Treatment of Murine Fusariosis with SCH 56592
1999 ◽
Vol 43
(3)
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pp. 589-591
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Keyword(s):
ABSTRACT Doses of 10 to 100 mg of the azole antifungal agent SCH 56592/kg of body weight/day were studied in immunocompetent mice as therapy for systemic infection by Fusarium solani. Treatment was begun 1 h after intravenous infection and continued daily for 4 or 13 doses. Prolongation of survival and organ clearance were dependent on both the dose and the duration of SCH 56592 therapy, with the best results seen at 50 and 100 mg/kg/day. The results at the highest doses of SCH 56592 used (50 or 100 mg/kg/day) were comparable to those obtained with amphotericin B at 1 mg/kg/day. SCH 56592 has potential for therapy of systemic infections caused byF. solani.
2002 ◽
Vol 46
(2)
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pp. 367-370
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Keyword(s):
1996 ◽
Vol 40
(2)
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pp. 494-496
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2003 ◽
Vol 47
(6)
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pp. 1948-1951
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Keyword(s):
2010 ◽
Vol 54
(10)
◽
pp. 4074-4077
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Keyword(s):
2006 ◽
Vol 50
(6)
◽
pp. 2240-2243
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Keyword(s):
1999 ◽
Vol 43
(2)
◽
pp. 322-328
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Keyword(s):
2000 ◽
Vol 44
(8)
◽
pp. 2017-2022
◽
1998 ◽
Vol 42
(1)
◽
pp. 147-150
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Keyword(s):
2006 ◽
Vol 51
(1)
◽
pp. 73-77
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Keyword(s):