scholarly journals Membrane Lipid Biosynthesis in Acholeplasma laidlawii B: Elongation of Medium- and Long-Chain Exogenous Fatty Acids in Growing Cells

1978 ◽  
Vol 133 (1) ◽  
pp. 66-74 ◽  
Author(s):  
Yuji Saito ◽  
John R. Silvius ◽  
Ronald N. McElhaney
Keyword(s):  
Fatty Acids ◽  
Membrane Lipid ◽  
Lipid Biosynthesis ◽  
Acholeplasma Laidlawii ◽  
Long Chain

Membrane lipid biosynthesis in Acholeplasma laidlawii B

1977 ◽  
Vol 182 (2) ◽  
pp. 455-464 ◽  
Author(s):  
John R. Silvius ◽  
Yuji Saito ◽  
Ronald N. McElhaney
Keyword(s):  
Membrane Lipid ◽  
Lipid Biosynthesis ◽  
Acholeplasma Laidlawii

Very-long-chain fatty acids (VLCFAs) in plant response to stress

2020 ◽  
Vol 47 (8) ◽  
pp. 695
Author(s):  
Anatoly V. Zhukov ◽  
Maria Shumskaya
Keyword(s):  
Fatty Acids ◽  
Abiotic Factors ◽  
Membrane Lipid ◽  
Current Data ◽  
Stress Conditions ◽  
Long Chain Fatty Acids ◽  
Functional Roles ◽  
High And Low Temperatures ◽  
Long Chain ◽  
Chain Fatty Acids

Plant growth is affected by various stresses leading to changes in metabolism. Stress conditions include a variety of biotic and abiotic factors such as pathogens, drought, high and low temperatures and heavy metals. Among multiple physiological responses to stress, there is an adaptive modification in membrane lipid constituents. In particular, the composition of membrane very-long-chain fatty acids (VLCFAs) changes both qualitatively and quantitatively. Here, we evaluate the current data on the effects of stress on plant VLCFAs composition. In summary, some stress conditions lead to an increase of the total amount of saturated and, in certain cases, unsaturated VLCFAs. Currently, it is not completely clear how these molecules participate in the biology of plant cell membranes. Their possible functional roles are discussed.

scholarly journals Omega-3 Long Chain Polyunsaturated Fatty Acids as Sensitizing Agents and Multidrug Resistance Revertants in Cancer Therapy

2017 ◽  
Author(s):  
Paola Antonia Corsetto ◽  
Irma Colombo ◽  
Joanna Kopecka ◽  
Angela Maria Rizzo ◽  
Chiara Riganti
Keyword(s):  
Fatty Acids ◽  
Multidrug Resistance ◽  
Polyunsaturated Fatty Acids ◽  
Cellular Proliferation ◽  
Chemical Properties ◽  
Membrane Lipid ◽  
Drug Uptake ◽  
Omega 3 ◽  
Acquired Drug Resistance ◽  
Long Chain

The efficacy of chemotherapy depends on sensitivity and intrinsic or acquired drug resistance of cancer cells. The n-3 long chain polyunsaturated fatty acids (n-3 LCPUFAs) are considered chemosensitizing agents and revertants of multidrug resistance by pleiotropic mechanisms. The specific mechanisms are not fully understood, but nowadays, it is widely accepted that there are a complex network of mechanisms, including alteration in gene expression, modulation of cellular proliferation and differentiation, induction of apoptosis, generation of reactive oxygen species and lipid peroxidation. A crucial mechanism in the control of cell drug uptake and efflux is related to n-3 LCPUFA influence on membrane lipid composition. The incorporation of docosahexaenoic acid in the lipid rafts produces significant changes in their physical-chemical properties affecting content and functions of transmembrane proteins, such as growth factors, receptors and ATP-binding cassette transporters. Of note, n-3 LCPUFAs often impact on the lipid compositions more in chemoresistant cells than in chemosensitive cells, suggesting their adjuvant role in cancer treatment.

Membrane lipid biosynthesis in Acholeplasma laidlawii B

1977 ◽  
Vol 182 (2) ◽  
pp. 443-454 ◽  
Author(s):  
Yuji Saito ◽  
John R. Silvius ◽  
Ronald N. McElhaney
Keyword(s):  
Membrane Lipid ◽  
Lipid Biosynthesis ◽  
Acholeplasma Laidlawii
Sign in / Sign up

Export Citation Format

Share Document