Model of controlled drug release from functionalized magnetic nanoparticles by a nonheating alternating-current magnetic field

2016 ◽  
Vol 42 (3) ◽  
pp. 267-270 ◽  
Author(s):  
Yu. I. Golovin ◽  
N. L. Klyachko ◽  
S. L. Gribanovskii ◽  
D. Yu. Golovin ◽  
A. G. Majouga
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Alternating Current ◽  
Functionalized Magnetic Nanoparticles ◽  
Current Magnetic Field

scholarly journals Combined Magnetoliposome Formation and Drug Loading in One Step for Efficient Alternating Current-Magnetic Field Remote-Controlled Drug Release

2020 ◽  
Vol 12 (4) ◽  
pp. 4295-4307 ◽  
Author(s):  
Maria Eugenia Fortes Brollo ◽  
Ana Domínguez-Bajo ◽  
Andrea Tabero ◽  
Vicente Domínguez-Arca ◽  
Victor Gisbert ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Release ◽  
Drug Loading ◽  
Controlled Drug Release ◽  
Alternating Current ◽  
One Step ◽  
Current Magnetic Field

scholarly journals Magnetic Nanoparticles In Hyperthermia Therapy: A Mini-Review

2021 ◽  
Vol 2 (1) ◽  
pp. 51-60
Author(s):  
Mostafa Yusefi ◽  
Kamyar Shameli ◽  
Siti Nur Amalina Mohamad Sukri
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Magnetic Hyperthermia ◽  
Alternating Magnetic Field ◽  
Tumor Type ◽  
Heating Efficiency ◽  
Heating Source ◽  
Hyperthermia Therapy

The activation of MNPs for hyperthermia therapy via an external alternating magnetic field is an interesting method in targeted cancer therapy. This mini-review explains new developments and implications of magnetic nanofluids mediated magnetic hyperthermia for their potential use in future clinical settings. The external alternating magnetic field generates heat in the tumor area to eliminate cancer cells. Depending on the tumor type and targeted area, several kinds of MNPs with different coating agents of various morphology and surface charge have been developed. The tunable physiochemical characteristics of MNPs enhance their heating capability. In addition, heating efficiency is strongly associated with the amount of the applied magnetic field and frequency. The great efforts have offered promising preclinical trials of magnetic hyperthermia via MNPs as a smart nanoagent. MNPs are very appropriate to be considered as a heating source in MHT and prospective research in this field will lead to tackle the problems from chemotherapy and introduce promising therapeutic techniques and nanodrug formulations for remotely controlled drug release and anticancer effects. This mini-review aims to pinpoint synthesis and structural analysis of various magnetic nanoparticles examined for magnetic hyperthermia therapy and controlled drug release in cancer treatment.

scholarly journals Magnetic liposome design for drug release systems responsive to super-low frequency alternating current magnetic field (AC MF)

2019 ◽  
Vol 552 ◽  
pp. 689-700 ◽  
Author(s):  
Kseniya Yu. Vlasova ◽  
Alexander Piroyan ◽  
Irina M. Le-Deygen ◽  
Hemant M. Vishwasrao ◽  
Jacob D. Ramsey ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Release ◽  
Low Frequency ◽  
Alternating Current ◽  
Current Magnetic Field

Remote magnetically controlled drug release from electrospun composite nanofibers: design of a smart platform for therapy of psoriasis

2020 ◽  
Vol 75 (7) ◽  
pp. 587-591
Author(s):  
Natália Babincová ◽  
Oldřich Jirsák ◽  
Melánia Babincová ◽  
Peter Babinec ◽  
Mária Šimaljaková
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Drug Release ◽  
Polyvinyl Alcohol ◽  
Efficient Method ◽  
Large Scale ◽  
Composite Nanofibers ◽  
Controlled Drug Release ◽  
Stimuli Responsive ◽  
Nano Fiber

AbstractAn efficient method for the large-scale fabrication of composite polyvinyl alcohol polymer nano fibers loaded with magnetic nanoparticles and methotrexate is reported in this study. We have demonstrated that nonwoven textile formed by needleless electro spinning is effective in immobilization and triggered the release of drugs, which is achieved by an alternating magnetic field induced heating of magnetic nanoparticles. This smart stimuli-responsive release ability, biocompatibility, and ultra-lightweight property render enormous potential for this electrospun nano fiber mat to be used as an anti-psoriatic drugs release platform, which may have far-reaching applications in dermatology.

scholarly journals Design for a Persistent Current Switch Controlled by Alternating Current Magnetic Field

2018 ◽  
Vol 28 (4) ◽  
pp. 1-5 ◽  
Author(s):  
Chao Li ◽  
Jianzhao Geng ◽  
Jamie Gawith ◽  
Boyang Shen ◽  
Xiuchang Zhang ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Alternating Current ◽  
Persistent Current ◽  
Current Switch ◽  
Current Magnetic Field

