scholarly journals Macrolide-Resistant Mycoplasma pneumoniae Pneumonia in Adolescents and Adults: Clinical Findings, Drug Susceptibility, and Therapeutic Efficacy

2013 ◽  
Vol 57 (10) ◽  
pp. 5181-5185 ◽  
Author(s):  
Naoyuki Miyashita ◽  
Hiroto Akaike ◽  
Hideto Teranishi ◽  
Kazunobu Ouchi ◽  
Niro Okimoto
Keyword(s):  
Mycoplasma Pneumoniae ◽  
Therapeutic Efficacy ◽  
Clinical Presentation ◽  
Drug Susceptibility ◽  
Clinical Findings ◽  
Content Type ◽  
Adolescents And Adults ◽  
Mycoplasma Pneumoniae Pneumonia

ABSTRACTWe investigated differences in the clinical findings between 30 patients with macrolide-resistantMycoplasma pneumoniaepneumonia and 43 patients with macrolide-sensitiveM. pneumoniaepneumonia in adolescents and adults. No differences in clinical presentation were observed between the two groups. Among patients with macrolide-resistantMycoplasma pneumoniaepneumonia, treatment was more effective in the groups that received quinolones and minocycline than in the group that received macrolides (P= 0.0361 andP= 0.0237, respectively).

scholarly journals Chlamydia pneumoniae and Mycoplasma pneumoniae pneumonia: comparison of clinical, epidemiological characteristics and laboratory profiles

2005 ◽  
Vol 134 (3) ◽  
pp. 548-555 ◽  
Author(s):  
I. PULJIZ ◽  
I. KUZMAN ◽  
O. DAKOVIC-RODE ◽  
N. SCHÖNWALD ◽  
B. MISE
Keyword(s):  
Pleural Effusion ◽  
Mycoplasma Pneumoniae ◽  
Aspartate Aminotransferase ◽  
Chlamydia Pneumoniae ◽  
Clinical Findings ◽  
Community Acquired Pneumonia ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Epidemiological Characteristics ◽  
Mycoplasma Pneumoniae Pneumonia

The purpose of our retrospective 3-year study was to analyse and compare clinical and epidemiological characteristics in hospitalized patients older than 6 years with community-acquired pneumonia (CAP) caused by Chlamydia pneumoniae (87 patients) and Mycoplasma pneumoniae (147 patients). C. pneumoniae and M. pneumoniae infection was confirmed by serology. C. pneumoniae patients were older (42·12 vs. 24·64 years), and were less likely to have a cough, rhinitis, and hoarseness (P<0·001). C. pneumoniae patients had higher levels of C-reactive protein (CRP), and aspartate aminotransferase (AST) than M. pneumoniae patients (P<0·001). Pleural effusion was recorded more frequently in patients with M. pneumoniae (8·84 vs. 3·37%). There were no characteristic epidemiological and clinical findings that would distinguish CAP caused by M. pneumoniae from C. pneumoniae. However, some factors are indicative for C. pneumoniae such as older age, lack of cough, rhinitis, hoarseness, and higher value of CRP, and AST.

scholarly journals Therapeutic Efficacy of Macrolides, Minocycline, and Tosufloxacin against Macrolide-Resistant Mycoplasma pneumoniae Pneumonia in Pediatric Patients

2013 ◽  
Vol 57 (5) ◽  
pp. 2252-2258 ◽  
Author(s):  
Yasuhiro Kawai ◽  
Naoyuki Miyashita ◽  
Mika Kubo ◽  
Hiroto Akaike ◽  
Atsushi Kato ◽  
...  
Keyword(s):  
Antibiotic Therapy ◽  
Mycoplasma Pneumoniae ◽  
Pediatric Patients ◽  
Definitive Treatment ◽  
23S Rrna ◽  
Content Type ◽  
The Past ◽  
First Choice ◽  
Domain V ◽  
Mycoplasma Pneumoniae Pneumonia

ABSTRACTThe importance of macrolide-resistant (MR)Mycoplasma pneumoniaehas become much more apparent in the past decade. We investigated differences in the therapeutic efficacies of macrolides, minocycline, and tosufloxacin against MRM. pneumoniae. A total of 188 children withM. pneumoniaepneumonia confirmed by culture and PCR were analyzed. Of these, 150 patients had a strain with an MR gene and 134 had one with an A-to-G mutation at position 2063 ofM. pneumoniae23S rRNA domain V. Azithromycin (n= 27), clarithromycin (n= 23), tosufloxacin (n= 62), or minocycline (n= 38) was used for definitive treatment of patients with MRM. pneumoniae. Defervescence within 48 h after the initiation of antibiotic therapy was observed in 41% of the patients in the azithromycin group, 48% of those in the clarithromycin group, 69% of those in the tosufloxacin group, and 87% of those in the minocycline group. The average number of days of fever after the administration of antibiotic treatment was lower in the minocycline and tosufloxacin groups than in the macrolide groups. The decrease in theM. pneumoniaeburden, as estimated by the number of DNA copies, after 48 to 96 h of treatment was more rapid in patients receiving minocycline (P= 0.016) than in those receiving tosufloxacin (P= 0.049), azithromycin (P= 0.273), or clarithromycin (P= 0.107). We found that the clinical and bacteriological efficacies of macrolides against MRM. pneumoniaepneumonia was low. Our results indicated that minocycline rather than tosufloxacin can be considered the first-choice drug for the treatment ofM. pneumoniaepneumonia in children aged ≥8 years.

