An A643V Amino Acid Substitution in Upc2p Contributes to Azole Resistance in Well-Characterized Clinical Isolates ofCandida albicans
2010 ◽
Vol 55
(2)
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pp. 940-942
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Keyword(s):
ABSTRACTTheCandida albicansUpc2p transcription factor regulatesERG11, encoding the target of azole drugs. Gain-of-function mutations that contribute to resistance were recently identified in a series of sequential clinical isolates (N. Dunkel, T. T. Liu, K. S. Barker, R. Homayouni, J. Morschhauser, and P. D. Rogers, Eukaryot. Cell 7:1180-1190, 2008). In the present study,UPC2was sequenced from a matched set of 17 isolates. An A643V substitution was present in all of the isolates in the series that overexpressedERG11. Azole susceptibility, ergosterol levels, and expression ofERGgenes were elevated in the A643V clinical isolates and in reconstructed strains.
2014 ◽
Vol 59
(1)
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pp. 450-460
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2013 ◽
Vol 42
(5)
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pp. 410-415
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1999 ◽
Vol 43
(11)
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pp. 2671-2677
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2000 ◽
Vol 44
(11)
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pp. 2985-2990
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Keyword(s):
2015 ◽
Vol 59
(10)
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pp. 6615-6619
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2003 ◽
Vol 47
(4)
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pp. 1220-1227
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