Francisella philomiragia Bacteremia in a Patient with Acute Respiratory Insufficiency and Acute-on-Chronic Kidney Disease

Francisella philomiragiais a very uncommon pathogen of humans. Diseases caused by it are protean and have been reported largely in near-drowning victims and those with chronic granulomatous disease. We present a case ofF. philomiragiapneumonia with peripheral edema and bacteremia in a renal transplant patient and review the diverse reports ofF. philomiragiainfections.

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First Case of Disseminated Infection with Nocardia cerradoensis in a Human

Journal of Clinical Microbiology ◽

10.1128/jcm.02979-14 ◽

2015 ◽

Vol 53 (3) ◽

pp. 1034-1037 ◽

Cited By ~ 12

Author(s):

Caroline Piau ◽

Mallorie Kerjouan ◽

Marc Le Mouel ◽

Solene Patrat-Delon ◽

Pierre-Louis Henaux ◽

...

Keyword(s):

Renal Transplant ◽

16S Rrna ◽

Species Identification ◽

Antibiotic Treatment ◽

Renal Transplant Patient ◽

Transplant Patient ◽

Brain Biopsy ◽

Content Type ◽

Disseminated Infection ◽

First Case

Here we report in a human, a renal transplant patient, the first disseminated infection withNocardia cerradoensis, isolated after a brain biopsy. Species identification was based on 16S rRNA,gyrB, andhsp65gene analyses. Antibiotic treatment was successful by combining carbapenems and aminoglycosides and then switching to oral trimethoprim-sulfamethoxazole.

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Successful Treatment of Bloodstream Infection Due to Metallo-β-Lactamase-Producing Stenotrophomonas maltophilia in a Renal Transplant Patient

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.00264-16 ◽

2016 ◽

Vol 60 (9) ◽

pp. 5130-5134 ◽

Cited By ~ 34

Author(s):

Maria F. Mojica ◽

Christopher P. Ouellette ◽

Amy Leber ◽

M. Brian Becknell ◽

Monica I. Ardura ◽

...

Keyword(s):

Renal Transplant ◽

Stenotrophomonas Maltophilia ◽

Conventional Treatment ◽

Renal Transplant Patient ◽

Transplant Patient ◽

Opportunistic Pathogen ◽

Multidrug Resistant ◽

Content Type ◽

Colistimethate Sodium ◽

Novel Drug

ABSTRACTStenotrophomonas maltophiliais an emerging multidrug-resistant (MDR) opportunistic pathogen for which new antibiotic options are urgently needed. We report our clinical experience treating a 19-year-old renal transplant recipient who developed prolonged bacteremia due to metallo-β-lactamase-producingS. maltophiliarefractory to conventional treatment. The infection recurred despite a prolonged course of colistimethate sodium (colistin) but resolved with the use of a novel drug combination with clinical efficacy against the patient'sS. maltophiliaisolate.

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Failure of Posaconazole Therapy in a Renal Transplant Patient with Invasive Aspergillosis Due to Aspergillus fumigatus with Attenuated Susceptibility to Posaconazole

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.01544-10 ◽

2011 ◽

Vol 55 (7) ◽

pp. 3564-3566 ◽

Cited By ~ 27

Author(s):

Saskia Kuipers ◽

Roger J. M. Brüggemann ◽

Ruud G. L. de Sévaux ◽

John P. F. A. Heesakkers ◽

Willem J. G. Melchers ◽

...

Keyword(s):

Renal Transplant ◽

Invasive Aspergillosis ◽

Aspergillus Fumigatus ◽

Drug Exposure ◽

Renal Transplant Patient ◽

Transplant Patient ◽

Kidney Transplant Recipient ◽

Time Curve ◽

Content Type ◽

Concentration Time

ABSTRACTWe report the case of a kidney transplant recipient with invasive aspergillosis due toAspergillus fumigatusresistant to voriconazole and intermediately susceptible to posaconazole who failed posaconazole therapy. Plasma posaconazole concentrations indicated an unfavorable ratio of the area under the concentration-time curve over the MIC. Posaconazole should be used with caution for invasive aspergillosis caused by strains with attenuated posaconazole susceptibility, as drug exposure may be inadequate, resulting in therapeutic failure.

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A Dutch Case Report of Successful Treatment of Chronic Relapsing Urinary Tract Infection with Bacteriophages in a Renal Transplant Patient

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.01281-19 ◽

2019 ◽

Vol 64 (1) ◽

Cited By ~ 9

Author(s):

Saskia Kuipers ◽

Mike M. Ruth ◽

Mike Mientjes ◽

Ruud G. L. de Sévaux ◽

Jakko van Ingen

Keyword(s):

Urinary Tract Infection ◽

Urinary Tract ◽

Renal Transplant ◽

Tract Infection ◽

Renal Transplant Patient ◽

Transplant Patient ◽

Recurrent Urinary Tract Infection ◽

Gram Negative ◽

Content Type ◽

Transplant Patients

ABSTRACT We report a case of a 58-year-old renal transplant patient who developed a recurrent urinary tract infection with an extended-spectrum β-lactamase (ESBL)-positive Klebsiella pneumoniae strain in the first month posttransplant. Even though it tested susceptible to carbapenems and despite repeated meropenem treatment, his infection recurred. The infection eventually evolved into epididymitis that was successfully treated with meropenem and bacteriophages. This case demonstrates the difficulty of treating relapsing ESBL-positive Gram-negative infections in renal transplant patients.

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Strongyloides Hyperinfection in a Renal Transplant Patient: Always Be on the Lookout

Case Reports in Infectious Diseases ◽

10.1155/2017/2953805 ◽

2017 ◽

Vol 2017 ◽

pp. 1-4

Author(s):

Murtaza Mazhar ◽

Ijlal Akbar Ali ◽

Nelson Iván Agudelo Higuita

Keyword(s):

Renal Transplant ◽

Kidney Disease ◽

Renal Transplant Patient ◽

Transplant Patient ◽

Strongyloides Stercoralis ◽

The United States ◽

Stool Examination ◽

Peripheral Eosinophilia ◽

Adult Polycystic Kidney Disease ◽

Prisoner Of War

We present a case of a 71-year-old Vietnamese man with chronic kidney disease secondary to adult polycystic kidney disease. He had been a prisoner of war before undergoing a successful cadaveric renal transplant in the United States. He presented to clinic one year after the transplant with gross hematuria, productive cough, intermittent chills, and weight loss. Long standing peripheral eosinophilia of 600–1200/μL triggered further evaluation. A wet mount of stool revealedStrongyloides stercoralislarvae. A computed tomography (CT) of chest showed findings suggestive of extension of the infection to the lungs. The patient was treated with a three-week course of ivermectin with complete resolution of signs, symptoms, peripheral eosinophilia, and the positive IgG serology. Strongyloides infection in renal transplant patient is very rare and often presents with hyperinfection, associated with high mortality rates. The American Transplant Society recommends pretransplant screening with stool examination andStrongyloides stercoralisantibody in recipients and donors from endemic areas or with eosinophilia. It is imperative that healthcare professionals involved in the care of these individuals be cognizant of these recommendations as it is a very preventable and treatable entity.

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