scholarly journals T-Cell Epitopes in Severe Acute Respiratory Syndrome (SARS) Coronavirus Spike Protein Elicit a Specific T-Cell Immune Response in Patients Who Recover from SARS

2004 ◽  
Vol 78 (14) ◽  
pp. 7861-7861 ◽  
Author(s):  
Yue-Dan Wang ◽  
Wan-Yee Fion Sin ◽  
Guo-Bing Xu ◽  
Huang-Hao Yang ◽  
Tin-yau Wong ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cell ◽  
Severe Acute Respiratory Syndrome ◽  
Spike Protein ◽  
Cell Immune Response ◽  
T Cell Epitopes ◽  
Sars Coronavirus

scholarly journals A PE Protein Expressed by Mycobacterium avium Is an Effective T-Cell Immunogen

2006 ◽  
Vol 74 (1) ◽  
pp. 786-789 ◽  
Author(s):  
Marcela Parra ◽  
Nathalie Cadieux ◽  
Thames Pickett ◽  
Veerabadran Dheenadhayalan ◽  
Michael J. Brennan
Keyword(s):  
Immune Response ◽  
Mycobacterium Tuberculosis ◽  
T Cell ◽  
Dna Vaccine ◽  
Mycobacterium Avium ◽  
Cell Immune Response ◽  
T Cell Epitopes

ABSTRACT Infection of mice with Mycobacterium avium or immunization with a novel PE gene expressed by M. avium (MaPE) showed that a dominant T-cell immune response was elicited. Immunization with an MaPE DNA vaccine protected mice against an aerosol challenge with Mycobacterium tuberculosis, suggesting that mycobacteria express PE antigens with cross-protective T-cell epitopes.

scholarly journals Understanding the T cell immune response in SARS coronavirus infection

2012 ◽  
Vol 1 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Hsueh-Ling Janice Oh ◽  
Samuel Ken-En Gan ◽  
Antonio Bertoletti ◽  
Yee-Joo Tan
Keyword(s):  
Immune Response ◽  
T Cell ◽  
Cell Immune Response ◽  
Sars Coronavirus ◽  
Coronavirus Infection

scholarly journals HLA-A∗0201 T-cell epitopes in severe acute respiratory syndrome (SARS) coronavirus nucleocapsid and spike proteins

2006 ◽  
Vol 344 (1) ◽  
pp. 63-71 ◽  
Author(s):  
Yeou-Ping Tsao ◽  
Jian-Yu Lin ◽  
Jia-Tsrong Jan ◽  
Chih-Hsiang Leng ◽  
Chen-Chung Chu ◽  
...  
Keyword(s):  
T Cell ◽  
Severe Acute Respiratory Syndrome ◽  
T Cell Epitopes ◽  
Sars Coronavirus ◽  
Spike Proteins

scholarly journals Publisher Correction: Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response

Nature Cancer ◽  
2021 ◽  
Author(s):  
Laura Poillet-Perez ◽  
Daniel W. Sharp ◽  
Yang Yang ◽  
Saurabh V. Laddha ◽  
Maria Ibrahim ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cell ◽  
Cell Immune Response ◽  
Mutational Burden

scholarly journals SARS-CoV-2 Human T cell Epitopes: adaptive immune response against COVID-19.

2021 ◽  
Author(s):  
Alba Grifoni ◽  
John Sidney ◽  
Randi Vita ◽  
Bjoern Peters ◽  
Shane Crotty ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cell ◽  
Adaptive Immune Response ◽  
T Cell Epitopes ◽  
Adaptive Immune ◽  
Human T Cell

scholarly journals Immunological imprinting of the antibody response in COVID-19 patients

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Teresa Aydillo ◽  
Alexander Rombauts ◽  
Daniel Stadlbauer ◽  
Sadaf Aslam ◽  
Gabriela Abelenda-Alonso ◽  
...  
Keyword(s):  
Immune Response ◽  
Severe Acute Respiratory Syndrome ◽  
Antibody Response ◽  
Humoral Immune Response ◽  
Nucleocapsid Protein ◽  
Spike Protein ◽  
Ongoing Research ◽  
Variable Regions ◽  
Humoral Immune ◽  
Human Coronaviruses

AbstractIn addition to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), humans are also susceptible to six other coronaviruses, for which consecutive exposures to antigenically related and divergent seasonal coronaviruses are frequent. Despite the prevalence of COVID-19 pandemic and ongoing research, the nature of the antibody response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unclear. Here we longitudinally profile the early humoral immune response against SARS-CoV-2 in hospitalized coronavirus disease 2019 (COVID-19) patients and quantify levels of pre-existing immunity to OC43, HKU1 and 229E seasonal coronaviruses, and find a strong back-boosting effect to conserved but not variable regions of OC43 and HKU1 betacoronaviruses spike protein. However, such antibody memory boost to human coronaviruses negatively correlates with the induction of IgG and IgM against SARS-CoV-2 spike and nucleocapsid protein. Our findings thus provide evidence of immunological imprinting by previous seasonal coronavirus infections that can potentially modulate the antibody profile to SARS-CoV-2 infection.

scholarly journals CD11chighCD8+ Regulatory T Cell Feedback Inhibits CD4 T Cell Immune Response via Fas Ligand–Fas Pathway

2013 ◽  
Vol 190 (12) ◽  
pp. 6145-6154 ◽  
Author(s):  
Zhubo Chen ◽  
Yanmei Han ◽  
Yan Gu ◽  
Yanfang Liu ◽  
Zhengping Jiang ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cell ◽  
Regulatory T Cell ◽  
Fas Ligand ◽  
Cd4 T Cell ◽  
Cell Immune Response ◽  
Fas Pathway
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