Remote magnetically controlled drug release from electrospun composite nanofibers: design of a smart platform for therapy of psoriasis

AbstractAn efficient method for the large-scale fabrication of composite polyvinyl alcohol polymer nano fibers loaded with magnetic nanoparticles and methotrexate is reported in this study. We have demonstrated that nonwoven textile formed by needleless electro spinning is effective in immobilization and triggered the release of drugs, which is achieved by an alternating magnetic field induced heating of magnetic nanoparticles. This smart stimuli-responsive release ability, biocompatibility, and ultra-lightweight property render enormous potential for this electrospun nano fiber mat to be used as an anti-psoriatic drugs release platform, which may have far-reaching applications in dermatology.

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Model of controlled drug release from functionalized magnetic nanoparticles by a nonheating alternating-current magnetic field

Technical Physics Letters ◽

10.1134/s1063785016030056 ◽

2016 ◽

Vol 42 (3) ◽

pp. 267-270 ◽

Cited By ~ 4

Author(s):

Yu. I. Golovin ◽

N. L. Klyachko ◽

S. L. Gribanovskii ◽

D. Yu. Golovin ◽

A. G. Majouga

Keyword(s):

Magnetic Field ◽

Magnetic Nanoparticles ◽

Drug Release ◽

Controlled Drug Release ◽

Alternating Current ◽

Functionalized Magnetic Nanoparticles ◽

Current Magnetic Field

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Magnetic Nanoparticles In Hyperthermia Therapy: A Mini-Review

Journal of Research in Nanoscience and Nanotechnology ◽

10.37934/jrnn.2.1.5160 ◽

2021 ◽

Vol 2 (1) ◽

pp. 51-60

Author(s):

Mostafa Yusefi ◽

Kamyar Shameli ◽

Siti Nur Amalina Mohamad Sukri

Keyword(s):

Magnetic Field ◽

Magnetic Nanoparticles ◽

Drug Release ◽

Controlled Drug Release ◽

Magnetic Hyperthermia ◽

Alternating Magnetic Field ◽

Tumor Type ◽

Heating Efficiency ◽

Heating Source ◽

Hyperthermia Therapy

The activation of MNPs for hyperthermia therapy via an external alternating magnetic field is an interesting method in targeted cancer therapy. This mini-review explains new developments and implications of magnetic nanofluids mediated magnetic hyperthermia for their potential use in future clinical settings. The external alternating magnetic field generates heat in the tumor area to eliminate cancer cells. Depending on the tumor type and targeted area, several kinds of MNPs with different coating agents of various morphology and surface charge have been developed. The tunable physiochemical characteristics of MNPs enhance their heating capability. In addition, heating efficiency is strongly associated with the amount of the applied magnetic field and frequency. The great efforts have offered promising preclinical trials of magnetic hyperthermia via MNPs as a smart nanoagent. MNPs are very appropriate to be considered as a heating source in MHT and prospective research in this field will lead to tackle the problems from chemotherapy and introduce promising therapeutic techniques and nanodrug formulations for remotely controlled drug release and anticancer effects. This mini-review aims to pinpoint synthesis and structural analysis of various magnetic nanoparticles examined for magnetic hyperthermia therapy and controlled drug release in cancer treatment.

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AC-magnetic field controlled drug release from magnetoliposomes: design of a method for site-specific chemotherapy

Bioelectrochemistry ◽

10.1016/s1567-5394(01)00171-2 ◽

2002 ◽

Vol 55 (1-2) ◽

pp. 17-19 ◽

Cited By ~ 123

Author(s):

M Babincová ◽

P Čičmanec ◽

V Altanerová ◽

Č Altaner ◽

P Babinec

Keyword(s):

Magnetic Field ◽

Drug Release ◽

Controlled Drug Release ◽

Site Specific ◽

Ac Magnetic Field

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Bioactive films of zein/magnetite magnetically stimuli-responsive for controlled drug release

