scholarly journals A Calcium-Calmodulin Antagonist Blocks Experimental Vibrio vulnificus Cytolysin-Induced Lethality in an Experimental Mouse Model

2004 ◽  
Vol 72 (10) ◽  
pp. 6157-6159 ◽  
Author(s):  
Young-Rae Lee ◽  
Kwang-Hyun Park ◽  
Zhao-Zhen Lin ◽  
Young-Jong Kho ◽  
Jin-Woo Park ◽  
...  
Keyword(s):  
Survival Rate ◽  
Mouse Model ◽  
Vibrio Vulnificus ◽  
Calmodulin Antagonist ◽  
Experimental Mouse Model ◽  
Experimental Mouse

ABSTRACT We demonstrated that trifluoperazine, a calcium-calmodulin antagonist, blocked the hyperpermeability induced by Vibrio vulnificus cytolysin in in vitro-modeled endothelium and prevented the deaths of mice. Furthermore, compared to tetracycline alone, tetracycline combined with trifluoperazine enhanced the survival rate of V. vulnificus-infected mice, indicating the role of the cytolysin as an important factor in pathogenesis.

scholarly journals The role of oxidative stress in α-amanitin-induced hepatotoxicityin an experimental mouse model

2017 ◽  
Vol 47 ◽  
pp. 318-325
Author(s):  
Zerrin Defne DÜNDAR ◽  
Mehmet ERGİN ◽  
İbrahim KILINÇ ◽  
Tamer ÇOLAK ◽  
Pembe OLTULU ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mouse Model ◽  
Experimental Mouse Model ◽  
Experimental Mouse

The Role of Aging, High Fat Diet and Blue Light Exposure in an Experimental Mouse Model for Basal Laminar Deposit Formation

2002 ◽  
Vol 75 (5) ◽  
pp. 543-553 ◽  
Author(s):  
Scott W. Cousins ◽  
Diego G. Espinosa-Heidmann ◽  
Anastasia Alexandridou ◽  
John Sall ◽  
Sander Dubovy ◽  
...  
Keyword(s):  
Mouse Model ◽  
Blue Light ◽  
High Fat Diet ◽  
Light Exposure ◽  
High Fat ◽  
Deposit Formation ◽  
Experimental Mouse Model ◽  
Experimental Mouse

Regulatory T cells expanded by rapamycin in vitro suppress colitis in an experimental mouse model

2011 ◽  
Vol 47 (4) ◽  
pp. 366-376 ◽  
Author(s):  
Haruei Ogino ◽  
Kazuhiko Nakamura ◽  
Tsutomu Iwasa ◽  
Eikich Ihara ◽  
Hirotada Akiho ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Mouse Model ◽  
Experimental Mouse Model ◽  
Experimental Mouse

Ketogenic diet impairs Mycobacterium ulcerans growth and toxin production, enhancing hosts’ response to the infection in an experimental mouse model

2021 ◽  
Author(s):  
Mélanie Foulon ◽  
Marie Robbe-Saule ◽  
Lucille Esnault ◽  
Marine Malloci ◽  
Anthony Mery ◽  
...  
Keyword(s):  
Mouse Model ◽  
Ketogenic Diet ◽  
Buruli Ulcer ◽  
Mycobacterium Ulcerans ◽  
World Health ◽  
Ketogenic Diets ◽  
Experimental Mouse Model ◽  
Experimental Mouse ◽  
The Impact

Abstract Ketogenic diets have been used to treat diverse conditions, and there is growing evidence of their benefits for tissue repair and in inflammatory disease treatment. However, their role in infectious diseases has been little studied. Buruli ulcer (Mycobacterium ulcerans infection) is a chronic infectious disease characterized by large skin ulcerations caused by mycolactone, the major virulence factor of the bacillus. Here, we investigated the impact of ketogenic diet on this cutaneous disease in an experimental mouse model. This diet prevented ulceration, by modulating bacterial growth and host inflammatory response. β-hydroxybutyrate, the major ketone body produced during ketogenic diet and diffusing in tissues, impeded M. ulcerans growth and mycolactone production in vitro underlying its potential key role in infection. These results pave the way for the development of new patient management strategies involving shorter courses of treatment and improving wound healing, in line with the major objectives of the World Health Organization.

scholarly journals In Vitro Synergy and In Vivo Activity of Tigecycline-Ciprofloxacin Combination Therapy against Vibrio vulnificus Sepsis

2019 ◽  
Vol 63 (10) ◽  
Author(s):  
Seong Eun Kim ◽  
Hee Kyung Kim ◽  
Su-Mi Choi ◽  
Yohan Yu ◽  
Uh Jin Kim ◽  
...  
Keyword(s):  
Survival Rate ◽  
Mortality Rate ◽  
Combination Therapy ◽  
Combination Treatment ◽  
Vibrio Vulnificus ◽  
Antibiotic Regimen ◽  
Content Type ◽  
Time Kill

ABSTRACT The mortality rate associated with Vibrio vulnificus sepsis remains high. An in vitro time-kill assay revealed synergism between tigecycline and ciprofloxacin. The survival rate was significantly higher in mice treated with tigecycline plus ciprofloxacin than in mice treated with cefotaxime plus minocycline. Thus, combination treatment with tigecycline-ciprofloxacin may be an effective novel antibiotic regimen for V. vulnificus sepsis.

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