The c-myc-regulated gene mrl encodes plasminogen activator inhibitor 1.
1990 ◽
Vol 10
(3)
◽
pp. 1265-1269
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Keyword(s):
Pai 1
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The DNA sequence of the c-myc-regulated gene mrl (G. C. Prendergast and M. D. Cole, Mol. Cell. Biol. 9:124-134, 1989) reveals that it encodes plasminogen activator inhibitor 1 (PAI-1), a regulator of extracellular proteolysis. Comparison of the human and mouse PAI-1 promoters and cDNA 3' noncoding regions revealed several highly conserved sequence domains, potential targets for c-myc and other factors influencing PAI-1 expression. We discuss possible roles for PAI-1 in normal and neoplastic cell growth control.
1990 ◽
Vol 10
(3)
◽
pp. 1265-1269
2005 ◽
Vol 173
(4S)
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pp. 255-255
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1999 ◽
Vol 82
(07)
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pp. 104-108
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1988 ◽
Vol 59
(02)
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pp. 299-303
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1992 ◽
Vol 68
(05)
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pp. 486-494
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1994 ◽
Vol 72
(03)
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pp. 434-437
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1993 ◽
Vol 70
(02)
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pp. 301-306
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1995 ◽
Vol 73
(02)
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pp. 261-267
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1995 ◽
Vol 73
(05)
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pp. 829-834
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1993 ◽
Vol 268
(15)
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pp. 10739-10745