Journal of Magnetism and Magnetic Materials ◽

10.1016/j.jmmm.2018.03.046 ◽

2018 ◽

Vol 458 ◽

pp. 355-364 ◽

Cited By ~ 2

Author(s):

Tíffany Marín ◽

Paula Montoya ◽

Oscar Arnache ◽

Rodolfo Pinal ◽

Jorge Calderón

Keyword(s):

Drug Release ◽

Controlled Drug Release ◽

Stimuli Responsive

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Carbon-Based Magnetic Nanocarrier for Controlled Drug Release: A Green Synthesis Approach

C – Journal of Carbon Research ◽

10.3390/c5010001 ◽

2018 ◽

Vol 5 (1) ◽

pp. 1 ◽

Cited By ~ 1

Author(s):

Jessica Oliveira ◽

Raquel Rodrigues ◽

Lillian Barros ◽

Isabel Ferreira ◽

Luís Marchesi ◽

...

Keyword(s):

Drug Delivery ◽

Magnetic Nanoparticles ◽

Drug Release ◽

Phosphate Buffer ◽

Colloidal Stability ◽

Ph Dependence ◽

Phosphate Buffer Solution ◽

Controlled Drug Release ◽

Buffer Solution ◽

Carbon Based

In this study, hydrophilic magnetic nanoparticles were synthesized by green routes using a methanolic extract of Rubus ulmifolius Schott flowers. The prepared magnetic nanoparticles were coated with carbon-based shell for drug delivery application. The nanocomposites were further chemically functionalized with nitric acid and, sequentially, with Pluronic® F68 (CMNPs-plur) to enhance their colloidal stability. The resulting material was dispersed in phosphate buffer solution at pH 7.4 to study the Doxorubicin loading. After shaking for 48 h, 99.13% of the drug was loaded by the nanocomposites. Subsequently, the drug release was studied in different working phosphate buffer solutions (i.e., PB pH 4.5, pH 6.0 and pH 7.4) to determine the efficiency of the synthesized material for drug delivery as pH-dependent drug nanocarrier. The results have shown a drug release quantity 18% higher in mimicking tumor environment than in the physiological one. Therefore, this study demonstrates the ability of CMNPs-plur to release a drug with pH dependence, which could be used in the future for the treatment of cancer "in situ" by means of controlled drug release.

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The Synthesis and Characterization of PVA-Ketoprofen Cryogel, Biomaterial with Extended Drug Release Properties for Cartilage Replacement

Solid State Phenomena ◽

10.4028/www.scientific.net/ssp.216.205 ◽

2014 ◽

Vol 216 ◽

pp. 205-209

Author(s):

Monica Cretan Stamate ◽

Ciprian Stamate

Keyword(s):

Articular Cartilage ◽

Drug Release ◽

Polyvinyl Alcohol ◽

Water Solubility ◽

Physicochemical Characterization ◽

Gravimetric Method ◽

Controlled Drug Release ◽

High Wear Resistance ◽

Mechanical Resistance ◽

Swelling Properties

The present paper aims to study the possibility to modify the properties of polyvinyl alcohol (pva) cryogels prepared in the presence of ketoprofen in order to replace the damaged articular cartilage. Articular cartilage is the most important part of articulation characterized by very low friction, high wear resistance, and poor regenerative qualities. Polyvinyl alcohol is a non-expensive polymer, versatile and adaptable to various needs, with exceptional properties such as water solubility, biocompatibility, non-toxicity and with capability to form hydrogels by chemical or physical methods. The aims of this paper are the synthesis, the physicochemical characterization and analysis of the tribological properties of pva cryogels for cartilage replacement and the introduction of new concept in medication by creating the cryogel like a controlled drug release system. The morphology of the cryogels, the interaction between the pva macromolecular chains and medicament has been studied by Scanning Electronic Microscopy. The gels swelling in physiologic ser have been monitored by gravimetric method in order to evidence the hydrophilic properties. The mechanical properties of the cryogels have been investigated by dynamic mechanical measurements. In conclusion, the biomaterial obtained provides good swelling properties, mechanical resistance and it is ideal for extended drug release implantable systems.

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