Therapeutic efficacy of azithromycin, clarithromycin, minocycline and tosufloxacin against macrolide-resistant and macrolide-sensitive Mycoplasma pneumoniae pneumonia in pediatric patients

Mycoplasma pneumoniae is a common atypical respiratory pathogen causing community-acquired pneumonia in children. Co-infection with other respiratory viruses is common in pediatric patients but super-infection with bacteria other than Streptococcus pneumoniae and Haemophilus influenzae is rare. The first case of Chromobacterium violaceum infection incubated during and manifested after pneumonia caused by Mycoplasma pneumoniae in a 12-month old girl without any known history of immunodeficiency is here reported. The patient developed fever with redness and swelling over the middle phalanx of the right hand index finger which progressed to the formation of skin abscess. Following a course of intravenous meropenem and surgical drainage of the skin abscess, the patient fully recovered and was discharged.

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Prediction Model for Severe Mycoplasma Pneumoniae Pneumonia in Pediatric Patients by Admission Laboratory Indicators

10.21203/rs.3.rs-403591/v1 ◽

2021 ◽

Author(s):

Qing Chang ◽

Hong-Lin Chen ◽

Neng-Shun Wu ◽

Yan-Min Gao ◽

Rong Yu ◽

...

Keyword(s):

Prediction Model ◽

Mycoplasma Pneumoniae ◽

Eosinophil Count ◽

Goodness Of Fit ◽

Pediatric Patients ◽

Community Acquired Pneumonia ◽

Goodness Of Fit Test ◽

Independent Risk Factors ◽

Mycoplasma Pneumoniae Pneumonia ◽

Actual Incidence

Abstract Objective The purpose of this study was to develop a model for predicting severe mycoplasma pneumoniae pneumonia (SMMP) in pediatric patients with MMP on admission by laboratory indicators. Methods Pediatric patients with MPP from January 2019 to December 2020 in our hospital were enrolled in this study. SMMP was diagnosed according to guideline for diagnosis and treatment of community acquired pneumonia in children (2019 version). Prediction model was developed according to the admission laboratory indicators. ROC curve and Goodness of fit test were analyzed for the predictive value. Results A total of 233 MMP patients were included in the study, with 121 males and 112 females, aged 4.541 (1–14) years. Among them, 84 (36.1%, 95% CI 29.9%-42.6%) pediatric patients were diagnosed as SMPP. Some admission laboratory indicators (IgM, eosinophil proportion, eosinophil count, hemoglobin, ESR, total protein, albumin and prealbumin) were found statistically different (P < 0.05) between non-SMMP group and SMMP group. Logistic regress analysis showed IgM, eosinophil proportion, eosinophil count, ESR, and prealbumin were independent risk factors for SMMP. According to these five admission laboratory indicators, Nomograph prediction model was developed. The AUC of the Nomograph prediction model was 0.777, and the goodness of fit test showed that the predicted incidence of the model was consistent with the actual incidence (χ2 = 244.51, P = 0.203). Conclusion We developed a model for predicting SMMP in pediatric patients by admission laboratory indicators. This model has good discrimination and calibration, which provides a basis for the early identification SMMP on admission.

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Plasma soluble B7-H3 levels for severity evaluation in pediatric patients with Mycoplasma pneumoniae pneumonia

International Immunopharmacology ◽

10.1016/j.intimp.2019.05.014 ◽

2019 ◽

Vol 73 ◽

pp. 163-171

Author(s):

Yunyun Xu ◽

Lexiang Yu ◽

Chuangli Hao ◽

Yuqing Wang ◽

Canhong Zhu ◽

...

Keyword(s):

Mycoplasma Pneumoniae ◽

Pediatric Patients ◽

Mycoplasma Pneumoniae Pneumonia

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1459. The Scope of Mycoplasma Pneumoniae Pneumonia Diagnosed by Multiplex Polymerase Chain Reaction Respiratory Viral Panel in Pediatric Patients in Hawaii

Open Forum Infectious Diseases ◽

10.1093/ofid/ofy210.1289 ◽

2018 ◽

Vol 5 (suppl_1) ◽

pp. S451-S451

Author(s):

Mark Porter ◽

Natascha Ching

Keyword(s):

Polymerase Chain Reaction ◽

Mycoplasma Pneumoniae ◽

Multiplex Polymerase Chain Reaction ◽

Pediatric Patients ◽

Chain Reaction ◽

Polymerase Chain ◽

Mycoplasma Pneumoniae Pneumonia

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Therapeutic Efficacy of Macrolides, Minocycline, and Tosufloxacin against Macrolide-Resistant Mycoplasma pneumoniae Pneumonia in Pediatric Patients

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.00048-13 ◽

2013 ◽

Vol 57 (5) ◽

pp. 2252-2258 ◽

Cited By ~ 50

Author(s):

Yasuhiro Kawai ◽

Naoyuki Miyashita ◽

Mika Kubo ◽

Hiroto Akaike ◽

Atsushi Kato ◽

...

