scholarly journals Complete Genome Sequencing of Two Equine Influenza A(H3N8) Virus Strains Isolated in Kazakhstan

2018 ◽  
Vol 6 (26) ◽  
Author(s):  
Yerbol Burashev ◽  
Vitaliy Strochkov ◽  
Kulyaisan Sultankulova ◽  
Mukhit Orynbayev ◽  
Abylay Sansyzbay ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Genome Sequencing ◽  
Complete Genome ◽  
Influenza A ◽  
Equine Influenza Virus ◽  
Equine Influenza ◽  
Complete Genome Sequencing ◽  
H3n8 Virus ◽  
Virus Strains

Here, we report the complete genome sequencing of strains A/equine/Kostanay/9/2012(H3N8) and A/equine/LKZ/9/2012(H3N8) of the equine influenza virus belonging to Florida sublineage, clade 2. The strains were isolated in 2012 in the northern and southern regions of Kazakhstan, respectively.

scholarly journals Complete Genomic Sequences of H3N8 Equine Influenza Virus Strains Used as Vaccine Strains in Japan

2018 ◽  
Vol 6 (12) ◽  
Author(s):  
Manabu Nemoto ◽  
Takashi Yamanaka ◽  
Hiroshi Bannai ◽  
Koji Tsujimura ◽  
Hiroshi Kokado
Keyword(s):  
Influenza Virus ◽  
Influenza A Virus ◽  
Influenza A ◽  
Animal Health ◽  
Genomic Sequences ◽  
Equine Influenza Virus ◽  
Equine Influenza ◽  
World Organization ◽  
Virus Strains ◽  
Complete Genomic

ABSTRACT We sequenced the eight segments of influenza A virus strains A/equine/Ibaraki/1/2007 and A/equine/Yokohama/aq13/2010, which are strains of the Florida sublineage clades 1 and 2 of the H3N8 subtype equine influenza virus. These strains have been used as vaccine strains in Japan since 2016 in accordance with World Organization for Animal Health (OIE) recommendations.

scholarly journals Genetic evolution of equine influenza virus strains (H3N8) isolated in France from 1967 to 2015 and the implications of several potential pathogenic factors

Virology ◽  
2017 ◽  
Vol 505 ◽  
pp. 210-217 ◽  
Author(s):  
Stéphanie Fougerolle ◽  
Loïc Legrand ◽  
Fanny Lecouturier ◽  
Corinne Sailleau ◽  
Romain Paillot ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Genetic Evolution ◽  
Equine Influenza Virus ◽  
Equine Influenza ◽  
Pathogenic Factors ◽  
Virus Strains

scholarly journals Mammalian Adaptation of an Avian Influenza A Virus Involves Stepwise Changes in NS1

2017 ◽  
Vol 92 (5) ◽  
Author(s):  
C. Chauché ◽  
A. Nogales ◽  
H. Zhu ◽  
D. Goldfarb ◽  
A. I. Ahmad Shanizza ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Immune Evasion ◽  
Influenza A ◽  
Nonstructural Protein ◽  
Ns1 Protein ◽  
Equine Influenza Virus ◽  
Influenza A Viruses ◽  
Equine Influenza ◽  
Nonstructural Protein 1 ◽  
Avian Origin

