scholarly journals Pharmacokinetics and Pharmacodynamics of Gatifloxacin against Streptococcus pneumoniae and Staphylococcus aureus in a Granulocyte-Rich Exudate

2002 ◽  
Vol 46 (11) ◽  
pp. 3630-3633 ◽  
Author(s):  
Andrej Trampuz ◽  
Gerd Laifer ◽  
Markus Wenk ◽  
Zarko Rajacic ◽  
Werner Zimmerli
Keyword(s):  
Staphylococcus Aureus ◽  
Single Dose ◽  
Streptococcus Pneumoniae ◽  
Ex Vivo ◽  
Blister Fluid ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Skin Blister ◽  
And Staphylococcus Aureus

ABSTRACT The pharmacokinetics of gatifloxacin were assessed in serum and in skin blister fluid (SBF), as was the pharmacodynamic activity in SBF. Five hours after a single dose of gatifloxacin, SBF killed 2.5 logs of Streptococcus pneumoniae and 1.5 log of Staphylococcus aureus during a 2-h incubation ex vivo.

scholarly journals Pharmacokinetics and Pharmacodynamics of Levofloxacin against Streptococcus pneumoniae and Staphylococcus aureus in Human Skin Blister Fluid

2000 ◽  
Vol 44 (5) ◽  
pp. 1352-1355 ◽  
Author(s):  
Andrej Trampuz ◽  
Markus Wenk ◽  
Zarko Rajacic ◽  
Werner Zimmerli
Keyword(s):  
Staphylococcus Aureus ◽  
Streptococcus Pneumoniae ◽  
Oral Dose ◽  
Human Skin ◽  
Bactericidal Activity ◽  
Ex Vivo ◽  
Blister Fluid ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Skin Blister ◽  
And Staphylococcus Aureus

ABSTRACT The pharmacokinetics of levofloxacin in serum and in skin blister fluid (SBF) was determined for 20 volunteers after a single 500-mg oral dose of levofloxacin. In addition, ex vivo bactericidal activity of SBF against Streptococcus pneumoniae and Staphylococcus aureus was studied. SBF containing levofloxacin and granulocytes killed 5.2 log of Streptococcus pneumoniae bacteria and 2.0 log of Staphylococcus aureus bacteria during a 6-h incubation.

scholarly journals Epidemiology of Streptococcus pneumoniae and Staphylococcus aureus colonization in healthy Venezuelan children

2010 ◽  
Vol 30 (1) ◽  
pp. 7-19 ◽  
Author(s):  
B. Quintero ◽  
M. Araque ◽  
C. van der Gaast-de Jongh ◽  
F. Escalona ◽  
M. Correa ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Streptococcus Pneumoniae ◽  
And Staphylococcus Aureus

Mucosal Pathology of the Nose and Sinuses: A Study in Experimental Maxillary Sinusitis in Rabbits Induced by Streptococcus Pneumoniae, Bacteroides Fragilis, and Staphylococcus Aureus

1993 ◽  
Vol 7 (3) ◽  
pp. 125-132 ◽  
Author(s):  
Masaya Fukami ◽  
Tomas Norlander ◽  
Pontus Stierna ◽  
Karl Magnus Westrin ◽  
Bengt Carlsöö ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Streptococcus Pneumoniae ◽  
Nasal Mucosa ◽  
Maxillary Sinusitis ◽  
Bacteroides Fragilis ◽  
Sensory Epithelium ◽  
Squamous Cell Metaplasia ◽  
Tissue Factors ◽  
Tissue Reactions ◽  
And Staphylococcus Aureus

Unilateral maxillary sinusitis was experimentally induced in New Zealand White rabbits with Streptococcus pneumoniae serotype 3, Bacteroides fragilis NCTC 9343, and Staphylococcus aureus V8 in order to study possible differences in the inflammatory response of the sinus and nasal mucosa at different time-intervals during a 12-week period of infection. The initial sinus mucosal response, most pronounced in pneumococcal sinusitis, was characterized by leukocytosis, epithelial desquamation, and squamous cell metaplasia. Tissue reactions at later intervals included fibrosis of lamina propria, gland involution, polyp formation, and bone remodelling, and were most pronounced in S. aureus and B. fragilis sinusitis. The nasal mucosa was altered with a redistribution of goblet cells, development of polyps in the ethmoidal region, involution of Bowman's glands and locally, areas of degenerated olfactory sensory epithelium. These findings endorse that the degree of local pathology depends on the infecting microorganism's specific pathogenetic factors. However, local tissue factors guiding the cellular inflammatory proliferative and regenerative processes are also of fundamental importance for the type of pathological changes occurring in an infected nasal or sinus mucosa.

scholarly journals Streptococcus pneumoniae and Staphylococcus aureus carriage in healthy school-age children and adolescents

2015 ◽  
Vol 64 (4) ◽  
pp. 427-431 ◽  
Author(s):  
Susanna Esposito ◽  
Leonardo Terranova ◽  
Luca Ruggiero ◽  
Beatrice Ascolese ◽  
Valentina Montinaro ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Streptococcus Pneumoniae ◽  
Children And Adolescents ◽  
School Age Children ◽  
School Age ◽  
And Staphylococcus Aureus

scholarly journals Salicylate blockade of granulocyte adherence and the inflammatory response to experimental peritonitis

Blood ◽  
1979 ◽  
Vol 53 (5) ◽  
pp. 1018-1022
Author(s):  
PJ Spagnuolo ◽  
JJ Ellner
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Streptococcus Pneumoniae ◽  
Inflammatory Response ◽  
Sodium Salicylate ◽  
Nylon Fiber ◽  
Intraperitoneal Infection ◽  
And Staphylococcus Aureus ◽  
Human And Mouse

Aspirin profoundly inhibited the in vitro augmentation of human and mouse granulocyte adherence to nylon fiber induced by the bacterial products Escherichia coli endotoxin and Staphylococcus aureus culture filtrate. Granulocytes obtained from normal volunteers during the 48 hr following ingestion of aspirin did not respond normally to endotoxin stimulation. Furthermore, pretreatment of mice with sodium salicylate prior to intraperitoneal infection with Streptococcus pneumoniae impaired granulocyte exudation and resulted in uncontrolled bacteremia and greater lethality of infection.

Sign in / Sign up

Export Citation Format

Share Document