DaptomycinIn VitroActivity against Methicillin-Resistant Staphylococcus aureus Is Enhanced by d-Cycloserine in a Mechanism Associated with a Decrease in Cell Surface Charge
2013 ◽
Vol 57
(9)
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pp. 4537-4539
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Keyword(s):
ABSTRACTThe killing activity of daptomycin against an isogenic pair of daptomycin-susceptible and daptomycin-nonsusceptible (DNS) methicillin-resistantStaphylococcus aureus(MRSA) strains was enhanced by the addition of certain cell wall agents at 1× MIC. However, when high inocula of the DNS strain were used, no significant killing was observed in our experiments. Cytochromecbinding assays revealedd-cycloserine as the only agent associated with a reduction in the cell surface charge for both strains at the concentrations used.
2011 ◽
Vol 55
(6)
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pp. 3046-3050
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2015 ◽
Vol 59
(10)
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pp. 6223-6232
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