ABSTRACT Influenza A viruses (IAVs) are common pathogens of birds that occasionally establish endemic infections in mammals. The processes and mechanisms that result in IAV mammalian adaptation are poorly understood. The viral nonstructural 1 (NS1) protein counteracts the interferon (IFN) response, a central component of the host species barrier. We characterized the NS1 proteins of equine influenza virus (EIV), a mammalian IAV lineage of avian origin. We showed that evolutionarily distinct NS1 proteins counteract the IFN response using different and mutually exclusive mechanisms: while the NS1 proteins of early EIVs block general gene expression by binding to cellular polyadenylation-specific factor 30 (CPSF30), NS1 proteins from more evolved EIVs specifically block the induction of IFN-stimulated genes by interfering with the JAK/STAT pathway. These contrasting anti-IFN strategies are associated with two mutations that appeared sequentially and were rapidly selected for during EIV evolution, highlighting the importance of evolutionary processes in immune evasion mechanisms during IAV adaptation. IMPORTANCE Influenza A viruses (IAVs) infect certain avian reservoir species and occasionally transfer to and cause epidemics of infections in some mammalian hosts. However, the processes by which IAVs gain the ability to efficiently infect and transmit in mammals remain unclear. H3N8 equine influenza virus (EIV) is an avian-origin virus that successfully established a new lineage in horses in the early 1960s and is currently circulating worldwide in the equine population. Here, we analyzed the molecular evolution of the virulence factor nonstructural protein 1 (NS1) and show that NS1 proteins from different time periods after EIV emergence counteract the host innate immune response using contrasting strategies, which are associated with two mutations that appeared sequentially during EIV evolution. The results shown here indicate that the interplay between virus evolution and immune evasion plays a key role in IAV mammalian adaptation.

scholarly journals Whole-genome sequencing and antigenic analysis of the first equine influenza virus identified in Turkey

2018 ◽  
Vol 12 (3) ◽  
pp. 374-382 ◽  
Author(s):  
Jacinta Gahan ◽  
Marie Garvey ◽  
Sarah Gildea ◽  
Emre Gür ◽  
Anil Kagankaya ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Whole Genome ◽  
Equine Influenza Virus ◽  
Antigenic Analysis ◽  
Equine Influenza

scholarly journals Simultaneous and complete genome sequencing of influenza A and B with high coverage by Illumina MiSeq Platform

2013 ◽  
Vol 193 (2) ◽  
pp. 394-404 ◽  
Author(s):  
Wiriya Rutvisuttinunt ◽  
Piyawan Chinnawirotpisan ◽  
Sriluck Simasathien ◽  
Sanjaya K. Shrestha ◽  
In-Kyu Yoon ◽  
...  
Keyword(s):  
Genome Sequencing ◽  
Complete Genome ◽  
Influenza A ◽  
Illumina Miseq ◽  
High Coverage ◽  
Complete Genome Sequencing ◽  
Illumina Miseq Platform ◽  
Miseq Platform

scholarly journals Different pattern of haemagglutinin immunoreactivity of equine influenza virus strains isolated in Poland

2015 ◽  
Vol 59 (4) ◽  
pp. 463-466
Author(s):  
Małgorzata Kwaśnik ◽  
Ilona Marcelina Góra ◽  
Wojciech Rożek
Keyword(s):  
Monoclonal Antibody ◽  
Influenza Virus ◽  
Amino Acid ◽  
Point Mutations ◽  
Amino Acid Sequences ◽  
Equine Influenza Virus ◽  
Equine Influenza ◽  
Antigenic Sites ◽  
Virus Strains

Abstract The immunoreactivity of haemagglutinin (HA) polypeptides of equine influenza virus was compared among the strains isolated in Poland, using H3 monoclonal antibody. A stronger signal in immunoblot reaction was observed for A/equi/Pulawy/2008 HA polypeptides compared to A/equi/Pulawy/2006, despite the fact that both strains are phylogenetically closely related and belong to Florida clade 2 of American lineage. The strongest signal, observed in the case of A/equi/Pulawy/2008, seemed to be connected with the presence of G135, I213, E379, and/or V530 instead of R135, M213, G379, and I530 present in A/equi/Pulawy/2006 HA sequence. This implies that point mutations within amino acid sequences of HA polypeptides of equine influenza virus may change their immunoreactivity even when they are not located within five basic antigenic sites.

scholarly journals Antigenic and genetic variations in European and North American equine influenza virus strains (H3N8) isolated from 2006 to 2007

2009 ◽  
Vol 138 (1-2) ◽  
pp. 41-52 ◽  
Author(s):  
Neil A. Bryant ◽  
Adam S. Rash ◽  
Colin A. Russell ◽  
Julie Ross ◽  
Annie Cooke ◽  
...  
Keyword(s):  
Influenza Virus ◽  
North American ◽  
Genetic Variations ◽  
Equine Influenza Virus ◽  
Equine Influenza ◽  
Virus Strains
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