scholarly journals Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

Science ◽  
2020 ◽  
Vol 367 (6483) ◽  
pp. 1260-1263 ◽  
Author(s):  
Daniel Wrapp ◽  
Nianshuang Wang ◽  
Kizzmekia S. Corbett ◽  
Jory A. Goldsmith ◽  
Ching-Lin Hsieh ◽  
...  
Keyword(s):  
Public Health ◽  
Rapid Development ◽  
Cross Reactivity ◽  
Health Crisis ◽  
Angiotensin Converting Enzyme 2 ◽  
Public Health Crisis ◽  
Binding Domains ◽  
Cryo Electron Microscopy ◽  
Pandemic Threat ◽  
Novel Coronavirus

The outbreak of a novel coronavirus (2019-nCoV) represents a pandemic threat that has been declared a public health emergency of international concern. The CoV spike (S) glycoprotein is a key target for vaccines, therapeutic antibodies, and diagnostics. To facilitate medical countermeasure development, we determined a 3.5-angstrom-resolution cryo–electron microscopy structure of the 2019-nCoV S trimer in the prefusion conformation. The predominant state of the trimer has one of the three receptor-binding domains (RBDs) rotated up in a receptor-accessible conformation. We also provide biophysical and structural evidence that the 2019-nCoV S protein binds angiotensin-converting enzyme 2 (ACE2) with higher affinity than does severe acute respiratory syndrome (SARS)-CoV S. Additionally, we tested several published SARS-CoV RBD-specific monoclonal antibodies and found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs. The structure of 2019-nCoV S should enable the rapid development and evaluation of medical countermeasures to address the ongoing public health crisis.

scholarly journals Cryo-EM Structure of the 2019-nCoV Spike in the Prefusion Conformation

2020 ◽  
Author(s):  
Daniel Wrapp ◽  
Nianshuang Wang ◽  
Kizzmekia S. Corbett ◽  
Jory A. Goldsmith ◽  
Ching-Lin Hsieh ◽  
...  
Keyword(s):  
Public Health ◽  
Rapid Development ◽  
Cross Reactivity ◽  
Public Health Emergency ◽  
Atomic Resolution ◽  
Health Crisis ◽  
Public Health Crisis ◽  
Binding Domains ◽  
Pandemic Threat ◽  
Resolution Structure

AbstractThe outbreak of a novel betacoronavirus (2019-nCov) represents a pandemic threat that has been declared a public health emergency of international concern. The CoV spike (S) glycoprotein is a key target for urgently needed vaccines, therapeutic antibodies, and diagnostics. To facilitate medical countermeasure (MCM) development we determined a 3.5 Å-resolution cryo-EM structure of the 2019-nCoV S trimer in the prefusion conformation. The predominant state of the trimer has one of the three receptor-binding domains (RBDs) rotated up in a receptor-accessible conformation. We also show biophysical and structural evidence that the 2019-nCoV S binds ACE2 with higher affinity than SARS-CoV S. Additionally we tested several published SARS-CoV RBD-specific monoclonal antibodies and found that they do not have appreciable binding to nCoV-2019 S, suggesting antibody cross-reactivity may be limited between the two virus RBDs. The atomic-resolution structure of 2019-nCoV S should enable rapid development and evaluation of MCMs to address the ongoing public health crisis.

scholarly journals Lessons earned and lessons learned: What should be done next to counter the COVID-19 infodemic?

European View ◽  
2020 ◽  
Vol 19 (2) ◽  
pp. 154-163
Author(s):  
Nad’a Kovalčíková ◽  
Ariane Tabatabai
Keyword(s):  
Public Health ◽  
Lessons Learned ◽  
The Novel ◽  
Health Crisis ◽  
The Public ◽  
Public Health Crisis ◽  
Societal Challenges ◽  
The World ◽  
Information Manipulation ◽  
Novel Coronavirus

As governments and citizens around the world have struggled with the novel coronavirus, the information space has turned into a battleground. Authoritarian countries, including Russia, China and Iran, have spread disinformation on the causes of and responses to the pandemic. The over-abundance of information, also referred to as an ‘infodemic’, including manipulated information, has been both a cause and a result of the exacerbation of the public health crisis. It is further undermining trust in democratic institutions, the independent press, and facts and data, and exacerbating the rising tensions driven by economic, political and societal challenges. This article discusses the challenges democracies have faced and the measures they have adopted to counter information manipulation that impedes public health efforts. It draws seven lessons learned from the information war and offers a set of recommendations on tackling future infodemics related to public health.

