseases ◽  
Imaging Biomarkers ◽  
Human Tissues ◽  
Associated Lesions ◽  
Human Pathology ◽  
Calcium Deposits

The presence of calcium deposits in human lesions is largely used as imaging biomarkers of human diseases such as breast cancer. Indeed, the presence of micro- or macrocalcifications is frequently associated with the development of both benign and malignant lesions. Nevertheless, the molecular mechanisms involved in the formation of these calcium deposits, as well as the prognostic significance of their presence in human tissues, have not been completely elucidated. Therefore, a better characterization of the biological process related to the formation of calcifications in different tissues and organs, as well as the understanding of the prognostic significance of the presence of these calcium deposits into human tissues could significantly improve the management of patients characterized by microcalcifications associated lesions. Starting from these considerations, this narrative review highlights the most recent histopathological and molecular data concerning the formation of calcifications in breast, thyroid, lung, and ovarian diseases. Evidence reported here could deeply change the current point of view concerning the role of ectopic calcifications in the progression of human diseases and also in the patients’ management. In fact, the presence of calcifications can suggest an unfavorable prognosis due to dysregulation of normal tissues homeostasis.

scholarly journals Teaching in Times of COVID-19 Pandemic in Two Peripheral Greek Universities: Lessons Learned from Students’ Experiences and Opinions

2020 ◽  
Vol 3 (1) ◽  
pp. 24-35
Author(s):  
Natassa Raikou ◽  
Chris Kaltsidis ◽  
Katerina Kedraka ◽  
Thanassis Karalis
Keyword(s):  
Higher Education ◽  
Lessons Learned ◽  
Economic Life ◽  
Digital Tools ◽  
Learning Engagement ◽  
Level Of Education ◽  
Interactive Tools ◽  
The Everyday ◽  
Regional Universities ◽  
Tools And Methods

COVID-19 pandemic has affected many aspects of social and economic life, including the educational sector. While each level of education faces its unique challenges, for the Higher Education the pandemic may act as the catalyst triggering a learning revolution. In the current study, which took place in April-May 2020, in the middle of lockdown in Greece, students from two regional Universities in Greece who participated pointed out that the Covid-19 pandemic disturbed their studies, even though their institutions managed to turn very quickly and successfully to distance learning. Despite the fact they are both old enough to handle the online work and technologically savvy enough to navigate new, digital tools and methods, a lot of anxiety, doubts and concerns arose. The main finding is that Greek students found it difficult to handle the lack of the everyday campus life and interaction with their fellow students and teachers, a lesson learnt for faculty to add pedagogically interactive tools, experiences, and ideas to stimulate students‟ learning engagement.

scholarly journals Validation of antibodies: Lessons learned from the Common Fund Protein Capture Reagents Program

2021 ◽  
Vol 7 (46) ◽  
Author(s):  
Ananda L. Roy ◽  
Elizabeth L. Wilder ◽  
James M. Anderson
Keyword(s):  
Lessons Learned ◽  
Common Fund ◽  
Protein Capture ◽  
The Common

scholarly journals NIH Roadmap/Common Fund at 10 years

Science ◽  
2014 ◽  
Vol 345 (6194) ◽  
pp. 274-276 ◽  
Author(s):  
F. S. Collins ◽  
E. L. Wilder ◽  
E. Zerhouni
Keyword(s):  
Common Fund ◽  
Nih Roadmap

scholarly journals An Overview of COVID-19 Vaccine Safety and Post-marketing Surveillance Systems

2021 ◽  
Vol 12 (4) ◽  
pp. 8
Author(s):  
Manal Mohammed Younus ◽  
Ali Azeez Al-Jumaili
Keyword(s):  
Safety Monitoring ◽  
Vaccine Safety ◽  
Lessons Learned ◽  
Surveillance Systems ◽  
Real World Data ◽  
Post Marketing Surveillance ◽  
The World ◽  
Post Marketing ◽  
Data Surveillance ◽  
Tools And Methods

The need for the safety monitoring of the COVID-19 vaccine is unprecedented. It is an ongoing process starting from different phases of clinical trials and continued to post-marketing to tackle the emergency used authorized COVID-19 vaccines across the world. Rapid detection, exchange, prioritization, and assessment of safety signals based on available real-world data, surveillance of Adverse events following immunization (AEFI), and adverse event of special interest (AESI) by studying the observed/expected cases. Enhanced collaboration, and availability of resources, tools, and methods will add to the lessons learned from previous experiences.

Experimental Amyloidosis Induced by Immune Complex

1971 ◽  
Vol 29 ◽  
pp. 582-583
Author(s):  
A. Kawaoi
Keyword(s):  
Immune Complex ◽  
Systemic Amyloidosis ◽  
Human Diseases ◽  
Experimental Amyloidosis ◽  
Freund’S Complete Adjuvant ◽  
Freund's Complete Adjuvant ◽  
Immunological Approach ◽  
Experimentally Induced

Numbers of immunological approach have been made to the amyloidosis through the variety of predisposing human diseases and the experimentally induced animals by the greater number of agents. The results suggest an important role of impaired immunity involving both humoral and cell-mediated aspects.Recently the author has succeeded in producing amyloidosis in the rabbits and mice by the injections of immune complex of heat denatured DNA.The aim of this report is to demonstrate the details of the ultrastructure of the amyloidosis induced by heterologous insoluble immune complex. Eleven of twelve mice, dd strain, subcutaneously injected twice a week with Freund's complete adjuvant and four of seven animals intraperitonially injected developed systemic amyloidosis two months later from the initial injections. The spleens were electron microscopically observed.

Sign in / Sign up

Export Citation Format

Share Document