scholarly journals Successful Treatment of Bloodstream Infection Due to Metallo-β-Lactamase-Producing Stenotrophomonas maltophilia in a Renal Transplant Patient

2016 ◽  
Vol 60 (9) ◽  
pp. 5130-5134 ◽  
Author(s):  
Maria F. Mojica ◽  
Christopher P. Ouellette ◽  
Amy Leber ◽  
M. Brian Becknell ◽  
Monica I. Ardura ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Stenotrophomonas Maltophilia ◽  
Conventional Treatment ◽  
Renal Transplant Patient ◽  
Transplant Patient ◽  
Opportunistic Pathogen ◽  
Multidrug Resistant ◽  
Content Type ◽  
Colistimethate Sodium ◽  
Novel Drug

ABSTRACTStenotrophomonas maltophiliais an emerging multidrug-resistant (MDR) opportunistic pathogen for which new antibiotic options are urgently needed. We report our clinical experience treating a 19-year-old renal transplant recipient who developed prolonged bacteremia due to metallo-β-lactamase-producingS. maltophiliarefractory to conventional treatment. The infection recurred despite a prolonged course of colistimethate sodium (colistin) but resolved with the use of a novel drug combination with clinical efficacy against the patient'sS. maltophiliaisolate.

scholarly journals First Case of Disseminated Infection with Nocardia cerradoensis in a Human

2015 ◽  
Vol 53 (3) ◽  
pp. 1034-1037 ◽  
Author(s):  
Caroline Piau ◽  
Mallorie Kerjouan ◽  
Marc Le Mouel ◽  
Solene Patrat-Delon ◽  
Pierre-Louis Henaux ◽  
...  
Keyword(s):  
Renal Transplant ◽  
16S Rrna ◽  
Species Identification ◽  
Antibiotic Treatment ◽  
Renal Transplant Patient ◽  
Transplant Patient ◽  
Brain Biopsy ◽  
Content Type ◽  
Disseminated Infection ◽  
First Case

Here we report in a human, a renal transplant patient, the first disseminated infection withNocardia cerradoensis, isolated after a brain biopsy. Species identification was based on 16S rRNA,gyrB, andhsp65gene analyses. Antibiotic treatment was successful by combining carbapenems and aminoglycosides and then switching to oral trimethoprim-sulfamethoxazole.

Rigorous Vibrio vulnificus Soft Tissue Infection of the Lower Leg in a Renal Transplant Patient Managed by Vacuum Therapy and Autologous Growth Factors

2009 ◽  
Vol 13 (4) ◽  
pp. 209-214 ◽  
Author(s):  
Elias Thodis ◽  
Pelagia Kriki ◽  
Despoina Kakagia ◽  
Ploumis Passadakis ◽  
Marios Theodoridis ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Renal Transplant ◽  
Renal Transplant Patient ◽  
Transplant Patient ◽  
Vibrio Vulnificus ◽  
Healing Process ◽  
Opportunistic Pathogen ◽  
Vacuum Therapy ◽  
Autologous Platelet Concentrate ◽  
Immunosuppressed Patients

Background: Vibrio vulnificus is a gram-negative marine bacterium that grows well in coastal waters. It is an opportunistic pathogen that can cause serious life-threatening infections in patients with certain health conditions. Vibrio-induced wound infections in immunosuppressed patients are difficult to treat because the healing process may be significantly delayed. Reconstructive surgery may not be successful in early treatment as skin grafts are likely to fail, and there may be increased morbidity of donor sites of grafts or flaps. Objective: Herein a case of septicemia and wound necrosis owing to V. vulnificus wound infection in a renal transplant patient is reported. Method: To conservatively yet adequately débride the wound bed, stimulate angiogenesis, and accelerate granulation, vacuum-assisted closure was employed. Granulation was further enhanced by autologous platelet concentrate spray, which has also been reported to increase the epithelialization rate. Result: Complete epithelialization of the wound was achieved 4 weeks after completion of treatment. Conclusion: Noninvasive advanced modalities may be employed to successfully treat infectious soft tissue deficits in immunocompromised patients.

scholarly journals Avibactam Restores the Susceptibility of Clinical Isolates of Stenotrophomonas maltophilia to Aztreonam