scholarly journals Coronavirus Pandemic: a major public health crisis for the developed and developing world

2021 ◽  
Vol 15 (03) ◽  
pp. 366-369
Author(s):  
Rooh Ullah ◽  
Muhammad Suleman Rana ◽  
Mehmood Qadir ◽  
Muhammad Usman ◽  
Niaz Ahmed
Keyword(s):  
Public Health ◽  
Severe Acute Respiratory Syndrome ◽  
Viral Infection ◽  
The Novel ◽  
Global Public Health ◽  
Health Crisis ◽  
Public Health Crisis ◽  
The World ◽  
Novel Coronavirus ◽  
Day By Day

Pandemic of novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections in China is now become global public health crisis. At present 87.64% of the world is infected by this deadly illness. The risk from this epidemic depends on the nature of the virus, including how well it transmits from person to person, and the complications resulting from this current illness. The novel coronavirus has killed thousands of people in China and other countries as well; its rate of mortality is increasing day by day. There is an urgent need to control the virus by developing vaccine or any other antiviral drugs to save the world from this deadly viral infection.

scholarly journals Successful Outcomes of Severe COVID-19 in Patient with Chronic Lymphocytic Leukemia: Diagnostic Challenges in Immunocompromised Hosts

2020 ◽  
Vol 12 (1) ◽  
pp. e2020044
Author(s):  
Alexandre Malek
Keyword(s):  
Public Health ◽  
Chronic Lymphocytic Leukemia ◽  
Clinical Presentation ◽  
Severe Case ◽  
Lymphocytic Leukemia ◽  
Health Crisis ◽  
Public Health Crisis ◽  
Current Outbreak ◽  
Novel Coronavirus ◽  
Immunocompromised Hosts

The emergence and spread of 2019 novel coronavirus has led to an unprecedented public health crisis around the globe and has threatened the life of millions of people. We report a severe case of COVID-19 in a patient with chronic lymphocytic leukemia and describe primarily the clinical presentation and the challenges encountered in the COVID-19 diagnosis, treatment and specimens sampling pitfalls. This case highlights the importance of a comprehensive diagnostic approach of pneumonia in immunocompromised hosts, including timely and safe bronchoscopy, because the broad differential diagnosis, more challenging with the current outbreak of COVID-19.

scholarly journals SARS COV 2: Complete Review on Global Pandemic (Covid 19)

2020 ◽  
pp. 62-69
Author(s):  
Praveen Kumar Gupta ◽  
B. S. Rithu ◽  
Kauser Banu ◽  
A. Shruthi ◽  
C. Sahana
Keyword(s):  
Public Health ◽  
The Novel ◽  
Health Crisis ◽  
Public Health Crisis ◽  
Corona Virus ◽  
Global Pandemic ◽  
First Case ◽  
Life Threatening ◽  
Novel Coronavirus ◽  
Threatening Situation

SARS COV 2 (severe acute respiratory syndrome corona virus 2) has created a global health emergency worldwide due to public health crisis and life-threatening situation. According to a recent study it has been reported that the virus was found originated in animal and transmitted to humans through a food chain. First case was reported in Wuhan-china on December 2019, In this review we have enlightened on different aspects of novel coronavirus 2019 and measure to combat the battle against the novel corona virus 2019.

Molecular characterization of SARS-CoV-2

2020 ◽  
Vol 20 ◽  
Author(s):  
Miribane Dërmaku-Sopjani ◽  
Mentor Sopjani
Keyword(s):  
Public Health ◽  
Drug Targets ◽  
Virus Genome ◽  
Health Crisis ◽  
Public Health Crisis ◽  
Therapeutic Drugs ◽  
New Public Health ◽  
New Public ◽  
And Function

