Increased secretion of type beta transforming growth factor accompanies viral transformation of cells

1985 ◽  
Vol 5 (1) ◽  
pp. 242-247
Author(s):  
M A Anzano ◽  
A B Roberts ◽  
J E De Larco ◽  
L M Wakefield ◽  
R K Assoian ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Growth Factor Receptor ◽  
Transformed Cells ◽  
Down Regulation ◽  
Untransformed Control ◽  
Transforming Growth Factor Receptor ◽  
Sarcoma Virus ◽  
Moloney Sarcoma Virus ◽  
Viral Transformation

Cells transformed by Harvey or Moloney sarcoma virus secrete at least 40 times as much type beta transforming growth factor as their respective untransformed control cells. The transformed cells bind only 20 to 50% as much type beta transforming growth factor as the control cells, suggesting that transformation causes down-regulation of the type beta transforming growth factor receptor.

scholarly journals Increased secretion of type beta transforming growth factor accompanies viral transformation of cells.

1985 ◽  
Vol 5 (1) ◽  
pp. 242-247 ◽  
Author(s):  
M A Anzano ◽  
A B Roberts ◽  
J E De Larco ◽  
L M Wakefield ◽  
R K Assoian ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Growth Factor Receptor ◽  
Transformed Cells ◽  
Down Regulation ◽  
Untransformed Control ◽  
Transforming Growth Factor Receptor ◽  
Sarcoma Virus ◽  
Moloney Sarcoma Virus ◽  
Viral Transformation

Cells transformed by Harvey or Moloney sarcoma virus secrete at least 40 times as much type beta transforming growth factor as their respective untransformed control cells. The transformed cells bind only 20 to 50% as much type beta transforming growth factor as the control cells, suggesting that transformation causes down-regulation of the type beta transforming growth factor receptor.

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