Preparation of Mesoporous Silica Nanoparticles Modified by Urushiol and Their Adsorption on Malachite Green

2021 ◽  
Vol 21 (9) ◽  
pp. 4792-4796
Author(s):  
Xue-Qing Xiao ◽  
Zhi-Yu Chen ◽  
Jia-Wen Chen ◽  
Qin-Hui Chen
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Malachite Green ◽  
Negative Impact ◽  
Mesoporous Silica Nanoparticles ◽  
Sol Gel ◽  
Dye Adsorption ◽  
Chemical Properties ◽  
Adsorption Rate ◽  
Adsorption Method

The presence of malachite green dye in wastewater has a great negative impact on the environment. At present, industrial wastewater is treated using adsorption, electrolysis and membrane separation, among which the adsorption method is the most widely used wastewater treatment. In this study mesoporous silica nanoparticles (MSNs) were prepared using the sol-gel method and modified with the natural polymer urushiol (U) to obtain MSN@Us, which have a core-shell structure. This is the first use of urushiol in dye adsorption. The structures and chemical properties of the MSNs and MSN@Us were characterized. The adsorption of malachite green by the MSNs and MSN@Us showed that the adsorption rate of MSN@Us was higher than that of MSNs, with an adsorption rate greater than 90%. This study provides a new research direction for the use of urushiol in the treatment of contaminated wastewater.

scholarly journals Mesoporous Silica Nanoparticles for Targeting Subcellular Organelles

2020 ◽  
Vol 21 (24) ◽  
pp. 9696
Author(s):  
Miguel Gisbert-Garzarán ◽  
Daniel Lozano ◽  
María Vallet-Regí
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
State Of The Art ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Distribution ◽  
Chemical Properties ◽  
Drug Carriers ◽  
Subcellular Organelles ◽  
Physico Chemical ◽  
Tumoral Cells

Current chemotherapy treatments lack great selectivity towards tumoral cells, which leads to nonspecific drug distribution and subsequent side effects. In this regard, the use of nanoparticles able to encapsulate and release therapeutic agents has attracted growing attention. In this sense, mesoporous silica nanoparticles (MSNs) have been widely employed as drug carriers owing to their exquisite physico-chemical properties. Because MSNs present a surface full of silanol groups, they can be easily functionalized to endow the nanoparticles with many different functionalities, including the introduction of moieties with affinity for the cell membrane or relevant compartments within the cell, thus increasing the efficacy of the treatments. This review manuscript will provide the state-of-the-art on MSNs functionalized for targeting subcellular compartments, focusing on the cytoplasm, the mitochondria, and the nucleus.

scholarly journals Amine-Functionalized Mesoporous Silica Nanoparticles: A New Nanoantibiotic for Bone Infection Treatment

2017 ◽  
Vol 3 (1) ◽  
Author(s):  
Daniel Pedraza ◽  
Jaime Díez ◽  
Isabel Izquierdo-Barba ◽  
Montserrat Colilla ◽  
María Vallet-Regí
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Chemical Properties ◽  
Bone Infection ◽  
Bacterial Biofilm ◽  
Functionalized Mesoporous Silica ◽  
Transmission Electron ◽  
Infection Treatment ◽  
Physical And Chemical

AbstractThis manuscript reports an effective new alternative for the management of bone infection by the development of an antibiotic nanocarrier able to penetrate bacterial biofilm, thus enhancing antimicrobial effectiveness. This nanosystem, also denoted as “nanoantibiotic”, consists in mesoporous silica nanoparticles (MSNs) loaded with an antimicrobial agent (levofloxacin, LEVO) and externally functionalized with N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (DAMO) as targeting agent. This amine functionalization provides MSNs of positive charges, which improves the affinity towards the negatively charged bacteria wall and biofilm. Physical and chemical properties of the nanoantibiotic were studied using different characterization techniques, including Xray diffraction (XRD), transmission electron microscopy (TEM), N

scholarly journals Large Pore Mesoporous Silica and Organosilica Nanoparticles for Pepstatin A Delivery in Breast Cancer Cells

Molecules ◽  
2019 ◽  
Vol 24 (2) ◽  
pp. 332 ◽  
Author(s):  
Saher Rahmani ◽  
Jelena Budimir ◽  
Mylene Sejalon ◽  
Morgane Daurat ◽  
Dina Aggad ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Cathepsin D ◽  
Breast Cancer Cells ◽  
Potent Inhibitor ◽  
Mesoporous Silica Nanoparticles ◽  
Sol Gel ◽  
Pepstatin A

