scholarly journals Protection against Asiatic Taenia solium Induced by a Recombinant 45W-4B Protein

2008 ◽  
Vol 16 (2) ◽  
pp. 230-232 ◽  
Author(s):  
Xuenong Luo ◽  
Yadong Zheng ◽  
Junling Hou ◽  
Shaohua Zhang ◽  
Xuepeng Cai
Keyword(s):  
Human Health ◽  
Taenia Solium ◽  
Parasite Burden ◽  
Animal Trials

ABSTRACT Taenia solium is a great threat not only to human health but also to the pig-raising industry. Oncospheral stage-specific 45W proteins are good candidates for the development of anticysticercosis vaccines. In this study, a recombinant 45W-4B protein was highly produced and used for vaccination. Two animal trials resulted in a significant reduction in parasite burden induced by the definite protein against Asiatic T. solium, up to 97.0% and 98.4%, respectively. These provide informative results for the development of effective 45W-4B vaccines against cysticercosis caused by both Chinese and Mexican T. solium isolates and even by other isolates.

scholarly journals Comparative evaluation of different immunoassays for the detection of Taenia solium cysticercosis in swine with low parasite burden

2007 ◽  
Vol 102 (6) ◽  
pp. 725-731 ◽  
Author(s):  
Andréia Bartachini Gomes ◽  
Killarney Ataíde Soares ◽  
Ednéia Casagrande Bueno ◽  
Noeli Maria Espindola ◽  
Alberto Hiroshi Iha ◽  
...  
Keyword(s):  
Comparative Evaluation ◽  
Taenia Solium ◽  
Parasite Burden

scholarly journals Comparative evaluation of different immunoassays for the detection of Taenia solium cysticercosis in swine with low parasite burden

2007 ◽  
Vol 102 (6) ◽  
Author(s):  
Andréia Bartachini Gomes ◽  
Killarney Ataíde Soares ◽  
Ednéia Casagrande Bueno ◽  
Noeli Maria Espindola ◽  
Alberto Hiroshi Iha ◽  
...  
Keyword(s):  
Comparative Evaluation ◽  
Taenia Solium ◽  
Parasite Burden

Tapeworms, Meat and Man: A Brief Review and Update of Cysticercosis Caused by Taenia Saginata and Taenia Solium

1979 ◽  
Vol 42 (1) ◽  
pp. 58-64 ◽  
Author(s):  
D. W. HIRD ◽  
M. M. PULLEN
Keyword(s):  
United States ◽  
Human Health ◽  
Latin American ◽  
Financial Burden ◽  
Taenia Solium ◽  
Developed Countries ◽  
The United States ◽  
Health Concern ◽  
Special Treatment ◽  
Taenia Saginata

Three species of tapeworms may be transmitted to man by ingestion of animal flesh: Taenia saginata, Taenia solium, and Diphyllobothrium latum. The first two are the subject of this brief review which concentrates on recent studies in the field and emphasizes concepts of importance in detection, control, and prevention of cysticercosis. T. saginata cysticercosis in beef (beef measles) continues to be a concern in developed countries such as the United States, as well as in developing areas such as East Africa where the infection is widespread. The high standards of meat inspection in the United States have not succeeded in eliminating beef cysticercosis which is seen primarily in feedlot cattle originating in the southwestern U.S. However, it should not be viewed as a strictly regional problem, due to the widespread movement of animals and meat within the United States. Beef cysticercosis is costly due to the special treatment required of infected carcasses; serious effects on human health are rare. In contrast, T. solium cysticercosis in swine (pork measles) is rarely reported in areas such as the U.S., Canada, and most European countries, but is still a definite human health concern in Mexico, some other Latin American nations and parts of Africa and Asia. In addition to being a financial burden, T. solium is a serious public health threat in those countries where it is prevalent.

scholarly journals Genetic Vaccination against Murine Cysticercosis by Using a Plasmid Vector Carrying Taenia solium Paramyosin

2005 ◽  
Vol 73 (3) ◽  
pp. 1895-1897 ◽  
Author(s):  
Carlos F. Solís ◽  
Pedro Ostoa-Saloma ◽  
Verónica H. Lugo-Martínez ◽  
Stephen Albert Johnston ◽  
Juan Pedro Laclette
Keyword(s):  
Recombinant Protein ◽  
Taenia Solium ◽  
Parasite Burden ◽  
Plasmid Vector ◽  
Taenia Crassiceps ◽  
Amino Terminal ◽  
Terminal Fragment ◽  
Amino Terminal Fragment ◽  
Intraperitoneal Inoculation

ABSTRACT A plasmid vector carrying the immunoprotective amino-terminal fragment of Taenia solium paramyosin (VW2-1) was designed for genetic vaccination studies. Mice that were genetically immunized with VW2-1 and challenged by intraperitoneal inoculation of Taenia crassiceps cysticerci showed 43 to 48% reductions in the parasite burden, values which were similar to values obtained previously when the recombinant protein was used.

scholarly journals Characterization and Protective Potential of the Immune Response to Taenia solium Paramyosin in a Murine Model of Cysticercosis

