scholarly journals T and B cell population changes in young and in adult rats infected with Plasmodium berghei.

1976 ◽  
Vol 14 (1) ◽  
pp. 178-183 ◽  
Author(s):  
S M Gravely ◽  
J Hamburger ◽  
J P Kreier
Keyword(s):  
B Cell ◽  
Cell Population ◽  
Plasmodium Berghei ◽  
Population Changes ◽  
Adult Rats

Endothelial Cell Population Changes of Human Cornea During Life

1978 ◽  
Vol 96 (11) ◽  
pp. 2031-2035 ◽  
Author(s):  
A. Laule ◽  
M. K. Cable ◽  
C. E. Hoffman ◽  
C. Hanna
Keyword(s):  
Endothelial Cell ◽  
Cell Population ◽  
Human Cornea ◽  
Population Changes

Follicular Lymphoma in Staging Bone Marrow Specimens: Correlation of Histologic Findings With the Results of Flow Cytometry Immunophenotypic Analysis

2007 ◽  
Vol 131 (2) ◽  
pp. 282-287
Author(s):  
Dan Iancu ◽  
Suyang Hao ◽  
Pei Lin ◽  
S. Keith Anderson ◽  
Jeffrey L. Jorgensen ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Follicular Lymphoma ◽  
B Cell ◽  
Bone Marrow Biopsy ◽  
Cell Population ◽  
Color Flow ◽  
Flow Cytometric Immunophenotyping ◽  
Histologic Evidence ◽  
Flow Cytometric ◽  
Biopsy Specimens

Abstract Context.—Bone marrow (BM) examination is part of the staging workup of lymphoma patients. Few studies have compared BM histologic findings with results of flow cytometric immunophenotyping analysis in follicular lymphoma (FL) patients. Objective.—To correlate histologic findings with immunophenotypic data in staging BM biopsy and aspiration specimens of FL patients. Design.—Bone marrow biopsy specimens of untreated FL patients were reviewed. Histologic findings were correlated with 3-color flow cytometric immunophenotyping results on corresponding BM aspirates. Results.—Bone marrow biopsy specimens (with or without aspirates) of 114 patients with histologic evidence of FL in BM were reviewed. There were 76 bilateral and 38 unilateral biopsies performed, resulting in 190 specimens: 187 involved by FL and 3 negative (in patients with a positive contralateral specimen). The extent of BM involvement was <5% in 32 (17.1%), ≥5% and ≤25% in 102 (54.6%), >25% and ≤50% in 27 (14.4%), and >50% in 26 (13.9%) specimens. The pattern of involvement was purely paratrabecular in 81 (43.3%), mixed in 80 (42.8%), and purely nonparatrabecular in 26 (13.9%). Immunophenotyping was only performed unilaterally, on BM aspirates of 92 patients, and was positive for a monoclonal B-cell population in 53 (57.6%) patients. Immunophenotyping was more often negative when biopsy specimens showed FL with a purely paratrabecular pattern. For comparison, we assessed 163 FL patients without histologic evidence of FL in BM also analyzed by flow cytometric immunophenotyping. A monoclonal B-cell population was identified in 5 patients (3%). Conclusions.—Our data suggest that 3-color flow cytometric immunophenotyping adds little information to the evaluation of staging BM specimens of FL patients.

B Cell Production in Adult Rats

1985 ◽  
pp. 65-71
Author(s):  
H. Bazin ◽  
B. Platteau ◽  
I. C. M. MacLennan ◽  
N. S. A. Stuart ◽  
M. Khan ◽  
...  
Keyword(s):  
B Cell ◽  
Adult Rats ◽  
Cell Production

Regulation of the Size of the Recirculating B Cell Pool of Adult Rats

1958 ◽  
pp. 593-601
Author(s):  
J. Lortan ◽  
D. Gray ◽  
D. S. Kumararatne ◽  
B. Platteau ◽  
H. Bazin ◽  
...  
Keyword(s):  
B Cell ◽  
Adult Rats ◽  
Cell Pool

scholarly journals Specific induction of double negative B cells during protective and pathogenic immune responses

2020 ◽  
Author(s):  
Christoph Ruschil ◽  
Gisela Gabernet ◽  
Gildas Lepennetier ◽  
Simon Heumos ◽  
Miriam Kaminski ◽  
...  
Keyword(s):  
B Cells ◽  
B Cell ◽  
Cell Population ◽  
Vaccine Antigen ◽  
Double Negative ◽  
Humoral Immune ◽  
Follicular Maturation ◽  
Inflammatory Conditions ◽  
Tick Borne Encephalitis Virus ◽  
B Cell Subsets

1AbstractDouble negative (DN) (CD19+CD20lowCD27−IgD−) B cells are expanded in patients with autoimmune and infectious diseases; however their role in the humoral immune response remains unclear. Using systematic flow cytometric analyses of peripheral blood B cell subsets, we observed an inflated DN B cell population in patients with variety of active inflammatory conditions: myasthenia gravis, Guillain-Barré syndrome, neuromyelitis optica spectrum disorder, meningitis/encephalitis, and rheumatic disorders. Furthermore, we were able to induce DN B cells in healthy subjects following vaccination against influenza and tick borne encephalitis virus. Transcriptome analysis revealed a gene expression profile in DN B cells that clustered with naïve B cells, memory B cells, and plasmablasts. Immunoglobulin VH transcriptome sequencing and analysis of recombinant antibodies revealed clonal expansion of DN B cells, that were targeted against the vaccine antigen. Our study suggests that DN B cells are expanded in multiple inflammatory neurologic diseases and represent an inducible B cell population that responds to antigenic stimulation, possibly through an extra-follicular maturation pathway.

scholarly journals PB2112 COEXISTENCE OF MONOCLONAL B- CELL POPULATION IN PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA; INCIDENCE, IMMUNOPHENOTYPING AND CLINICAL CHARACTERIZATION

HemaSphere ◽  
2019 ◽  
Vol 3 (S1) ◽  
pp. 951
Author(s):  
Y. Cohen ◽  
I. Cohen ◽  
C. Perry ◽  
I. Avivi ◽  
S. Kay ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
B Cell ◽  
Cell Population ◽  
Newly Diagnosed

scholarly journals Characterization of the Highly Prevalent Regulatory CD24hiCD38hi B-Cell Population in Human Cord Blood

2017 ◽  
Vol 8 ◽  
Author(s):  
Ana Esteve-Solé ◽  
Irene Teixidó ◽  
Angela Deyà-Martínez ◽  
Jordi Yagüe ◽  
Ana M. Plaza-Martín ◽  
...  
Keyword(s):  
Cord Blood ◽  
B Cell ◽  
Cell Population ◽  
Human Cord Blood
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