Effects of Small-Particle Aerosols of Rimantadine and Ribavirin on Arterial Blood pH and Gas Tensions and Lung Water Content of A2 Influenza-Infected Mice

We studied the effects of systemic venous hypertension (SVH) of 25 cmH2O, with and without fluid overload (100 ml.kg-1.h-1 x 4 h), on the lung water content and pulmonary function of anesthetized dogs. SVH was produced by inflating a balloon in the right atrium. Pulmonary extravascular water (PEW) was measured by gravimetric techniques taking the water content of trapped blood into consideration. Subdivisions of lung volume, pulmonary resistance, dynamic compliance, and the single-breath nitrogen washout curve were performed in a body plethysmograph. Vascular pressures, serum oncotic pressure, and arterial blood gases were also measured. Systemic venous hypertension alone produced no change in lung water content (control PEW = 3.46 +/- 0.16; SVH PEW = 3.44 +/- 0.18 g H2O/g dry tissue, mean +/- SD) or alterations in pulmonary function. Fluid overload alone produced an insignificant increase in PEW (4.24 +/- 0.72 g H2O/g dry tissue) and decreases in vital capacity and functional residual capacity. SVH in combination with fluid overload resulted in a significant increase in lung water (4.78 +/- 1.03 g H2O/g dry tissue) and decreases in functional residual capacity, vital capacity, dynamic compliance, and arterial blood oxygen tension as well as increased pulmonary resistance. We conclude that SVH favors the formation of pulmonary edema under conditions of increased pulmonary transcapillary fluid exchange and may particularly augment airway edema.

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Magnetic Resonance Imaging Spatial and Time Study of Lung Water Content in Newborn Lamb: Methods and Preliminary Results

Investigative Radiology ◽

10.1097/rli.0b013e31816900bb ◽

2008 ◽

Vol 43 (6) ◽

pp. 470-480 ◽

Cited By ~ 8

Author(s):

Romain Viard ◽

Pierre Tourneux ◽

Laurent Storme ◽

Julie-Marie Girard ◽

Nacim Betrouni ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Water Content ◽

Time Study ◽

Resonance Imaging ◽

Lung Water ◽

Newborn Lamb ◽

Preliminary Results ◽

Lung Water Content

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Bedside cardiopulmonary ultrasonography evaluates lung water content in very low-weight preterm neonates with patent ductus arteriosus

World Journal of Clinical Cases ◽

10.12998/wjcc.v9.i8.1827 ◽

2021 ◽

Vol 9 (8) ◽

pp. 1827-1834

Author(s):

Li-Fang Yu ◽

Chen-Ke Xu ◽

Min Zhao ◽

Lin Niu ◽

Xian-Mei Huang ◽

...

Keyword(s):

Patent Ductus Arteriosus ◽

Water Content ◽

Ductus Arteriosus ◽

Preterm Neonates ◽

Lung Water ◽

Low Weight ◽

Lung Water Content ◽

Patent Ductus

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Maternal haemodynamics and lung water content during percutaneous fetoscopic interventions under general anaesthesia

British Journal of Anaesthesia ◽

10.1093/bja/aep016 ◽

2009 ◽

Vol 102 (4) ◽

pp. 523-527 ◽

Cited By ~ 12

Author(s):

R. Hering ◽

A. Hoeft ◽

C. Putensen ◽

K. Tchatcheva ◽

R. Stressig ◽

...

Keyword(s):

Water Content ◽

General Anaesthesia ◽

Lung Water ◽

Lung Water Content

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Propofol Activation of the Nrf2 Pathway Is Associated with Amelioration of Acute Lung Injury in a Rat Liver Transplantation Model

Oxidative Medicine and Cellular Longevity ◽

10.1155/2014/258567 ◽

2014 ◽

Vol 2014 ◽

pp. 1-9 ◽

Cited By ~ 34

Author(s):

Weifeng Yao ◽

Gangjian Luo ◽

Guosong Zhu ◽

Xinjin Chi ◽

Ailan Zhang ◽

...

Keyword(s):

Liver Transplantation ◽

Acute Lung Injury ◽

Lung Injury ◽

Water Content ◽

High Dose ◽

Lung Pathology ◽

Lung Water ◽

Sod Activity ◽

Nrf2 Pathway ◽

Lung Water Content

Objective. This study aimed to investigate whether propofol pretreatment can protect against liver transplantation-induced acute lung injury (ALI) and to explore whether Nrf2 pathway is involved in the protections provided by propofol pretreatment.Method. Adult male Sprague-Dawley rats were divided into five groups based on the random number table. Lung pathology was observed by optical microscopy. Lung water content was assessed by wet/dry ratio, and PaO2was detected by blood gas analysis. The contents of H2O2, MDA, and SOD activity were determined by ELISA method, and the expression of HO-1, NQO1, Keap1, and nuclear Nrf2 was assayed by western blotting.Results. Compared with saline-treated model group, both propofol and N-acetylcysteine pretreatment can reduce the acute lung injury caused by orthotopic autologous liver transplantation (OALT), decrease the lung injury scores, lung water content, and H2O2and MDA levels, and improve the arterial PaO2and SOD activity. Furthermore, propofol (but not N-acetylcysteine) pretreatment especially in high dose inhibited the expression of Keap1 and induced translocation of Nrf2 into the nucleus to further upregulate the expression of HO-1 and NQO1 downstream.Conclusion. Pretreatment with propofol is associated with attenuation of OALT-induced ALI, and the Nrf2 pathway is involved in the antioxidative processes.

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