2001 ◽  
Vol 69 (9) ◽  
pp. 5412-5416 ◽  
Author(s):  
José Vázquez-Talavera ◽  
Carlos F. Solı́s ◽  
Luis I. Terrazas ◽  
Juan P. Laclette
Keyword(s):  
Immune Response ◽  
Taenia Solium ◽  
Interleukin 2 ◽  
Parasite Burden ◽  
Full Length ◽  
Interleukin 4 ◽  
Protective Potential ◽  
Amino Terminal ◽  
Terminal Fragment ◽  
Amino Terminal Fragment

ABSTRACT Paramyosin has been proposed as a vaccine candidate in schistosomiasis and filariasis. However, limited information is available about its protective potential against cysticercosis and the immune response it induces. Immunization of mice with recombinant full-length paramyosin of Taenia solium (TPmy) results in about a 52% reduction in parasite burden after a subsequent challenge by intraperitoneal inoculation of Taenia crassiceps cysticerci. Immunization assays using recombinant fragments of TPmy, corresponding approximately to thirds on the amino, central, or carboxyl regions, suggest that protective epitopes are located mostly in the amino-end third. Proliferation assays using T cells obtained from mice immunized with the full-length recombinant TPmy also showed a preferential response to the amino-terminal fragment. In contrast, antibodies in the sera from these mice predominantly recognize epitopes located in the carboxyl-terminal fragment, being the immunoglobulin G1 subclass, the predominant antibody isotype. Characterization of the cellular immune response induced against the protective amino-terminal fragment reveals production of gamma interferon and interleukin-2, but not interleukin-4, suggesting a Th1-like profile.

Lycopene alleviates sulfamethoxazole-induced hepatotoxicity in grass carp (Ctenopharyngodon idellus) via suppression of oxidative stress, inflammation and apoptosis

2020 ◽  
Vol 11 (10) ◽  
pp. 8547-8559
Author(s):  
Hongjing Zhao ◽  
Yu Wang ◽  
Mengyao Mu ◽  
Menghao Guo ◽  
Hongxian Yu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Secondary Metabolites ◽  
Human Health ◽  
Grass Carp ◽  
Aquatic Environment ◽  
Ctenopharyngodon Idellus

Antibiotics are used worldwide to treat diseases in humans and other animals; most of them and their secondary metabolites are discharged into the aquatic environment, posing a serious threat to human health.

Emerging Nutrition Gaps in a World of Affluence - Micronutrient Intake and Status Globally

2011 ◽  
Vol 81 (4) ◽  
pp. 238-239 ◽  
Author(s):  
Manfred Eggersdorfer ◽  
Paul Walter
Keyword(s):  
Developing Countries ◽  
Human Health ◽  
Old Age ◽  
Molecular Basis ◽  
Health Benefit ◽  
Developed Countries ◽  
Micronutrient Deficiencies ◽  
New Science ◽  
Health And Nutrition ◽  
Micronutrient Intake

Nutrition is important for human health in all stages of life - from conception to old age. Today we know much more about the molecular basis of nutrition. Most importantly, we have learnt that micronutrients, among other factors, interact with genes, and new science is increasingly providing more tools to clarify this interrelation between health and nutrition. Sufficient intake of vitamins is essential to achieve maximum health benefit. It is well established that in developing countries, millions of people still suffer from micronutrient deficiencies. However, it is far less recognized that we face micronutrient insufficiencies also in developed countries.

Behavioral Testing of Mice Concerning Anxiety and Depression

2015 ◽  
Vol 223 (3) ◽  
pp. 151-156 ◽  
Author(s):  
Nina Schweinfurth ◽  
Undine E. Lang
Keyword(s):  
Environmental Influences ◽  
Sickness Behavior ◽  
Laboratory Research ◽  
Anxiety And Depression ◽  
Housing Conditions ◽  
Human Beings ◽  
Behavioral Testing ◽  
New Developments ◽  
Animal Trials ◽  
Resilience Factors

Abstract. In the development of new psychiatric drugs and the exploration of their efficacy, behavioral testing in mice has always shown to be an inevitable procedure. By studying the behavior of mice, diverse pathophysiological processes leading to depression, anxiety, and sickness behavior have been revealed. Moreover, laboratory research in animals increased at least the knowledge about the involvement of a multitude of genes in anxiety and depression. However, multiple new possibilities to study human behavior have been developed recently and improved and enable a direct acquisition of human epigenetic, imaging, and neurotransmission data on psychiatric pathologies. In human beings, the high influence of environmental and resilience factors gained scientific importance during the last years as the search for key genes in the development of affective and anxiety disorders has not been successful. However, environmental influences in human beings themselves might be better understood and controllable than in mice, where environmental influences might be as complex and subtle. The increasing possibilities in clinical research and the knowledge about the complexity of environmental influences and interferences in animal trials, which had been underestimated yet, question more and more to what extent findings from laboratory animal research translate to human conditions. However, new developments in behavioral testing of mice involve the animals’ welfare and show that housing conditions of laboratory mice can be markedly improved without affecting the standardization of results.

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