scholarly journals Dose-Dependent Relationship between Protection of Thioacetamide-Induced Acute Liver Injury and Hyperammonemia and Concentration of Lactobacillus salivarius Li01 in Mice

2021 ◽  
Vol 9 (3) ◽  
Author(s):  
Pengcheng Lou ◽  
Yangfan Shen ◽  
Aoxiang Zhuge ◽  
Longxian Lv ◽  
Xueling Zhu ◽  
...  
Keyword(s):  
Liver Injury ◽  
Acute Liver Injury ◽  
Lactobacillus Salivarius ◽  
Content Type ◽  
Dependent Relationship ◽  
The Relationship ◽  
Dose Dependent

This research investigated the relationship between the concentration of Lactobacillus salivarius Li01 and its impact on mice that had a thioacetamide-induced acute liver injury and hyperammonemia. These findings could provide new insights into the effective, proper, and safe use of probiotics.

scholarly journals Plasma paracetamol concentration at hospital presentation has a dose-dependent relationship with liver injury despite prompt treatment with intravenous acetylcysteine

2016 ◽  
Vol 54 (5) ◽  
pp. 405-410 ◽  
Author(s):  
David G. Cairney ◽  
Hannah K. S. Beckwith ◽  
Khalid Al-Hourani ◽  
Michael Eddleston ◽  
D. Nicholas Bateman ◽  
...  
Keyword(s):  
Liver Injury ◽  
Paracetamol Concentration ◽  
Prompt Treatment ◽  
Dependent Relationship ◽  
Dose Dependent

Lactobacillus salivarius LI01 encapsulated in alginate-pectin microgels ameliorates d-galactosamine-induced acute liver injury in rats

2020 ◽  
Vol 104 (17) ◽  
pp. 7437-7455
Author(s):  
Aoxiang Zhuge ◽  
Bo Li ◽  
Yin Yuan ◽  
Longxian Lv ◽  
Yating Li ◽  
...  
Keyword(s):  
Liver Injury ◽  
Acute Liver Injury ◽  
Lactobacillus Salivarius

scholarly journals Protective effect of Lactobacillus salivarius Li01 on thioacetamide‐induced acute liver injury and hyperammonaemia

2020 ◽  
Vol 13 (6) ◽  
pp. 1860-1876
Author(s):  
Liya Yang ◽  
Xiaoyuan Bian ◽  
Wenrui Wu ◽  
Longxian Lv ◽  
Yating Li ◽  
...  
Keyword(s):  
Liver Injury ◽  
Protective Effect ◽  
Acute Liver Injury ◽  
Lactobacillus Salivarius

scholarly journals Dental Amalgams and the Incidence Rate of Arthritis among American Adults

2021 ◽  
Vol 14 ◽  
pp. 117954412110162
Author(s):  
David A Geier ◽  
Mark R Geier
Keyword(s):  
The United States ◽  
Dental Amalgam ◽  
Exposed Group ◽  
Unexposed Group ◽  
Dependent Relationship ◽  
Dental Amalgams ◽  
Annual Total ◽  
The Relationship ◽  
Dose Dependent ◽  
Annual Total Cost

This hypothesis-testing study evaluated the relationship between mercury (Hg)-based dental amalgams and arthritis diagnoses among adults in the United States (US). A total of 86 305 425 weighted-persons with ⩾1 dental amalgam filling surface (DAFS) (exposed group) and 32 201 088 weighted-persons with ⩾1 other dental filling surface (ODFS) (no DAFS, unexposed group) were examined in the 2015 to 2016 National Health and Nutritional Examination Survey (NHANES). All persons were 20 to 80 years-old with known demographic characteristics and arthritis status. Survey logistic regression and survey frequency modeling in SAS were employed with and without adjustment of covariates. The arthritis rate was significantly increased in the exposed group compared to the unexposed group in the unadjusted (7.68-fold) and adjusted (4.89-fold) models. Arthritis (per 10 000 weighted-person-years) was 6.0-fold significantly increased in the exposed group (6.2) compared to the unexposed group (1.06). A significant bimodal dose-dependent relationship between DAFS and arthritis rate was observed. The arthritis rate increased with increasing DAFS (peak among persons with 4-7 DAFS) and, subsequently, decreased among those with >6 DAFS. A significant decrease in arthritis rate among persons with >13 DAFS as compared to those persons with 4 to 7 DAFS was observed. A significant association between DAFS and arthritis risk and a dose-dependent DAFS associated immune-stimulation/immune-suppression with arthritis risk were observed. An estimated additional $96 835 814 US dollars (USD) are spent on annual medical costs and $184 797 680 USD are lost in annual wages from reported new onset arthritis attributably associated with DAFS (annual total cost = $281 633 494 USD).

Nicotinamide improves NAD+ levels to protect against acetaminophen-induced acute liver injury in mice

2021 ◽  
pp. 096032712110145
Author(s):  
J Xu ◽  
L Zhang ◽  
R Jiang ◽  
K Hu ◽  
D Hu ◽  
...  
Keyword(s):  
Liver Injury ◽  
Acute Liver Injury ◽  
Related Factor ◽  
Dependent Manner ◽  
Nicotinamide Phosphoribosyltransferase ◽  
Apap Overdose ◽  
Hepatoprotective Effects ◽  
Dose Dependent ◽  
Different Doses

