Morphogenesis and reaction to hypoxia of atrial myoendocrine cells in chick embryos (Gallus gallus)

2013 ◽  
Vol 49 (2) ◽  
pp. 251-258 ◽  
Author(s):  
V. F. Maksimov ◽  
I. M. Korostyshevskaya
Keyword(s):  
Gallus Gallus ◽  
Chick Embryos ◽  
Myoendocrine Cells

scholarly journals Okadaic acid exposure induced neural tube defects in chicken (Gallus gallus) embryos

2020 ◽  
Author(s):  
Yu-hu Jiao ◽  
Guang Wang ◽  
Da-wei Li ◽  
Hong-ye Li ◽  
Jie-sheng Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Proliferation ◽  
Signaling Pathway ◽  
Okadaic Acid ◽  
Neural Tube ◽  
Gallus Gallus ◽  
Chick Embryos ◽  
Receptor Signaling ◽  
Toll Like Receptor ◽  
Receptor Signaling Pathway

Abstract Background Okadaic acid (OA) is an important liposoluble shellfish toxin distributed worldwide, and mainly responsible for diarrheic shellfish poisoning (DSP) in human beings. It has a variety of toxicities, including cytotoxicity, embryonic toxicity, neurotoxicity, and even genotoxicity. The embryotoxicity of OA is due to it can cross the placental barrier, which was proven in mice. However, there is no direct evidence of its developmental toxicity in human offspring. The chicken (Gallus gallus) embryo is a classic animal model for the studies of early vertebrate embryogenesis and late organogenesis due to its multiple advantages, such as convenience for observation, similarity to mammalian embryo, easy accessibility, and manipulation, etc. Results OA exposure could cause NTDs and inhibit the neuronal differentiation. Immunofluorescent staining demonstrated that OA exposure promoted cell proliferation and inhibit cell apoptosis on the developing neural tube. Besides, the down-regulation of Nrf2 and increases in ROS content and SOD activity in the OA-exposed chicken embryos indicated that OA could result in the generation of oxidative stress in early chick embryos. The inhibition of BMP4 and Shh expression in the dorsal neural tube suggested that OA could also affect the formation of dorsolateral hinge points. The expression of LBP, JUN, FOS, and CCL4 in Toll-like receptor signaling pathway was significantly increased in the OA-exposed embryos, suggesting that the NTDs induced by OA might be associated with Toll-like receptor signaling pathway. Conclusion OA exposure can induce NTDs in chick embryos and increase the incidences of embryo mortality and malformation. Oxidative stress in early chick embryos may be subsequently responsible for the formation of NTDs. OA exposure can affect cell proliferation and apoptosis. Toll-like receptor signaling pathway may be responsible for the NTDs induced by OA.

scholarly journals Towards Tabula Gallus

2022 ◽  
Vol 23 (2) ◽  
pp. 613
Author(s):  
Masahito Yamagata
Keyword(s):  
Developmental Biology ◽  
Molecular Biology ◽  
Human Cell ◽  
Cell Biology ◽  
Gallus Gallus ◽  
Chick Embryos ◽  
Transcriptome Data ◽  
Cell Type ◽  
Cell Transcriptome ◽  
Single Cell Transcriptome

The Tabula Gallus is a proposed project that aims to create a map of every cell type in the chicken body and chick embryos. Chickens (Gallus gallus) are one of the most recognized model animals that recapitulate the development and physiology of mammals. The Tabula Gallus will generate a compendium of single-cell transcriptome data from Gallus gallus, characterize each cell type, and provide tools for the study of the biology of this species, similar to other ongoing cell atlas projects (Tabula Muris and Tabula Sapiens/Human Cell Atlas for mice and humans, respectively). The Tabula Gallus will potentially become an international collaboration between many researchers. This project will be useful for the basic scientific study of Gallus gallus and other birds (e.g., cell biology, molecular biology, developmental biology, neuroscience, physiology, oncology, virology, behavior, ecology, and evolution). It will eventually be beneficial for a better understanding of human health and diseases.

scholarly journals Cadmium affects the development of somites in chick embryos ( Gallus gallus domesticus ) under in vitro conditions

2018 ◽  
Vol 42 (4) ◽  
pp. 359-365 ◽  
Author(s):  
Samira KAZEMI ◽  
Naser MAHDAVI-SHAHRI ◽  
Roya LARI ◽  
Fatemeh Behnam RASSOULI
Keyword(s):  
Gallus Gallus ◽  
Gallus Domesticus ◽  
Chick Embryos ◽  
Gallus Gallus Domesticus

scholarly journals The effects of lead on the development of somites in chick embryos (Gallus gallus domesticus) under in vitro conditions: a histological study

