A new method for loading mesoporous silica nanoparticles with drugs: Sol–gel synthesis using drug micelles as a template

2016 ◽  
Vol 78 (5) ◽  
pp. 586-595 ◽  
Author(s):  
O. V. Dement’eva ◽  
I. N. Senchikhin ◽  
M. E. Kartseva ◽  
V. A. Ogarev ◽  
A. V. Zaitseva ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Sol Gel ◽  
New Method ◽  
Sol Gel Synthesis

scholarly journals Large Pore Mesoporous Silica and Organosilica Nanoparticles for Pepstatin A Delivery in Breast Cancer Cells

Molecules ◽  
2019 ◽  
Vol 24 (2) ◽  
pp. 332 ◽  
Author(s):  
Saher Rahmani ◽  
Jelena Budimir ◽  
Mylene Sejalon ◽  
Morgane Daurat ◽  
Dina Aggad ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Cathepsin D ◽  
Breast Cancer Cells ◽  
Potent Inhibitor ◽  
Mesoporous Silica Nanoparticles ◽  
Sol Gel ◽  
Pepstatin A

(1) Background: Nanomedicine has recently emerged as a new area of research, particularly to fight cancer. In this field, we were interested in the vectorization of pepstatin A, a peptide which does not cross cell membranes, but which is a potent inhibitor of cathepsin D, an aspartic protease particularly overexpressed in breast cancer. (2) Methods: We studied two kinds of nanoparticles. For pepstatin A delivery, mesoporous silica nanoparticles with large pores (LPMSNs) and hollow organosilica nanoparticles (HOSNPs) obtained through the sol–gel procedure were used. The nanoparticles were loaded with pepstatin A, and then the nanoparticles were incubated with cancer cells. (3) Results: LPMSNs were monodisperse with 100 nm diameter. HOSNPs were more polydisperse with diameters below 100 nm. Good loading capacities were obtained for both types of nanoparticles. The nanoparticles were endocytosed in cancer cells, and HOSNPs led to the best results for cancer cell killing. (4) Conclusions: Mesoporous silica-based nanoparticles with large pores or cavities are promising for nanomedicine applications with peptides.

scholarly journals Macrophage-like THP-1 cells show effective uptake of silica nanoparticles carrying inactivated diphtheria toxoid for vaccination

2020 ◽  
Vol 22 (1) ◽  
Author(s):  
Xinyue Huang ◽  
Danielle Paixão Cavalcante ◽  
Helen E Townley
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Sol Gel ◽  
Porous Silica ◽  
Diphtheria Toxoid ◽  
Similar Distribution ◽  
Antigen Delivery ◽  
Before And After ◽  
Post Synthesis

AbstractNanoparticles may be used in vaccinology as an antigen delivery and/or an immunostimulant to enhance immunity. Porous silica has been identified as an effective adjuvant for more than a decade, and we have therefore investigated the take up rate by an immortalized macrophage-like cell line of a number of mesoporous silica nanoparticles (MSNPs) with differing diameter and pore size. The MSNPs were synthesized using a sol-gel reaction and post-synthesis removal of the template. The MSNPs showed a clear distribution in take up rate peaking at 217 nm, whereas a comparison with solid spherical nanoparticles showed a similar distribution peaking at 377 nm. The MSNPs were investigated before and after loading with antigen. Diphtheria toxoid was used as a proof-of-concept antigen and showed a peak macrophage internalization of 53.42% for loaded LP3 particles which had a diameter of 217.75 ± 5.44 nm and large 16.5 nm pores. Optimal MSNP sizes appeared to be in the 200–400 nm range, and larger pores showed better antigen loading. The mesoporous silica particles were shown to be generally biocompatible, and cell viability was not altered by the loading of particles with or without antigen.

