Development of bacteriochlorophyll a-based near-infrared photosensitizers conjugated to gold nanoparticles for photodynamic therapy of cancer

Theories of radiationless conversions and of chemical processes were employed to design better photosensitizers for photodynamic therapy (PDT). In addition to photostability and intense absorption in the near infrared, these photosensitizers were required to generate high yields of long-lived triplet states that could efficiently transfer their energy, or an electron, to molecular oxygen. The guidance provided by the theories was combined with the ability to synthesize large quantities of pure photosensitizers and with the biological screening of graded hydrophilicities/lipophilicities. The theoretical prediction that halogenated sulfonamide tetraphenylbacteriochlorins could satisfy all the criteria for ideal PDT photosensitizers was verified experimentally.

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Atom transfer radical-polymerized cationic shells on gold nanoparticles for near infrared-triggered photodynamic therapy of tumor-bearing animals

Journal of Materials Chemistry B ◽

10.1039/d1tb02004h ◽

2021 ◽

Author(s):

Oanh-Vu Pham-Nguyen ◽

Ju Won Lee ◽

Sila Jin ◽

Yeonju Park ◽

Song Rae Kim ◽

...

Keyword(s):

Gold Nanoparticles ◽

Photodynamic Therapy ◽

Near Infrared ◽

Atom Transfer ◽

Ethyl Methacrylate ◽

Tumor Bearing

Gold nanoparticles (AuNPs) were surface-engineered with a cationic corona to enhance the incorporation of photosensitizers for photodynamic therapy. The cationic corona composed of poly(2-(dimethylamino)ethyl methacrylate) was atom transfer radical-polymerized on...

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Fabrication of red blood cell membrane-camouflaged Cu2−xSe nanoparticles for phototherapy in the second near-infrared window

Chemical Communications ◽

10.1039/c9cc03148k ◽

2019 ◽

Vol 55 (46) ◽

pp. 6523-6526 ◽

Cited By ~ 6

Author(s):

Zhou Liu ◽

Jinquan Wang ◽

Kangqiang Qiu ◽

Xinxing Liao ◽

Thomas W. Rees ◽

...

Keyword(s):

Photodynamic Therapy ◽

Cell Membrane ◽

Blood Cell ◽

Red Blood Cell ◽

Near Infrared ◽

Red Blood Cell Membrane ◽

Photodynamic Therapy Of Cancer ◽

Se Nanoparticles ◽

Infrared Window

Cu2−xSe nanoparticles (Cu2−xSeNPs) were camouflaged with a red blood cell membrane (RBC) for synergistic photothermal and photodynamic therapy of cancer in the second near-infrared (NIR II) window.

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5-aminolevulinic acid-conjugated gold nanoparticles for photodynamic therapy of cancer

Nanomedicine ◽

10.2217/17435889.3.6.777 ◽

2008 ◽

Vol 3 (6) ◽

pp. 777-786 ◽

Cited By ~ 63

Author(s):

Maung Kyaw Khaing Oo ◽

Xiaochuan Yang ◽

Henry Du ◽

Hongjun Wang

Keyword(s):

Gold Nanoparticles ◽

Photodynamic Therapy ◽

Aminolevulinic Acid ◽

Photodynamic Therapy Of Cancer

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Role of 5-aminolevulinic acid-conjugated gold nanoparticles for photodynamic therapy of cancer

Journal of Biomedical Optics ◽

10.1117/1.jbo.20.5.051043 ◽

2015 ◽

Vol 20 (5) ◽

pp. 051043 ◽

Cited By ~ 28

Author(s):

Zhenxi Zhang ◽

Sijia Wang ◽

Hao Xu ◽

Bo Wang ◽

Cuiping Yao

Keyword(s):

Gold Nanoparticles ◽

Photodynamic Therapy ◽

Aminolevulinic Acid ◽

Photodynamic Therapy Of Cancer

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Photosensitiser-gold nanoparticle conjugates for photodynamic therapy of cancer

Photochemical & Photobiological Sciences ◽

10.1039/c8pp00271a ◽

2018 ◽

Vol 17 (11) ◽

pp. 1534-1552 ◽

Cited By ~ 25

Author(s):

Paula García Calavia ◽

Gordon Bruce ◽

Lluïsa Pérez-García ◽

David A. Russell

Keyword(s):

Gold Nanoparticles ◽

Photodynamic Therapy ◽

Cancer Therapy ◽

Gold Nanoparticle ◽

State Of The Art ◽

The State ◽

Photodynamic Therapy Of Cancer ◽

Photodynamic Cancer Therapy

A review describing the state-of-the-art of the functionalisation of gold nanoparticles with photosensitisers and targeting ligands for photodynamic cancer therapy.

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