Clinical Findings of Mycoplasma pneumoniae pneumonia under 3 Year-Old Children

1999 ◽  
Vol 6 (1) ◽  
pp. 78 ◽  
Author(s):  
Sung Soo Lee ◽  
Kyung Lim Youn ◽  
Hyeon Ho Kang ◽  
Byoung Soo Cho ◽  
Sung Ho Cha
Keyword(s):  
Mycoplasma Pneumoniae ◽  
Clinical Findings ◽  
Mycoplasma Pneumoniae Pneumonia

scholarly journals Clinical features of severe Mycoplasma pneumoniae pneumonia in adults admitted to an intensive care unit

2007 ◽  
Vol 56 (12) ◽  
pp. 1625-1629 ◽  
Author(s):  
Naoyuki Miyashita ◽  
Yasushi Obase ◽  
Kazunobu Ouchi ◽  
Kozo Kawasaki ◽  
Yasuhiro Kawai ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Respiratory Failure ◽  
Clinical Features ◽  
Mycoplasma Pneumoniae ◽  
Severe Pneumonia ◽  
Clinical Findings ◽  
Community Acquired Pneumonia ◽  
Life Threatening ◽  
Mycoplasma Pneumoniae Pneumonia

Community-acquired pneumonia (CAP) due to Mycoplasma pneumoniae is usually mild, but some cases develop a severe life-threatening pneumonia. To investigate the clinical features of severe M. pneumoniae pneumonia in adults admitted to an intensive care unit, a multi-centre CAP surveillance study was performed. Among all hospitalized CAP cases between January 2000 and December 2004, there were 227 cases with M. pneumoniae pneumonia without the complication of other pathogens. A total of 13 of the cases required admission to an intensive care unit because of acute respiratory failure (ARF), and the remaining 214 cases (non-ARF) were low to moderately severe. The clinical features of ARF cases were compared with those of non-ARF cases. The underlying conditions in both types of case were identical, whereas clinical findings on admission clearly differed between the two groups. A regimen of an antibiotic effective against M. pneumoniae was begun on average at 9.3 days after the onset of symptoms in ARF cases, which was significantly later than for non-ARF cases (P<0.0001). However, two of the ARF cases progressed to respiratory failure despite the fact that adequate antibiotics were initially administered within 3 days after the onset of symptoms. All ARF cases received corticosteroids with adequate antibiotics, and their condition improved promptly. These results indicate that the clinical features, excluding underlying conditions, clearly differed between severe M. pneumoniae pneumonia and low to moderately severe pneumonia. The delayed administration of adequate antibiotics may contribute to the severity of M. pneumoniae pneumonia. Early corticosteroid therapy with adequate antibiotics should be considered.

Setting a standard for the initiation of steroid therapy in refractory or severe Mycoplasma pneumoniae pneumonia in adolescents and adults

2015 ◽  
Vol 21 (3) ◽  
pp. 153-160 ◽  
Author(s):  
Naoyuki Miyashita ◽  
Yasuhiro Kawai ◽  
Norikazu Inamura ◽  
Takaaki Tanaka ◽  
Hiroto Akaike ◽  
...  
Keyword(s):  
Mycoplasma Pneumoniae ◽  
Steroid Therapy ◽  
Adolescents And Adults ◽  
Mycoplasma Pneumoniae Pneumonia

Computer-Aided Diagnosis in Jaundice: Comparison of Knowledge-based and Probabilistic Approaches

1996 ◽  
Vol 35 (01) ◽  
pp. 41-51 ◽  
Author(s):  
F. Molino ◽  
D. Furia ◽  
F. Bar ◽  
S. Battista ◽  
N. Cappello ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Clinical Information ◽  
Diagnostic Value ◽  
Clinical Findings ◽  
Clinical Documentation ◽  
Data Set ◽  
Knowledge Based ◽  
Number Of Patients ◽  
Support Tools ◽  
Aided Diagnosis

AbstractThe study reported in this paper is aimed at evaluating the effectiveness of a knowledge-based expert system (ICTERUS) in diagnosing jaundiced patients, compared with a statistical system based on probabilistic concepts (TRIAL). The performances of both systems have been evaluated using the same set of data in the same number of patients. Both systems are spin-off products of the European project Euricterus, an EC-COMACBME Project designed to document the occurrence and diagnostic value of clinical findings in the clinical presentation of jaundice in Europe, and have been developed as decision-making tools for the identification of the cause of jaundice based only on clinical information and routine investigations. Two groups of jaundiced patients were studied, including 500 (retrospective sample) and 100 (prospective sample) subjects, respectively. All patients were independently submitted to both decision-support tools. The input of both systems was the data set agreed within the Euricterus Project. The performances of both systems were evaluated with respect to the reference diagnoses provided by experts on the basis of the full clinical documentation. Results indicate that both systems are clinically reliable, although the diagnostic prediction provided by the knowledge-based approach is slightly better.

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