2019 ◽  
Vol 8 (3) ◽  
pp. 373-380 ◽  
Author(s):  
Zahra Amini ◽  
Naser Mahdavi-Shahri ◽  
Roya Lari ◽  
Fatemeh Behnam Rassouli
Keyword(s):  
Toxic Metals ◽  
Histological Study ◽  
Gallus Gallus ◽  
Gallus Domesticus ◽  
Chick Embryos ◽  
Gallus Gallus Domesticus ◽  
Harmful Effects

Lead (Pb) is one of the most abundant toxic metals in the environment that can cause a variety of harmful effects.

Teratological Effect of Indoxacarb on Chick Embryos (Gallus gallus domesticus)

2019 ◽  
Author(s):  
Safeer Abbas ◽  
Razia Iqbal ◽  
Sumbal Haleem ◽  
Sadaf Niaz ◽  
Riaz Ullah ◽  
...  
Keyword(s):  
Gallus Gallus ◽  
Gallus Domesticus ◽  
Control Group ◽  
Chick Embryos ◽  
Gallus Gallus Domesticus ◽  
Crown Rump Length ◽  
Body Coloration ◽  
Dose Concentration ◽  
Eye Diameter ◽  
Beak Length

The present study was designed to assess the teratological effects of Indoxacarb on chick embryos (Gallus gallus domesticus) by administering different doses of commercial Indoxacarb (0.5, 1.0 and 1.5ml/1000ml/egg, in three experimental groups B, C and D) injected into the yolk sac of eggs before incubation. Embryos were recovered at day 12 of incubation. The mortality rate gradually increased from lower to higher doses. A total of twelve morphometric parameters viz., wet body weight, crown rump length, anterior posterior head diameter, eye diameter, beak length, neck length, humerus length, radius and ulna length, metacarpus length, femur length, fibula length and metatarsus length were recorded and compared with control group. These quantitative parameters indicated significant plessthan0.05) decrease in all treated groups compared to control group. While the qualitative anomalies such as microcephaly, hydrocephaly, edematous swelling, hematoma formation, abnormal body coloration, anophthalmia, microphthalmia, deformed beak, agnathia, wry neck, micromelia, amelia, omphalocele and ectopia cardis were also recorded in treated groups as compared to untreated groups. Therefore, it is concluded that Indoxacarb has potentially harmful effects on the development of avian embryos even at very low dose concentration. Hence, due to toxicity of this pesticide it must be used with utmost caution.

Teratogenic Effects of Chlorantraniliprole on chick embryos (Gallus gallus domesticus)

2017 ◽  
Author(s):  
Safeer Abbas ◽  
Razia Iqbal ◽  
Muhammad Zeeshan Butt ◽  
Sadaf Niaz ◽  
Sumbal Haleem ◽  
...  
Keyword(s):  
Gallus Gallus ◽  
Gallus Domesticus ◽  
Control Group ◽  
Chick Embryos ◽  
Gallus Gallus Domesticus ◽  
Teratogenic Effects ◽  
Crown Rump Length ◽  
Body Coloration ◽  
Dose Concentration ◽  
Beak Length

The present study was designed to assess the teratogenic effects of Chlorantraniliprole on chick embryos (Gallus gallus domesticus). Different doses of commercial Chlorantraniliprole (0.1, 0.5, 1.0 and 1.5µl/1000µl/egg, in four experimental groups B, C, D, and E respectively) were injected into the yolk sac of eggs before incubation. Embryos were recovered at day 12 of incubation. The mortality rate gradually increased from lower to higher doses. A total of twelve morphometric parameters viz., wet body weight, crown rump length, anterior posterior head diameter, eye diameter, beak length, neck length, humor length, radius and ulna length, metacarpus length, femur length, fibula length and metatarsus length were recorded and compared with control group. These quantitative parameters indicated significant (p>0.05) decreases in all treated groups compared to control group. While the qualitative anomalies such as microcephaly, hydrocephaly, edematous swelling, hematoma formation, abnormal body coloration, microphthalmia, deformed beak, agnathia, micromelia, amelia, omphalocele and ectopia cardis were also observed in treated groups as compared to untreated groups. Therefore it is concluded that Chlorantraniliprole has potentially harmful effects on the development of avian embryos even at very low dose concentration. Hence, due to toxicity of this pesticide it can be used with utmost caution.

