Hendra Virus V Protein Inhibits Interferon Signaling by Preventing STAT1 and STAT2 Nuclear Accumulation
2003 ◽
Vol 77
(21)
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pp. 11842-11845
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Keyword(s):
ABSTRACT The V protein of the recently emerged paramyxovirus, Nipah virus, has been shown to inhibit interferon (IFN) signal transduction through cytoplasmic sequestration of cellular STAT1 and STAT2 in high-molecular-weight complexes. Here we demonstrate that the closely related Hendra virus V protein also inhibits cellular responses to IFN through binding and cytoplasmic sequestration of both STAT1 and STAT2, but not STAT3. These findings demonstrate a V protein-mediated IFN signal evasion mechanism that is a general property of the known Henipavirus species.
2004 ◽
Vol 78
(10)
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pp. 5358-5367
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Keyword(s):
1996 ◽
Vol 7
(8)
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pp. 1249-1258
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Keyword(s):
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2002 ◽
Vol 76
(22)
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pp. 11476-11483
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Keyword(s):
1990 ◽
Vol 48
(3)
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pp. 1-1
1993 ◽
Vol 70
(06)
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pp. 0978-0983
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