Keyword(s):

Antibiotic Therapy ◽

Mycoplasma Pneumoniae ◽

Pediatric Patients ◽

Definitive Treatment ◽

23S Rrna ◽

Content Type ◽

The Past ◽

First Choice ◽

Domain V ◽

Mycoplasma Pneumoniae Pneumonia

ABSTRACTThe importance of macrolide-resistant (MR)Mycoplasma pneumoniaehas become much more apparent in the past decade. We investigated differences in the therapeutic efficacies of macrolides, minocycline, and tosufloxacin against MRM. pneumoniae. A total of 188 children withM. pneumoniaepneumonia confirmed by culture and PCR were analyzed. Of these, 150 patients had a strain with an MR gene and 134 had one with an A-to-G mutation at position 2063 ofM. pneumoniae23S rRNA domain V. Azithromycin (n= 27), clarithromycin (n= 23), tosufloxacin (n= 62), or minocycline (n= 38) was used for definitive treatment of patients with MRM. pneumoniae. Defervescence within 48 h after the initiation of antibiotic therapy was observed in 41% of the patients in the azithromycin group, 48% of those in the clarithromycin group, 69% of those in the tosufloxacin group, and 87% of those in the minocycline group. The average number of days of fever after the administration of antibiotic treatment was lower in the minocycline and tosufloxacin groups than in the macrolide groups. The decrease in theM. pneumoniaeburden, as estimated by the number of DNA copies, after 48 to 96 h of treatment was more rapid in patients receiving minocycline (P= 0.016) than in those receiving tosufloxacin (P= 0.049), azithromycin (P= 0.273), or clarithromycin (P= 0.107). We found that the clinical and bacteriological efficacies of macrolides against MRM. pneumoniaepneumonia was low. Our results indicated that minocycline rather than tosufloxacin can be considered the first-choice drug for the treatment ofM. pneumoniaepneumonia in children aged ≥8 years.

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Risk factors of 90-day rehospitalization following discharge of pediatric patients hospitalized with mycoplasma Pneumoniae pneumonia

BMC Infectious Diseases ◽

10.1186/s12879-019-4616-9 ◽

2019 ◽

Vol 19 (1) ◽

Author(s):

Le Wang ◽

Zhishan Feng ◽

Jinfeng Shuai ◽

Jianhua Liu ◽

Guixia Li

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Body Temperature ◽

Mycoplasma Pneumoniae ◽

Influenza A ◽

Pediatric Patients ◽

Clinical Laboratory ◽

Multiple Logistic Regression Analysis ◽

Multiple Logistic Regression ◽

Mycoplasma Pneumoniae Pneumonia

Abstract Background Among pediatric patients hospitalized for Mycoplasma pneumoniae pneumonia (MPP), the risk factors for 90-day readmission after discharge is undefined. Methods We conducted a retrospective observational study of patients <14 years of age who were discharged with a diagnosis of MPP between January 2016 and February 2017. We collected clinical, laboratory and radiographic variables at the time of initial admission. We assessed pneumonia-related readmission within 90-day after discharge. Risk factors independently associated with rehospitalization were identified using multiple logistic regression models. Results Of the 424 MPP hospitalizations, 48 (11.3%) were readmitted within 90 days and were mainly diagnosed with pneumonia. Patients with younger age or coinfection with influenza A were more likely to be readmitted. In addition, compared with children without readmission, the readmission ones showed different clinical and laboratory characteristics at the index hospital admission. Multiple logistic regression analysis identified age (OR 0.815, 95%CI 0.706–0.940) and body temperature (OR 0.659, 95%CI 0.518–0.839) were significantly associated with lower risk of 90-day readmission. Coinfection with influenza was independently associated with a greater likelihood of 90-day readmission (OR 4.746, 95%CI 1.191–18.913). Conclusions Readmission after MPP are common and is related to patients’ age, body temperature and influenza A coinfection during initial hospital stay, indicating potential targets could be noticed to reduce the rehospitalization after pediatric MPP.

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