Susceptibility Testing of Antibiotics That Degrade Faster than the Doubling Time of Slow-Growing Mycobacteria: Ertapenem Sterilizing Effect versus Mycobacterium tuberculosis
2016 ◽
Vol 60
(5)
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pp. 3193-3195
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Keyword(s):
ABSTRACTDrug susceptibility tests (DSTs) forMycobacterium tuberculosisrequire at least 7 days of incubation. Drugs that are unstable at 37°C, such as ertapenem, are likely to be degraded before killing or inhibiting slow-growing bacteria. This would alter the MICs of these drugs, including ertapenem, leading to falsely high MICs. Here, we describe a new strategy we developed to perform DSTs and measure MICs for such unstable compounds.
2014 ◽
Vol 59
(3)
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pp. 1542-1548
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2016 ◽
Vol 54
(12)
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pp. 3022-3027
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1987 ◽
Vol 33
(12)
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pp. 1064-1068
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2013 ◽
Vol 57
(6)
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pp. 2522-2525
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2014 ◽
Vol 2
(03)
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pp. 80-83
Pyrazinamide Is Active against Mycobacterium tuberculosis Cultures at Neutral pH and Low Temperature
2016 ◽
Vol 60
(8)
◽
pp. 4956-4960
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2018 ◽
Vol 63
(2)
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pp. e01798-18
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2013 ◽
Vol 58
(1)
◽
pp. 11-18
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2011 ◽
Vol 55
(5)
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pp. 2032-2041
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