2017 ◽  
Vol 61 (10) ◽  
Author(s):  
Maria F. Mojica ◽  
Krisztina M. Papp-Wallace ◽  
Magdalena A. Taracila ◽  
Melissa D. Barnes ◽  
Joseph D. Rutter ◽  
...  
Keyword(s):  
Stenotrophomonas Maltophilia ◽  
Opportunistic Pathogen ◽  
Multidrug Resistant ◽  
World Health ◽  
Combination Therapies ◽  
Content Type ◽  
Medical Need ◽  
The World ◽  
Health Organization

ABSTRACT Stenotrophomonas maltophilia is an emerging opportunistic pathogen, classified by the World Health Organization as one of the leading multidrug-resistant organisms in hospital settings. The need to discover novel compounds and/or combination therapies for S. maltophilia is urgent. We demonstrate the in vitro efficacy of aztreonam-avibactam (ATM-AVI) against S. maltophilia and kinetically characterize the inhibition of the L2 β-lactamase by avibactam. ATM-AVI overcomes aztreonam resistance in selected clinical strains of S. maltophilia, addressing an unmet medical need.

scholarly journals Characterization of Maltocin P28, a Novel Phage Tail-Like Bacteriocin from Stenotrophomonas maltophilia

2013 ◽  
Vol 79 (18) ◽  
pp. 5593-5600 ◽  
Author(s):  
Jian Liu ◽  
Peng Chen ◽  
Congyi Zheng ◽  
Yu-Ping Huang
Keyword(s):  
Gene Cluster ◽  
Stenotrophomonas Maltophilia ◽  
Opportunistic Pathogen ◽  
Multidrug Resistant ◽  
Gene Organization ◽  
Open Reading Frames ◽  
Proteinase K ◽  
Major Protein ◽  
Content Type ◽  
Phage Tail

ABSTRACTStenotrophomonas maltophiliais an important global opportunistic pathogen for which limited therapeutics are available because of the emergence of multidrug-resistant strains. A novel bacteriocin, maltocin P28, which is produced byS. maltophiliastrain P28, may be the first identified phage tail-like bacteriocin fromS. maltophilia. Maltocin P28 resembles a contractile but nonflexible phage tail structure based on electron microscopy, and it is sensitive to trypsin, proteinase K, and heat. SDS-PAGE analysis of maltocin P28 revealed two major protein bands of approximately 43 and 20 kDa. The N-terminal amino acid residues of these two major subunits were sequenced, and the maltocin P28 gene cluster was located on theS. maltophiliaP28 chromosome. Our sequence analysis results indicate that this maltocin gene cluster consists of 23 open reading frames (ORFs), and that its gene organization is similar to that of the P2 phage genome and R2 pyocin gene cluster. ORF17 and ORF18 encode the two major structural proteins, which correspond to gpFI (tail sheath) and gpFII (tail tube) of P2 phage, respectively. We found that maltocin P28 had bactericidal activity against 38 of 81 testedS. maltophiliastrains. Therefore, maltocin P28 is a promising therapeutic substitute for antibiotics forS. maltophiliainfections.

scholarly journals Failure of Posaconazole Therapy in a Renal Transplant Patient with Invasive Aspergillosis Due to Aspergillus fumigatus with Attenuated Susceptibility to Posaconazole

2011 ◽  
Vol 55 (7) ◽  
pp. 3564-3566 ◽  
Author(s):  
Saskia Kuipers ◽  
Roger J. M. Brüggemann ◽  
Ruud G. L. de Sévaux ◽  
John P. F. A. Heesakkers ◽  
Willem J. G. Melchers ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Invasive Aspergillosis ◽  
Aspergillus Fumigatus ◽  
Drug Exposure ◽  
Renal Transplant Patient ◽  
Transplant Patient ◽  
Kidney Transplant Recipient ◽  
Time Curve ◽  
Content Type ◽  
Concentration Time

ABSTRACTWe report the case of a kidney transplant recipient with invasive aspergillosis due toAspergillus fumigatusresistant to voriconazole and intermediately susceptible to posaconazole who failed posaconazole therapy. Plasma posaconazole concentrations indicated an unfavorable ratio of the area under the concentration-time curve over the MIC. Posaconazole should be used with caution for invasive aspergillosis caused by strains with attenuated posaconazole susceptibility, as drug exposure may be inadequate, resulting in therapeutic failure.

