5-aminolevulinic acid-conjugated gold nanoparticles for photodynamic therapy of cancer

Nanomedicine ◽  
2008 ◽  
Vol 3 (6) ◽  
pp. 777-786 ◽  
Author(s):  
Maung Kyaw Khaing Oo ◽  
Xiaochuan Yang ◽  
Henry Du ◽  
Hongjun Wang
Keyword(s):  
Gold Nanoparticles ◽  
Photodynamic Therapy ◽  
Aminolevulinic Acid ◽  
Photodynamic Therapy Of Cancer

Role of 5-aminolevulinic acid-conjugated gold nanoparticles for photodynamic therapy of cancer

2015 ◽  
Vol 20 (5) ◽  
pp. 051043 ◽  
Author(s):  
Zhenxi Zhang ◽  
Sijia Wang ◽  
Hao Xu ◽  
Bo Wang ◽  
Cuiping Yao
Keyword(s):  
Gold Nanoparticles ◽  
Photodynamic Therapy ◽  
Aminolevulinic Acid ◽  
Photodynamic Therapy Of Cancer

Cooperative Effect of 5-Aminolevulinic Acid and Gold Nanoparticles for Photodynamic Therapy of Cancer

2013 ◽  
Vol 102 (8) ◽  
pp. 2760-2769 ◽  
Author(s):  
Marta Benito ◽  
Virginia Martín ◽  
María Dolores Blanco ◽  
Jose M. Teijón ◽  
Clara Gómez
Keyword(s):  
Gold Nanoparticles ◽  
Photodynamic Therapy ◽  
Aminolevulinic Acid ◽  
Cooperative Effect ◽  
Photodynamic Therapy Of Cancer

Development of bacteriochlorophyll a-based near-infrared photosensitizers conjugated to gold nanoparticles for photodynamic therapy of cancer

2015 ◽  
Vol 80 (6) ◽  
pp. 752-762 ◽  
Author(s):  
I. V. Pantiushenko ◽  
P. G. Rudakovskaya ◽  
A. V. Starovoytova ◽  
A. A. Mikhaylovskaya ◽  
M. A. Abakumov ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Photodynamic Therapy ◽  
Near Infrared ◽  
Bacteriochlorophyll A ◽  
Photodynamic Therapy Of Cancer

scholarly journals Photosensitiser-gold nanoparticle conjugates for photodynamic therapy of cancer

2018 ◽  
Vol 17 (11) ◽  
pp. 1534-1552 ◽  
Author(s):  
Paula García Calavia ◽  
Gordon Bruce ◽  
Lluïsa Pérez-García ◽  
David A. Russell
Keyword(s):  
Gold Nanoparticles ◽  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Gold Nanoparticle ◽  
State Of The Art ◽  
The State ◽  
Photodynamic Therapy Of Cancer ◽  
Photodynamic Cancer Therapy

A review describing the state-of-the-art of the functionalisation of gold nanoparticles with photosensitisers and targeting ligands for photodynamic cancer therapy.

Glycoside Esters of 5-Aminolevulinic Acid for Photodynamic Therapy of Cancer

2008 ◽  
Vol 19 (4) ◽  
pp. 821-839 ◽  
Author(s):  
Ramakrishnan Vallinayagam ◽  
Frédéric Schmitt ◽  
Jérome Barge ◽  
Georges Wagnieres ◽  
Virginie Wenger ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Aminolevulinic Acid ◽  
Photodynamic Therapy Of Cancer

scholarly journals Reactivation of TAp73 tumor suppressor by protoporphyrin IX, a metabolite of aminolevulinic acid, induces apoptosis in TP53-deficient cancer cells

2018 ◽  
Author(s):  
Alicja Sznarkowska ◽  
Anna Kostecka ◽  
Anna Kawiak ◽  
Pilar Acedo ◽  
Mattia Lion ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Clinical Practice ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Ubiquitin Ligase ◽  
Aminolevulinic Acid ◽  
Protoporphyrin Ix ◽  
Drug Repurposing ◽  
Functional Similarity ◽  
Photodynamic Therapy Of Cancer

AbstractBackgroundThe p73 protein is a tumor suppressor that shares structural and functional similarity with p53. p73 is expressed in two major isoforms; the TA isoform that interacts with p53 pathway, thus acting as tumor suppressor and the N-terminal truncated ΔN isoform that inhibits TAp73 and p53 and thus, acts as an oncogene.ResultsBy employing a drug repurposing approach, we found that protoporphyrin IX (PpIX), a metabolite of aminolevulinic acid (ALA) applied in photodynamic therapy of cancer, stabilizes TAp73 and activates TAp73-dependent apoptosis in cancer cells lacking p53. The mechanism of TAp73 activation is via disruption of TAp73/MDM2 and TAp73/MDMX interactions and inhibition of TAp73 degradation by ubiquitin ligase Itch.ConclusionOur findings may in future contribute to the successful repurposing of PpIX into clinical practice.

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