In Vivo Efficacy of WCK 5222 (Cefepime-Zidebactam) against Multidrug-Resistant Pseudomonas aeruginosa in the Neutropenic Murine Thigh Infection Model
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ABSTRACT We describe the in vivo efficacy of human-simulated WCK 5222 (cefepime-zidebactam) exposure against multidrug-resistant Pseudomonas aeruginosa (meropenem MICs 8 to >256 μg/ml) in a neutropenic murine thigh infection model. WCK 5222 MICs ranged from 4 to 32 μg/ml. Substantial in vivo WCK 5222 activity was observed against all isolates, further enhancing the efficacy of zidebactam alone in 11/16 isolates (WCK 5222 mean reduction, –1.62 ± 0.58 log10 CFU/thigh), and a lack of activity was observed with cefepime monotherapy.
2018 ◽
Vol 63
(2)
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pp. e01040-18
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2014 ◽
Vol 20
(5)
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pp. 312-316
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2014 ◽
Vol 63
(7)
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pp. 945-955
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