Fabrication of mesoporous silica nanoparticles by sol gel method followed various hydrothermal temperature

2018 ◽  
Author(s):  
Hariyati Purwaningsih ◽  
Vania Mitha Pratiwi ◽  
Siti Annisa Bani Purwana ◽  
Haniffudin Nurdiansyah ◽  
Yenny Rahmawati ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Sol Gel ◽  
Hydrothermal Temperature ◽  
Gel Method ◽  
Sol Gel Method

Preparation of Mesoporous Silica Nanoparticles Modified by Urushiol and Their Adsorption on Malachite Green

2021 ◽  
Vol 21 (9) ◽  
pp. 4792-4796
Author(s):  
Xue-Qing Xiao ◽  
Zhi-Yu Chen ◽  
Jia-Wen Chen ◽  
Qin-Hui Chen
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Malachite Green ◽  
Negative Impact ◽  
Mesoporous Silica Nanoparticles ◽  
Sol Gel ◽  
Dye Adsorption ◽  
Chemical Properties ◽  
Adsorption Rate ◽  
Adsorption Method

The presence of malachite green dye in wastewater has a great negative impact on the environment. At present, industrial wastewater is treated using adsorption, electrolysis and membrane separation, among which the adsorption method is the most widely used wastewater treatment. In this study mesoporous silica nanoparticles (MSNs) were prepared using the sol-gel method and modified with the natural polymer urushiol (U) to obtain MSN@Us, which have a core-shell structure. This is the first use of urushiol in dye adsorption. The structures and chemical properties of the MSNs and MSN@Us were characterized. The adsorption of malachite green by the MSNs and MSN@Us showed that the adsorption rate of MSN@Us was higher than that of MSNs, with an adsorption rate greater than 90%. This study provides a new research direction for the use of urushiol in the treatment of contaminated wastewater.

Design of a versatile nanocomposite for ‘seeing’ drug release and action behavior

2015 ◽  
Vol 3 (43) ◽  
pp. 8449-8458 ◽  
Author(s):  
Yu Zhang ◽  
Tingting Shen ◽  
Xia Deng ◽  
Yufei Ma ◽  
Lina Wang ◽  
...  
Keyword(s):  
Rare Earth ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Real Time ◽  
Mesoporous Silica Nanoparticles ◽  
Magnetic Core ◽  
New Method ◽  
Rare Earth Complex ◽  
Real Time Monitoring

To design a new method for ‘seeing’ drug release and action behavior, we combined a rare-earth complex with a magnetic-core-coated phenyl mesoporous silica nanoparticles matrix, taking advantage of the drug coordination for real-time monitoring.

Green Synthesis of AgNPs Coated Mesoporous Silica Nanoparticles Using Tyrosine as Reducing/Stabilising Agent

2018 ◽  
Vol 928 ◽  
pp. 89-93 ◽  
Author(s):  
Waranya Ratirotjanakul ◽  
Tanapon Sioloetwong ◽  
Teeraporn Suteewong ◽  
Pramuan Tangboriboonrat
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
High Speed ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carrier ◽  
Sol Gel ◽  
Visible Absorption ◽  
Sol Gel Process ◽  
Phenolic Group ◽  
Uv Visible

A novel, simple and environmental friendly approach to fabricate silver nanoparticles (AgNPs) on mesoporous silica nanoparticles (MSNs) using tyrosine (Tyr) as biological reducing agent was developed. The functionalization of Tyr with MSNs (Tyr-MSNs) (150 nm in length) by the sol-gel process was confirmed by the characteristic peaks of amino, carboxyl and silanol groups appeared in FTIR spectrum and the change of the zeta potential from 0 mV at pH 2 to-60 mV at pH 12. Then, AgNPs were formed on the surface of Tyr-MSNs (Tyr-MSN@AgNPs) via only reducibility from phenolic group of Tyr and catalytic activity from base at room temperature. TEM images and UV-Visible absorption band at 420 nm supported the obtained AgNPs (18 nm at pH 11) were tightly bound to Tyr-MSNs even after centrifugation at high speed. These Tyr-MSN@AgNPs would be potentially used as drug carrier in biomedical applications.

Delocalization of electronic states in graphene oxide stabilised mesoporous silica nanoparticles revealed using photoluminescence

RSC Advances ◽  
2014 ◽  
Vol 4 (34) ◽  
pp. 17879-17883 ◽  
Author(s):  
Naveen Chandrasekaran ◽  
Santhana Sivabalan ◽  
Aswin Prathap ◽  
S. Mohan ◽  
R. Jagannathan
Keyword(s):  
Graphene Oxide ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Silica Aerogel ◽  
Mesoporous Silica Nanoparticles ◽  
Sol Gel ◽  
Electronic States ◽  
Coordination Complexes ◽  
Sol Gel Process ◽  
Graphene Oxide Sheets

Mesoporous silica aerogel obtained through a sol–gel process when surface treated with 2-D graphene oxide sheets reveals many fascinating features particularly, leading to multiple coordination complexes based on amide linkages.

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