Acetaminophen (APAP) overdose causes acute liver injury (ALI). Nicotinamide adenine dinucleotide (NAD) is an essential coenzyme, and NAD+ is oxidized type which synthesized from nicotinamide (NAM). The present study aimed to investigate the role of NAD+ in ALI and protective property of NAM. The mice were subjected to different doses APAP. After 8 hours, the serum activities of alaninetransaminase (ALT) and aspartate aminotransferase (AST), the hepatic NAD+ level and nicotinamide phosphoribosyltransferase (NAMPT) expression were determined. Then, the mice were pretreated with NAM (800 mg/kg), the hepatoprotective effects and the key antioxidative molecules were evaluated. Our findings indicated that APAP resulted in remarkable NAD+ depletion in a dose-dependent manner accompanied by NAMPT downregulation, and NAM pretreatment significantly elevated the NAD+ decline due to upregulation of NAMPT. Moreover, the downregulated Kelch-like ECH-associated protein-1 (Keap1), upregulated nuclear factor erythroid 2-related factor 2 (Nrf2) and its translocation activation after NAM administration were confirmed, which were in accordance with improved superoxide dismutase (SOD) and glutathione (GSH) levels. Finally, NAM dramatically exhibited hepatoprotective effects by reducing the liver index and necrotic area. This study has suggested that APAP impairs liver NAD+ level and NAM is able to improve hepatic NAD+ to activate antioxidant pathway against APAP-induced ALI.

scholarly journals Draft Genome Sequence of Aryl Hydrocarbon Receptor Activator Strains Lactobacillus reuteri R2lc and 2010

2019 ◽  
Vol 8 (14) ◽  
Author(s):  
Mustafa Özçam ◽  
Jan-Peter van Pijkeren
Keyword(s):  
Liver Injury ◽  
Lactobacillus Reuteri ◽  
Acute Liver Injury ◽  
Draft Genome ◽  
Disease Models ◽  
Animal Disease ◽  
Content Type ◽  
Aryl Hydrocarbon ◽  
Animal Disease Models ◽  
Receptor Activator

Lactobacillus reuteri R2lc and 2010 are pigmented rat intestinal isolates. L. reuteri R2lc has been studied in different animal disease models, including colitis and acute liver injury.

scholarly journals Rutaecarpine Protects against Acetaminophen-Induced Acute Liver Injury in Mice by Activating Antioxidant Enzymes

Antioxidants ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 86
Author(s):  
Jae Ho Choi ◽  
Sun Woo Jin ◽  
Gi Ho Lee ◽  
Eun Hee Han ◽  
Yong Pil Hwang ◽  
...  
Keyword(s):  
Antioxidant Enzymes ◽  
Liver Injury ◽  
Protective Effect ◽  
Acute Liver Injury ◽  
Glutathione Depletion ◽  
Dependent Manner ◽  
Evodia Rutaecarpa ◽  
Malondialdehyde Content ◽  
Cyp2e1 Expression ◽  
Dose Dependent

Rutaecarpine, an indolopyridoquinazolinone alkaloid isolated from the unripe fruit of Evodia rutaecarpa, is used to treat hypertension, postpartum hemorrhage, dysentery, and amenorrhea as a traditional medicine in Asia. We investigated the effect of rutaecarpine on acetaminophen-induced hepatotoxicity in mice. Rutaecarpine was administered orally daily for seven consecutive days, followed by intraperitoneal injection of acetaminophen in mice on day seven to induce hepatotoxicity. Rutaecarpine pretreatment significantly decreased acetaminophen-induced serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) activities and hepatic malondialdehyde content and prevented acetaminophen-induced hepatic glutathione depletion. Furthermore, CYP2E1 expression was decreased by rutaecarpine pretreatment in a dose-dependent manner. Rutaecarpine pretreatment inhibited acetaminophen-induced expression of inflammatory cytokines by inhibiting NF-κB activation by JNK1/2. Also, rutaecarpine pretreatment promoted Nrf2-mediated activation of the antioxidant enzymes GCLC, HO-1, and NQO1. This indicates that the protective effect of rutaecarpine during acetaminophen-induced acute liver injury is mediated by the activation of antioxidant enzymes. Therefore, rutaecarpine has a protective effect of APAP-induced liver damage.

scholarly journals The correlation between IL-33 and inflammation factors in rheumatoid arthritis patients in vivo and in fibroblast-like synoviocytes in vitro

2020 ◽  
Author(s):  
Jing Wu ◽  
Qiang Li ◽  
Jia-Xin Deng ◽  
Jin-Jun Zhao ◽  
Qing-Hong Yu
Keyword(s):  
Rheumatoid Arthritis ◽  
Synovial Fluid ◽  
Interleukin 33 ◽  
Cytokines And Chemokines ◽  
Dependent Relationship ◽  
The Relationship ◽  
Dose Dependent ◽  
Fibroblast Like Synoviocytes

Abstract Background: Interleukin-33 (IL-33) is a member of the IL-1 family of cytokines whose role remains controversial in rheumatoid arthritis (RA), because no clear conclusion has been established regarding the relationship between IL-33 and other cytokines and chemokines. The present study was conducted to evaluate the correlation of IL-33 with other cytokines and chemokines in serum and the synovia, and to explore the nature of the relationship.Results: IL-33 was found to exhibit an inverted-U-shaped correlation with multiple cytokines and chemokines in synovial fluid, including IL-6, IL-1β, CXCL8 (IL-8), CXCL9 (MIG) and CXCL10 (IP-10), but not in serum. Moreover, in vitro experiments confirmed that IL-33 also exhibits U-type dose-dependent regulation of FLS function.Conclusions: IL-33 exhibit an inverted-U-shaped correlation with multiple cytokines and chemokines in synovial fluid of RA patients. IL-33 affects the secretion of cytokines and chemokines in the synovium in a U-type dose-dependent relationship.

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