scholarly journals Clinical Significance and Mechanism of Gas Formation of Pyogenic Liver Abscess Due to Klebsiella pneumoniae

2004 ◽  
Vol 42 (6) ◽  
pp. 2783-2785 ◽  
Author(s):  
H.-L. Lee ◽  
H.-C. Lee ◽  
H.-R. Guo ◽  
W.-C. Ko ◽  
K.-W. Chen
Keyword(s):  
Klebsiella Pneumoniae ◽  
Clinical Significance ◽  
Liver Abscess ◽  
Pyogenic Liver Abscess ◽  
Gas Formation

scholarly journals Importation of Entamoeba histolytica and predominance of Klebsiella pneumoniae in liver abscesses: a 7-year retrospective cohort study from the United Arab Emirates

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Hussam Mousa ◽  
Ghada Salameh Mohammed Al-Bluwi ◽  
Zainab Fathi Mohammed Al Drini ◽  
Huda Imam Gasmelseed ◽  
Jamal Aldeen Alkoteesh ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
United Arab Emirates ◽  
Liver Abscess ◽  
Hospital Admissions ◽  
Indian Subcontinent ◽  
Pyogenic Liver Abscess ◽  
Primary Diagnosis ◽  
Incidence Rates ◽  
Liver Abscesses ◽  
Potential Risk Factors

Abstract Background There is a dearth of information on liver abscesses in the United Arab Emirates. Herein, we describe the clinical features of liver abscesses and determine their incidence rates and clinical outcomes. Methods We retrospectively reviewed the clinical charts of adult patients with a primary diagnosis of liver abscess at a major hospital over a 7-year period. Results Amongst 45 patients, 82.2% (37/45) had a pyogenic liver abscess (PLA) and 17.8% (8/45) had amoebic liver abscesses (ALA). Overall, patients were young (median age 42 years, IQR 35–52), mostly males (77.8%, 35/45) from the Indian subcontinent (55.6%, 25/45), presented with fever (88.9%, 40/45) and abdominal pain (88.9%, 40/45), and had a solitary abscess on imaging (71.1% (32/45). Crude annual incidence rates were 35.9/100,000 hospital admissions (95% CI 26.2–48.0) and 5.9/100,000 inhabitants (95% CI 4.3–7.9). All ALA patients were from the Indian subcontinent (100%, 8/8). Klebsiella pneumoniae was the most frequent pathogen in PLA (43.2% [16/37], 95% CI 27.1–60.5%). The hospital stay was shorter in ALA (7.5 days, IQR 7–8.5) than in PLA (14 days, IQR 9–17). No deaths were recorded within 30 days of hospitalisation. Conclusions ALA was exclusively seen in migrants from the Indian subcontinent, suggesting importation. Further research to characterise K. pneumoniae isolates and assess potential risk factors is needed.

scholarly journals Novel complication of an emerging disease: Invasive Klebsiella pneumoniae liver abscess syndrome as a cause of acute respiratory distress syndrome

2018 ◽  
Author(s):  
Anupam Gupta ◽  
Saad Bhatti ◽  
Anatoly Leytin ◽  
Oleg Epelbaum
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Klebsiella Pneumoniae ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Liver Abscess ◽  
English Language ◽  
Distress Syndrome ◽  
Pyogenic Liver Abscess ◽  
The Subject ◽  
Language Literature

Klebsiella pneumoniae is an increasingly recognized cause of a unique invasive syndrome manifesting as pyogenic liver abscess and hematogenous extrahepatic dissemination to a variety of sites, including the lung. Originally described only in Asia, this entity has now been reported across continents and ethnicities. Intrathoracic complications of invasive Klebsiella pneumoniae liver abscess syndrome (IKPLAS) have been characterized sporadically but have not been the subject of an all-encompassing investigation. Review of the English-language literature yields no reports of the acute respiratory distress syndrome as a consequence of IKPLAS. Herein we report what, to our knowledge, is the first such description.

Pyogenic liver abscess due to hypervirulent Klebsiella pneumoniae in a 14-year-old boy

2019 ◽  
Vol 25 (2) ◽  
pp. 137-140 ◽  
Author(s):  
Satoshi Sato ◽  
Tomohiro Aoyama ◽  
Yoji Uejima ◽  
Mihoko Furuichi ◽  
Eisuke Suganuma ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Liver Abscess ◽  
Pyogenic Liver Abscess

scholarly journals Pyogenic liver abscess caused by Klebsiella pneumoniae: analysis of the clinical characteristics and outcomes of 84 patients

2007 ◽  
Vol 120 (2) ◽  
pp. 136-139 ◽  
Author(s):  
Khee-siang CHAN ◽  
Wen-liang YU ◽  
Chi-lun TSAI ◽  
Kuo-chen CHENG ◽  
Ching-cheng HOU ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Liver Abscess ◽  
Clinical Characteristics ◽  
Pyogenic Liver Abscess

Successful hepatectomy for intraperitoneal rupture of pyogenic liver abscess caused by Klebsiella pneumoniae

2012 ◽  
Vol 5 (2) ◽  
pp. 136-140 ◽  
Author(s):  
Kazuhiko Morii ◽  
Asako Kashihara ◽  
Sho Miura ◽  
Hiroaki Okuhin ◽  
Takanori Watanabe ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Liver Abscess ◽  
Pyogenic Liver Abscess ◽  
Intraperitoneal Rupture

scholarly journals Humoral Immunity against Capsule Polysaccharide Protects the Host from magA+Klebsiella pneumoniae-Induced Lethal Disease by Evading Toll-Like Receptor 4 Signaling

2008 ◽  
Vol 77 (2) ◽  
pp. 615-621 ◽  
Author(s):  
Ming-Fang Wu ◽  
Chih-Ya Yang ◽  
Tzu-Lung Lin ◽  
Jin-Town Wang ◽  
Feng-Ling Yang ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Liver Abscess ◽  
Vaccine Development ◽  
Pyogenic Liver Abscess ◽  
Underlying Mechanism ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Mortality And Morbidity ◽  
Promising Target

ABSTRACT Klebsiella pneumoniae magA (for mucoviscosity-associated gene A) is linked to the pathogenesis of primary pyogenic liver abscess, but the underlying mechanism by which magA increases pathogenicity is not well elucidated. In this study, we investigated the role of the capsular polysaccharides (CPS) in the pathogenesis of magA + K. pneumoniae by comparing host immunity to magA + K. pneumoniae and a ΔmagA mutant. We found that Toll-like receptor 4 recognition by magA + K. pneumoniae was hampered by the mucoviscosity of the magA + K. pneumoniae CPS. Interestingly, monoclonal antibodies (MAbs) against magA + K. pneumoniae CPS recognized all of the K1 strains tested but not the ΔmagA and non-K1 strains. Moreover, the anti-CPS MAbs protected mice from magA + K. pneumoniae-induced liver abscess formation and lethality. This indicates that the K1 epitope is a promising target for vaccine development, and anti-CPS MAbs has great potential to protect host from K1 strain-induced mortality and morbidity in diabetic and other immunocompromised patients in the future.

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