Effects of cinnamic acid derivatives on in vitro growth of Plasmodium falciparum and on the permeability of the membrane of malaria-infected erythrocytes.

The role played by cinnamic acid derivatives in treating cancer, bacterial infections, diabetes and neurological disorders, among many, has been reported. Cinnamic acid is obtained from cinnamon bark. Its structure is composed of a benzene ring, an alkene double bond and an acrylic acid functional group making it possible to modify the aforementioned functionalities with a variety of compounds resulting in bioactive agents with enhanced efficacy. The nature of the substituents incorporated into cinnamic acid has been found to play a huge role in either enhancing or decreasing the biological efficacy of the synthesized cinnamic acid derivatives. Some of the derivatives have been reported to be more effective when compared to the standard drugs used to treat chronic or infectious diseases in vitro, thus making them very promising therapeutic agents. Compound 20 displayed potent anti-TB activity, compound 27 exhibited significant antibacterial activity on S. aureus strain of bacteria and compounds with potent antimalarial activity are 35a, 35g, 35i, 36i, and 36b. Furthermore, compounds 43d, 44o, 55g–55p, 59e, 59g displayed potent anticancer activity and compounds 86f–h were active against both hAChE and hBuChE. This review will expound on the recent advances on cinnamic acid derivatives and their biological efficacy.

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Germinated and Ungerminated Seeds Extract from TwoLupinusSpecies: Biological Compounds Characterization and In Vitro and In Vivo Evaluations

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2016/7638542 ◽

2016 ◽

Vol 2016 ◽

pp. 1-8 ◽

Cited By ~ 2

Author(s):

Bogdan Andor ◽

Corina Danciu ◽

Ersilia Alexa ◽

Istvan Zupko ◽

Elena Hogea ◽

...

Keyword(s):

Cinnamic Acid ◽

Therapeutic Potential ◽

Lupinus Albus ◽

Biological Evaluation ◽

Lupinus Angustifolius ◽

Cinnamic Acid Derivatives ◽

Natural Agents ◽

Germinated Seeds

In recent years, nutraceuticals attracted a great amount of attention in the biomedical research due to their significant contribution as natural agents for prevention of various health issues. Ethanolic extracts from the ungerminated and germinated seeds ofLupinus albusL. andLupinus angustifoliusL. were analyzed for the content in isoflavones (genistein) and cinnamic acid derivatives. Additionally, the extracts were evaluated for antimicrobial, antiproliferative, and anti-inflammatory properties, using in vitro and in vivo tests. Germination proved to be a method of choice in increasing the amount of genistein and cinnamic acid derivatives in bothLupinus albusL. andLupinus angustifolius L.seeds. Biological evaluation of all vegetal extracts revealed a weak therapeutic potential for both ungerminated and germinated seeds.

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Antiviral Activity of Cholesteryl Esters of Cinnamic Acid Derivatives

Zeitschrift für Naturforschung C ◽

10.1515/znc-1998-9-1017 ◽

1998 ◽

Vol 53 (9-10) ◽

pp. 883-887 ◽

Cited By ~ 7

Author(s):

Angel S. Galabov ◽

Lubomira Nikolaeva ◽

Daniela Todorova ◽

Tsenka Milkova

Keyword(s):

Antiviral Activity ◽

Cinnamic Acid ◽

Cholesteryl Esters ◽

Cinnamic Acid Derivatives ◽

Steryl Esters ◽

Causative Agents ◽

Marked Activity ◽

Taxonomic Groups

Cholesteryl 3”,4”-dimethoxycinnamate (7) and a new synthesized o-coumaroyl ester of 3β- (2’-hydroxyethoxy)-cholest-5-en (13) exhibited a marked activity against poliovirus type 1 (Mahoney). Compound 7 showed an approximately 20-fold greater selectivity in its antiviral activity than compound 13. These compounds were selected from thirteen steryl esters of cinnamic acid derivatives through an in vitro antiviral screening against viruses belonging to taxonomic groups with causative agents of important human infectious diseases to which chemotherapy is indicated, i.e. Picornaviridae, Orthomyxoviridae, Paramyxoviridae and Herpesviridae.

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The combined effect of iron chelators and classical antimalarials on the in-vitro growth of Plasmodium falciparum

Journal of Antimicrobial Chemotherapy ◽

10.1093/jac/30.3.273 ◽

1992 ◽

Vol 30 (3) ◽

pp. 273-278 ◽

Cited By ~ 12

Author(s):

Robyn L. van Zyl ◽

Ivan Havlik ◽

Felix S.E. Monteagudo

Keyword(s):

Plasmodium Falciparum ◽

Combined Effect ◽

Iron Chelators ◽

In Vitro Growth

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Human-human hybridomas secreting monoclonal antibodies to the Mr 195,000 Plasmodium falciparum blood stage antigen.

Journal of Experimental Medicine ◽

10.1084/jem.163.1.179 ◽

1986 ◽

Vol 163 (1) ◽

pp. 179-188 ◽

Cited By ~ 18

Author(s):

R Schmidt-Ullrich ◽

J Brown ◽

H Whittle ◽

P S Lin

Keyword(s):

Plasmodium Falciparum ◽

Growth Inhibition ◽

Protective Immunity ◽

Lymphoblastoid Cell Line ◽

In Vitro Growth ◽

Human Lymphoblastoid Cell ◽

Immune Precipitation ◽

Human Lymphoblastoid Cell Line ◽

Donor Lymphocytes

Using the human lymphoblastoid cell line, GM 4672, and PBL of Gambian adults immune to Plasmodium falciparum (Pf) malaria, we have produced human-human hybridomas and selected those that produce mAb against Pf antigens. The fusion frequency, using PWM-stimulated donor lymphocytes was between 6.8 X 10(-5) and 1.5 X 10(-6). Using immune fluorescence, immune precipitation, and Pf in vitro growth inhibition, we cloned four hybridomas that reacted with the Pf Mr 195,000 schizont/merozoite protein. The differences in proteins immune precipitated and in growth inhibition indicate that, during development of protective immunity against Pf malaria, a spectrum of antibodies is produced reacting with different epitopes on the same antigen. Only a portion of these antibodies exhibits biological activity, suggesting that the recognition of certain epitopes is required for the development of a protective immune response.

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