Teratogenic effects of the neonicotinoid thiacloprid on chick embryos (Gallus gallus domesticus)

2018 ◽  
Vol 118 ◽  
pp. 812-820 ◽  
Author(s):  
Antonio Salvaggio ◽  
Francesco Antoci ◽  
Antonino Messina ◽  
Margherita Ferrante ◽  
Chiara Copat ◽  
...  
Keyword(s):  
Gallus Gallus ◽  
Gallus Domesticus ◽  
Chick Embryos ◽  
Gallus Gallus Domesticus ◽  
Teratogenic Effects

scholarly journals TGFβ signaling is required for sclerotome resegmentation during development of the spinal column in Gallus gallus.

2021 ◽  
Author(s):  
Sade W Clayton ◽  
Ronisha McCardell ◽  
Rosa Serra
Keyword(s):  
Direct Evidence ◽  
Spinal Column ◽  
Axial Skeleton ◽  
Gallus Gallus ◽  
Intervertebral Discs ◽  
Lineage Tracing ◽  
Chick Embryos ◽  
Fluorescent Tracers ◽  
Tgfβ Signaling

We previously showed the importance of TGFβ signaling in development of the mouse axial skeleton. Here, we provide the first direct evidence that TGFβ signaling is required for resegmentation of the sclerotome using chick embryos. Lipophilic fluorescent tracers, DiO and DiD, were microinjected into adjacent somites of embryos treated with or without TGFβR1 inhibitor, SB431542, at developmental day E2.5 (HH16). Lineage tracing of labeled cells was observed over the course of 4 days until the completion of resegmentation at E6.5 (HH32). Vertebrae were malformed and intervertebral discs were small and misshapen in SB431542 injected embryos. Inhibition of TGFβ signaling resulted in alterations in resegmentation that ranged between full, partial, and slanted shifts in distribution of DiO or DiD labeled cells within vertebrae. Patterning of rostro- caudal markers within sclerotome was disrupted at E3.5 after treatment with SB431542 with rostral domains expressing both rostral and caudal markers. Hypaxial myofibers were also increased in thickness after treatment with the inhibitor. We propose that TGFβ signaling regulates rostro-caudal polarity and subsequent resegmentation in sclerotome during spinal column development.

Dexamethasone Effect on Embryonic Chick Respiratory Epithelium

1982 ◽  
Vol 40 ◽  
pp. 248-249
Author(s):  
M.R. Richter ◽  
R.V. Blystone
Keyword(s):  
Lung Development ◽  
Critical Role ◽  
Respiratory Epithelium ◽  
Chick Embryos ◽  
Embryonic Chick ◽  
White Leghorn ◽  
Lung Maturation ◽  
Synthetic Analogs ◽  
Lung Physiology ◽  
Avian Lung

Dexamethasone and other synthetic analogs of corticosteroids have been employed clinically as enhancers of lung development. The mechanism(s) by which this steroid induction of later lung maturation operates is not clear. This study reports the effect on lung epithelia of dexamethasone administered at different intervals during development. White Leghorn chick embryos were used so as to remove possible maternal and placental influences on the exogenously applied steroid. Avian lung architecture does vary from mammals; however, respiratory surfactant produced by the lung epithelia serves an equally critical role in avian lung physiology.

Development of the Foramen Secundum in the Chick as Observed by Scanning Electron Microscopy

1976 ◽  
Vol 34 ◽  
pp. 212-213
Author(s):  
M.J.C. Hendrix ◽  
D.E. Morse
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Procaine Hydrochloride ◽  
Cardiac Anomaly ◽  
Chick Embryos ◽  
Congenital Cardiac Anomaly ◽  
Septal Defects ◽  
Critical Point Drying ◽  
Scanning Electron

Atrial septal defects are considered the most common congenital cardiac anomaly occurring in humans. In studying the normal sequential development of the atrial septum, chick embryos of the White Leghorn strain were prepared for scanning electron microscopy and the results were then extrapolated to the human heart. One-hundred-eighty chick embryos from 2 to 21 days of age were removed from their shells and immersed in cold cacodylate-buffered aldehyde fixative . Twenty-four embryos through the first week post-hatching were perfused in vivo using cold cacodylate-buffered aldehyde fixative with procaine hydrochloride. The hearts were immediately dissected free and remained in the fixative a minimum of 2 hours. In most cases, the lateral atrial walls were removed during this period. The tissues were then dehydrated using a series of ascending grades of ethanol; final dehydration of the tissues was achieved via the critical point drying method followed by sputter-coating with goldpalladium.

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