Abstract:: The coronavirus disease 2019 (COVID-19) is currently a new public health crisis threatening the world. This pandemic disease is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus has been reported to be originated in bats and by yet unknown intermediary animals were transmitted to humans in China 2019. The SARSCoV- 2 spreads faster than its two ancestors the SARS-CoV and Middle East respiratory syndrome coronavirus (MERSCoV) but has reduced fatality. At present, the SARS-CoV-2 has caused about a 1.16 million of deaths with more than 43.4 million confirmed cases worldwide, resulting in a serious threat to public health globally with yet uncertain impact. The disease is transmitted by inhalation or direct contact with an infected person. The incubation period ranges from 1 to 14 days. COVID-19 is accompanied by various symptoms, including cough, fatigue. In most people the disease is mild, but in some other people, such as in elderly and people with chronic diseases, it may progress from pneumonia to a multi-organ dysfunction. Many people are reported asymptomatic. The virus genome is sequenced, but new variants are reported. Numerous biochemical aspects of its structure and function are revealed. To date, no clinically approved vaccines and/or specific therapeutic drugs are available to prevent or treat the COVID-19. However, there are reported intensive researches on the SARSCoV- 2 to potentially identify vaccines and/or drug targets, which may help to overcome the disease. In this review, we discuss recent advances in understanding the molecular structure of SARS-CoV-2 and its biochemical characteristics.

Anticipating on a post covid-19 world and the pivotal role of science and technology

Coronaviruses ◽  
2020 ◽  
Vol 01 ◽  
Author(s):  
Saeed Khan ◽  
Tusha Sharma ◽  
Basu Dev Banerjee ◽  
Scotty Branch ◽  
Shea Harrelson
Keyword(s):  
Public Health ◽  
Pivotal Role ◽  
Public Healthcare ◽  
Healthcare Organizations ◽  
Health Crisis ◽  
Outbreak Management ◽  
The Public ◽  
Public Health Crisis ◽  
Future Outbreak

: Currently, Coronavirus disease 2019 (COVID-19) has transformed into a severe public health crisis and wreaking havoc worldwide. The ongoing pandemic has exposed the public healthcare system's weaknesses and highlighted the urgent need for investments in scientific programs and policies. A comprehensive program utilizing the science and technologydriven strategies combined with well-resourced healthcare organizations appears to be essential for current and future outbreak management.

Communications and Politics

2018 ◽  
Author(s):  
Joshua M. Sharfstein
Keyword(s):  
Public Health ◽  
Disease Control ◽  
Accurate Information ◽  
Political Judgment ◽  
Political Leaders ◽  
Health Crisis ◽  
Public Health Crisis ◽  
Control And Prevention ◽  
Public Health Officials ◽  
Centers For Disease Control

An effective communications approach starts with a basic dictum set forth by the Centers for Disease Control and Prevention: “Be first, be right, be credible.” Agencies must establish themselves as vital sources of accurate information to maintain the public’s trust. At the same time, public health officials must recognize that communications play out in the context of ideological debates, electoral rivalries, and other political considerations. During a public health crisis, this means that health officials often need to constructively engage political leaders in communications and management. Navigating these waters in the middle of a crisis can be treacherous. Figuring out the best way to engage elected leaders is a core aspect of political judgment.

The Public Health Crisis Survival Guide

2018 ◽  
Author(s):  
Joshua M. Sharfstein
Keyword(s):  
Public Health ◽  
Police Officers ◽  
Health Agency ◽  
Health Improvement ◽  
Strong Response ◽  
Popular Imagination ◽  
Health Crisis ◽  
The Public ◽  
Public Health Crisis ◽  
Critical Skills

Firefighters fight fires. Police officers race to crime scenes, sirens blaring. And health officials? Health officials respond to crises. There are infectious disease crises, budget crises, environmental health crises, human resources crises—and many more. At such critical moments, what happens next really matters. A strong response can generate greater credibility and authority for a health agency and its leadership, while a bungled response can lead to humiliation and even resignation. Health officials must be able to manage and communicate effectively as emotions run high, communities become engaged, politicians lean in, and journalists circle. In popular imagination, leaders intuitively rise to the challenge of a crisis: Either they have what it takes or they do not. In fact, preparation is invaluable, and critical skills can be learned and practiced. Students and health officials alike can prepare not only to avoid catastrophe during crises, but to take advantage of new opportunities for health improvement. The Public Health Crisis Survival Guide provides historical perspective, managerial insight, and strategic guidance to help health officials at all levels not just survive but thrive in the most challenging of times.

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