scholarly journals A Dutch Case Report of Successful Treatment of Chronic Relapsing Urinary Tract Infection with Bacteriophages in a Renal Transplant Patient

2019 ◽  
Vol 64 (1) ◽  
Author(s):  
Saskia Kuipers ◽  
Mike M. Ruth ◽  
Mike Mientjes ◽  
Ruud G. L. de Sévaux ◽  
Jakko van Ingen
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Renal Transplant ◽  
Tract Infection ◽  
Renal Transplant Patient ◽  
Transplant Patient ◽  
Recurrent Urinary Tract Infection ◽  
Gram Negative ◽  
Content Type ◽  
Transplant Patients

ABSTRACT We report a case of a 58-year-old renal transplant patient who developed a recurrent urinary tract infection with an extended-spectrum β-lactamase (ESBL)-positive Klebsiella pneumoniae strain in the first month posttransplant. Even though it tested susceptible to carbapenems and despite repeated meropenem treatment, his infection recurred. The infection eventually evolved into epididymitis that was successfully treated with meropenem and bacteriophages. This case demonstrates the difficulty of treating relapsing ESBL-positive Gram-negative infections in renal transplant patients.

scholarly journals Draft Genome Sequence of the Multidrug-Resistant Strain Stenotrophomonas maltophilia N0320, Isolated from a Commercial Nanoparticle Product

2021 ◽  
Vol 10 (43) ◽  
Author(s):  
Miseon Park ◽  
Christine V. Summage-West ◽  
Lillie M. Sims ◽  
Sung-Guk Kim
Keyword(s):  
Genome Sequence ◽  
Resistant Strain ◽  
Stenotrophomonas Maltophilia ◽  
Draft Genome ◽  
Opportunistic Pathogen ◽  
Multidrug Resistant ◽  
Draft Genome Sequence ◽  
Hospital Infections ◽  
Content Type ◽  
Multidrug Resistant Strain

Stenotrophomonas maltophilia is an emerging opportunistic pathogen that is frequently associated with hospital infections. We report the 4.8-Mbp draft genome sequence of the oxidase-positive S. maltophilia strain N0320, an isolate from a commercial hydroxyapatite nanoparticle product.

scholarly journals Francisella philomiragia Bacteremia in a Patient with Acute Respiratory Insufficiency and Acute-on-Chronic Kidney Disease

2015 ◽  
Vol 53 (12) ◽  
pp. 3947-3950 ◽  
Author(s):  
Ryan F. Relich ◽  
Romney M. Humphries ◽  
H. Reid Mattison ◽  
Jessica E. Miles ◽  
Edward R. Simpson ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Transplant ◽  
Kidney Disease ◽  
Chronic Granulomatous Disease ◽  
Renal Transplant Patient ◽  
Transplant Patient ◽  
Granulomatous Disease ◽  
Content Type ◽  
Near Drowning ◽  
Acute Respiratory Insufficiency

Francisella philomiragiais a very uncommon pathogen of humans. Diseases caused by it are protean and have been reported largely in near-drowning victims and those with chronic granulomatous disease. We present a case ofF. philomiragiapneumonia with peripheral edema and bacteremia in a renal transplant patient and review the diverse reports ofF. philomiragiainfections.

scholarly journals Complete Genome Sequence of Stenotrophomonas maltophilia Podophage Ponderosa

2019 ◽  
Vol 8 (39) ◽  
Author(s):  
Alejandra Marquez ◽  
Heather Newkirk ◽  
Russell Moreland ◽  
Carlos F. Gonzalez ◽  
Mei Liu ◽  
...  
Keyword(s):  
Complete Genome Sequence ◽  
Complete Genome ◽  
Stenotrophomonas Maltophilia ◽  
Opportunistic Pathogen ◽  
Multidrug Resistant ◽  
Negative Bacterium ◽  
Protein Coding ◽  
Gram Negative ◽  
Content Type ◽  
Protein Coding Genes

Stenotrophomonas maltophilia is a Gram-negative bacterium that is emerging as a multidrug-resistant global opportunistic pathogen. Here, we describe the genome of the T7-like S. maltophilia podophage Ponderosa, with 54 predicted protein-coding genes and a 493-bp terminal repeat.

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