AC-magnetic field controlled drug release from magnetoliposomes: design of a method for site-specific chemotherapy

2002 ◽  
Vol 55 (1-2) ◽  
pp. 17-19 ◽  
Author(s):  
M Babincová ◽  
P Čičmanec ◽  
V Altanerová ◽  
Č Altaner ◽  
P Babinec
Keyword(s):  
Magnetic Field ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Site Specific ◽  
Ac Magnetic Field

An efficient synthesis of ferumoxytol induced by alternating-current magnetic field

2016 ◽  
Vol 170 ◽  
pp. 93-96 ◽  
Author(s):  
Bo Chen ◽  
Yang Li ◽  
Xiquan Zhang ◽  
Fei Liu ◽  
Yanlong Liu ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Alternating Current ◽  
Efficient Synthesis ◽  
Current Magnetic Field

scholarly journals Enhanced Cancer Cell (HeLa) Killing Efficacy of Mixed Αlpha and Gamma Iron Oxide Superparamagnetic Nanoparticles under Combined AC (Alternating Current) Magnetic-Field and Photoexcitation

1970 ◽  
Vol 12 (4) ◽  
Author(s):  
Md. Shariful Islam, Yoshihumi Kusumoto, Md. Abdulla Al-Mamun And Yuji Horie
Keyword(s):  
Magnetic Field ◽  
Iron Oxide ◽  
Hela Cells ◽  
Room Temperature ◽  
Heat Dissipation ◽  
Alternating Current ◽  
Superparamagnetic Nanoparticles ◽  
Gamma Iron ◽  
Ac Magnetic Field ◽  
Current Magnetic Field

We synthesized mixed α and γ-Fe2O3 nanoparticles and investigated their toxic effects against HeLa cells under induced AC (alternating current) magnetic-fields and photoexcited conditions at room temperature. The findings revealed that the cell-killing percentage was increased with increasing dose for all types of treatments. Finally, 99% cancer cells were destructed at 1.2 mL dose when exposed to combined AC magnetic-field and photoexcited conditions (T3) whereas 89 and 83 % of HeLa cells were killed under only AC magnetic-field induced (T1) or only photoexcited (T2) condition at the same dose.ABSTRAK: Campuran α dan zarah γ-Fe2O3 bersaiz nano disintesiskan dan kesan toksidnya terhadap sel HeLa dikaji dibawah aruhan medan magnet arus ulang-alik (alternating current (AC)) dan keadaan photoexcited (proses ransangan atom atau molekul suatu bahan dengan penyerapan tenaga sinaran) pada suhu bilik. Penemuan mendedahkan bahawa peratusan sel yang musnah bertambah dengan pertambahan dos untuk semua jenis rawatan. Akhirnya, 99% sel kanser dimusnahkan pada kadar dos 1.2mL setelah didedahkan terhadap kombinasi medan magnet AC dan keadaan photoexcited (T3) dimana 89% dan 83% sel HeLa dimusnahkan dengan hanya di bawah aruhan medan magnet AC (T1) atau hanya pada keadaan photoexcited (T2) pada kadar dos yang sama.KEY WORDS : Cancer, Hyperthermia, Iron oxide nanoparticles, Heat dissipation,    Cytotoxicity, HeLa cell.

scholarly journals Carbon-Based Magnetic Nanocarrier for Controlled Drug Release: A Green Synthesis Approach

2018 ◽  
Vol 5 (1) ◽  
pp. 1 ◽  
Author(s):  
Jessica Oliveira ◽  
Raquel Rodrigues ◽  
Lillian Barros ◽  
Isabel Ferreira ◽  
Luís Marchesi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Drug Release ◽  
Phosphate Buffer ◽  
Colloidal Stability ◽  
Ph Dependence ◽  
Phosphate Buffer Solution ◽  
Controlled Drug Release ◽  
Buffer Solution ◽  
Carbon Based

In this study, hydrophilic magnetic nanoparticles were synthesized by green routes using a methanolic extract of Rubus ulmifolius Schott flowers. The prepared magnetic nanoparticles were coated with carbon-based shell for drug delivery application. The nanocomposites were further chemically functionalized with nitric acid and, sequentially, with Pluronic® F68 (CMNPs-plur) to enhance their colloidal stability. The resulting material was dispersed in phosphate buffer solution at pH 7.4 to study the Doxorubicin loading. After shaking for 48 h, 99.13% of the drug was loaded by the nanocomposites. Subsequently, the drug release was studied in different working phosphate buffer solutions (i.e., PB pH 4.5, pH 6.0 and pH 7.4) to determine the efficiency of the synthesized material for drug delivery as pH-dependent drug nanocarrier. The results have shown a drug release quantity 18% higher in mimicking tumor environment than in the physiological one. Therefore, this study demonstrates the ability of CMNPs-plur to release a drug with pH dependence, which could be used in the future for the treatment of cancer "in situ" by means of controlled drug release.

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