scholarly journals Cell size is a determinant of stem cell potential during aging

2021 ◽  
Vol 7 (46) ◽  
Author(s):  
Jette Lengefeld ◽  
Chia-Wei Cheng ◽  
Pema Maretich ◽  
Marguerite Blair ◽  
Hannah Hagen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Size ◽  
Cell Potential ◽  
Stem Cell Potential

scholarly journals Cell size is a determinant of stem cell potential during aging

2020 ◽  
Author(s):  
Jette Lengefeld ◽  
Chia-Wei Cheng ◽  
Pema Maretich ◽  
Marguerite Blair ◽  
Hannah Hagen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Size ◽  
Cell Function ◽  
Cell Aging ◽  
Proliferative Potential ◽  
Cell Potential ◽  
Hematopoietic Stem ◽  
Stem Cell Potential

AbstractStem cells are remarkably small in size. Whether small size is important for stem cell function is unknown. We find that murine hematopoietic stem cells (HSCs) enlarge under conditions known to decrease stem cell function. This decreased fitness of large HSCs is due to reduced proliferative potential. Preventing HSC enlargement by inhibiting macromolecule biosynthesis or reducing large HSCs size by shortening G1 averts the loss of stem cell potential under conditions causing stem cell exhaustion. Finally, we show that a fraction of murine and human HSCs enlarge during aging. Preventing this age-dependent enlargement improves HSC function. We conclude that small cell size is important for stem cell function in vivo and propose that stem cell enlargement contributes to their functional decline during aging.One Sentence SummarySize increase drives stem cell aging.

scholarly journals Canine Mesenchymal Stem Cell Potential and the Importance of Dog Breed: Implication for Cell-Based Therapies

2015 ◽  
Vol 24 (10) ◽  
pp. 1969-1980 ◽  
Author(s):  
Alessandro Bertolo ◽  
Frank Steffen ◽  
Cherry Malonzo-Marty ◽  
Jivko Stoyanov
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Potential ◽  
Dog Breed ◽  
Stem Cell Potential

P-glycoprotein expression and stem cell potential

2000 ◽  
Vol 28 (7) ◽  
pp. 68-69
Author(s):  
Fiona Spratt ◽  
Suzanne Micallef ◽  
Brenda Williams ◽  
Michele Cook ◽  
Ivan Bertoncello
Keyword(s):  
Stem Cell ◽  
Cell Potential ◽  
P Glycoprotein ◽  
Stem Cell Potential

Effect of cold storage and cryopreservation of immature non-human primate testicular tissue on spermatogonial stem cell potential in xenografts

2006 ◽  
Vol 22 (4) ◽  
pp. 1060-1067 ◽  
Author(s):  
Kirsi Jahnukainen ◽  
Jens Ehmcke ◽  
Scott D. Hergenrother ◽  
Stefan Schlatt
Keyword(s):  
Stem Cell ◽  
Cold Storage ◽  
Testicular Tissue ◽  
Spermatogonial Stem Cell ◽  
Cell Potential ◽  
Stem Cell Potential ◽  
Human Primate

Amniotic Fluid‐Derived Stem Cell Potential for Therapeutic and Surgical Use: A Review of the Literature

2022 ◽  
Author(s):  
Caroline Baughn ◽  
Stephani Campion ◽  
Samer Elbabaa
Keyword(s):  
Stem Cell ◽  
Amniotic Fluid ◽  
Review Of The Literature ◽  
Cell Potential ◽  
Stem Cell Potential

Bone marrow mesenchymal stromal cells can support proliferative fraction of multiple myeloma cells with exhausted stem cell potential

2021 ◽  
Author(s):  
J Ilic ◽  
B Schlierf ◽  
M Rudert ◽  
R Ebert ◽  
M Herrmann ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Stem Cell ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Cell Potential ◽  
Myeloma Cells ◽  
Stem Cell Potential

scholarly journals Imatinib-mesylate enhances the maintenance of chronic myeloid leukemia stem cell potential in the absence of glucose

2018 ◽  
Vol 28 ◽  
pp. 33-38 ◽  
Author(s):  
Silvia Bono ◽  
Persio Dello Sbarba ◽  
Matteo Lulli
Keyword(s):  
Stem Cell ◽  
Chronic Myeloid Leukemia ◽  
Imatinib Mesylate ◽  
Myeloid Leukemia ◽  
Cell Potential ◽  
Leukemia Stem Cell ◽  
Stem Cell Potential

scholarly journals iPSC-Derived MSCs Versus Originating Jaw Periosteal Cells: Comparison of Resulting Phenotype and Stem Cell Potential

2020 ◽  
Vol 21 (2) ◽  
pp. 587 ◽  
Author(s):  
Felix Umrath ◽  
Marbod Weber ◽  
Siegmar Reinert ◽  
Hans-Peter Wendel ◽  
Meltem Avci-Adali ◽  
...  
Keyword(s):  
Stem Cell ◽  
Progenitor Cells ◽  
Induced Pluripotent Stem Cell ◽  
Mitochondrial Activity ◽  
Cell Potential ◽  
Differentiation Potential ◽  
Periosteal Cells ◽  
Induced Pluripotent ◽  
Stem Cell Potential ◽  
Promising Source

Induced pluripotent stem cell-derived mesenchymal stem cell-like cells (iMSCs) are considered to be a promising source of progenitor cells for approaches in the field of bone regeneration. In a previous study, we described the generation of footprint-free induced pluripotent stem cells (iPSCs) from human jaw periosteal cells (JPCs) by transfection of a self-replicating RNA (srRNA) and subsequent differentiation into functional osteogenic progenitor cells. In order to facilitate the prospective transfer into clinical practice, xeno-free reprogramming and differentiation methods were established. In this study, we compared the properties and stem cell potential of the iMSCs produced from JPC-derived iPSCs with the parental primary JPCs they were generated from. Our results demonstrated, on the one hand, a comparable differentiation potential of iMSCs and JPCs. Additionally, iMSCs showed significantly longer telomere lengths compared to JPCs indicating rejuvenation of the cells during reprogramming. On the other hand, proliferation, mitochondrial activity, and senescence-associated beta-galactosidase (SA-β-gal) activity indicated early senescence of iMSCs. These data demonstrate the requirement of further optimization strategies to improve mesenchymal development of JPC-derived iPSCs in order to take advantage of the best features of reprogrammed and rejuvenated cells.

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