(1) Background: Nanomedicine has recently emerged as a new area of research, particularly to fight cancer. In this field, we were interested in the vectorization of pepstatin A, a peptide which does not cross cell membranes, but which is a potent inhibitor of cathepsin D, an aspartic protease particularly overexpressed in breast cancer. (2) Methods: We studied two kinds of nanoparticles. For pepstatin A delivery, mesoporous silica nanoparticles with large pores (LPMSNs) and hollow organosilica nanoparticles (HOSNPs) obtained through the sol–gel procedure were used. The nanoparticles were loaded with pepstatin A, and then the nanoparticles were incubated with cancer cells. (3) Results: LPMSNs were monodisperse with 100 nm diameter. HOSNPs were more polydisperse with diameters below 100 nm. Good loading capacities were obtained for both types of nanoparticles. The nanoparticles were endocytosed in cancer cells, and HOSNPs led to the best results for cancer cell killing. (4) Conclusions: Mesoporous silica-based nanoparticles with large pores or cavities are promising for nanomedicine applications with peptides.

A new method for loading mesoporous silica nanoparticles with drugs: Sol–gel synthesis using drug micelles as a template

2016 ◽  
Vol 78 (5) ◽  
pp. 586-595 ◽  
Author(s):  
O. V. Dement’eva ◽  
I. N. Senchikhin ◽  
M. E. Kartseva ◽  
V. A. Ogarev ◽  
A. V. Zaitseva ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Sol Gel ◽  
New Method ◽  
Sol Gel Synthesis

scholarly journals Macrophage-like THP-1 cells show effective uptake of silica nanoparticles carrying inactivated diphtheria toxoid for vaccination

2020 ◽  
Vol 22 (1) ◽  
Author(s):  
Xinyue Huang ◽  
Danielle Paixão Cavalcante ◽  
Helen E Townley
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Sol Gel ◽  
Porous Silica ◽  
Diphtheria Toxoid ◽  
Similar Distribution ◽  
Antigen Delivery ◽  
Before And After ◽  
Post Synthesis

AbstractNanoparticles may be used in vaccinology as an antigen delivery and/or an immunostimulant to enhance immunity. Porous silica has been identified as an effective adjuvant for more than a decade, and we have therefore investigated the take up rate by an immortalized macrophage-like cell line of a number of mesoporous silica nanoparticles (MSNPs) with differing diameter and pore size. The MSNPs were synthesized using a sol-gel reaction and post-synthesis removal of the template. The MSNPs showed a clear distribution in take up rate peaking at 217 nm, whereas a comparison with solid spherical nanoparticles showed a similar distribution peaking at 377 nm. The MSNPs were investigated before and after loading with antigen. Diphtheria toxoid was used as a proof-of-concept antigen and showed a peak macrophage internalization of 53.42% for loaded LP3 particles which had a diameter of 217.75 ± 5.44 nm and large 16.5 nm pores. Optimal MSNP sizes appeared to be in the 200–400 nm range, and larger pores showed better antigen loading. The mesoporous silica particles were shown to be generally biocompatible, and cell viability was not altered by the loading of particles with or without antigen.

Fabrication of mesoporous silica nanoparticles by sol gel method followed various hydrothermal temperature

2018 ◽  
Author(s):  
Hariyati Purwaningsih ◽  
Vania Mitha Pratiwi ◽  
Siti Annisa Bani Purwana ◽  
Haniffudin Nurdiansyah ◽  
Yenny Rahmawati ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Sol Gel ◽  
Hydrothermal Temperature ◽  
Gel Method ◽  
Sol Gel Method

scholarly journals Air Pollution Method: A new method based on ionic liquid passed on mesoporous silica nanoparticles for removal of manganese dust in the workplace air

2019 ◽  
Vol 2 (01) ◽  
pp. 5-14 ◽  
Author(s):  
Parisa Paydar ◽  
Ali Faghihi Zarandi
Keyword(s):  
Ionic Liquid ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Solid Phase ◽  
Mesoporous Silica Nanoparticles ◽  
Adsorption Method ◽  
Adsorption Removal ◽  
Workplace Air ◽  
Set Up ◽  
System 1

Chronic effect of manganese exposure to humans caused the dysfunction of nervous system. An applied sorbent based on hydrophobic ionic liquid passed on mesoporous silica nanoparticles was used for adsorption/removal of manganese dust (Mn) from workplace air by solid phase adsorption method. In bench scale set up, 5 mL of standard solution of nitrate and oxide of Mn (0.2-5 mg L-1) was used for generation of manganese dust in pure air by drying procedure, and then was passed through column of IL/MSNPs by SKC pump with flow rate  of 200-500 mL min-1 by SKC pump. The Mn particles separated from column of IL/MSNPs by irrigation of nitric acid solution before determined by F-AAS/ET-AAS. In optimized conditions, the adsorption capacity of MSNPs and IL/MSNPs for Mn removal from air in batch system (1 Li) was obtained 118.5 mg g-1 and 216.2 mg g-1, respectively.

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