scholarly journals Magnetic Nanoparticles In Hyperthermia Therapy: A Mini-Review

2021 ◽  
Vol 2 (1) ◽  
pp. 51-60
Author(s):  
Mostafa Yusefi ◽  
Kamyar Shameli ◽  
Siti Nur Amalina Mohamad Sukri
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Magnetic Hyperthermia ◽  
Alternating Magnetic Field ◽  
Tumor Type ◽  
Heating Efficiency ◽  
Heating Source ◽  
Hyperthermia Therapy

The activation of MNPs for hyperthermia therapy via an external alternating magnetic field is an interesting method in targeted cancer therapy. This mini-review explains new developments and implications of magnetic nanofluids mediated magnetic hyperthermia for their potential use in future clinical settings. The external alternating magnetic field generates heat in the tumor area to eliminate cancer cells. Depending on the tumor type and targeted area, several kinds of MNPs with different coating agents of various morphology and surface charge have been developed. The tunable physiochemical characteristics of MNPs enhance their heating capability. In addition, heating efficiency is strongly associated with the amount of the applied magnetic field and frequency. The great efforts have offered promising preclinical trials of magnetic hyperthermia via MNPs as a smart nanoagent. MNPs are very appropriate to be considered as a heating source in MHT and prospective research in this field will lead to tackle the problems from chemotherapy and introduce promising therapeutic techniques and nanodrug formulations for remotely controlled drug release and anticancer effects. This mini-review aims to pinpoint synthesis and structural analysis of various magnetic nanoparticles examined for magnetic hyperthermia therapy and controlled drug release in cancer treatment.

scholarly journals Fundamentals to Apply Magnetic Nanoparticles for Hyperthermia Therapy

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1203
Author(s):  
Hira Fatima ◽  
Tawatchai Charinpanitkul ◽  
Kyo-Seon Kim
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Magnetic Hyperthermia ◽  
Alternating Magnetic Field ◽  
Tumor Type ◽  
Hyperthermia Treatment ◽  
Coating Materials ◽  
Heating Efficiency ◽  
Hyperthermia Therapy ◽  
Corona Formation

The activation of magnetic nanoparticles in hyperthermia treatment by an external alternating magnetic field is a promising technique for targeted cancer therapy. The external alternating magnetic field generates heat in the tumor area, which is utilized to kill cancerous cells. Depending on the tumor type and site to be targeted, various types of magnetic nanoparticles, with variable coating materials of different shape and surface charge, have been developed. The tunable physical and chemical properties of magnetic nanoparticles enhance their heating efficiency. Moreover, heating efficiency is directly related with the product values of the applied magnetic field and frequency. Protein corona formation is another important parameter affecting the heating efficiency of MNPs in magnetic hyperthermia. This review provides the basics of magnetic hyperthermia, mechanisms of heat losses, thermal doses for hyperthermia therapy, and strategies to improve heating efficiency. The purpose of this review is to build a bridge between the synthesis/coating of magnetic nanoparticles and their practical application in magnetic hyperthermia.

scholarly journals Enhancing Magnetic Hyperthermia Nanoparticle Heating Efficiency with Non-Sinusoidal Alternating Magnetic Field Waveforms

Nanomaterials ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 3240
Author(s):  
Michael Zeinoun ◽  
Javier Domingo-Diez ◽  
Miguel Rodriguez-Garcia ◽  
Oscar Garcia ◽  
Miroslav Vasic ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Heat Production ◽  
Power Dissipation ◽  
Magnetic Hyperthermia ◽  
Experimental Results ◽  
Production Performance ◽  
Alternating Magnetic Field ◽  
In Vivo Studies ◽  
Sinusoidal Signals

For decades now, conventional sinusoidal signals have been exclusively used in magnetic hyperthermia as the only alternating magnetic field waveform to excite magnetic nanoparticles. However, there are no theoretical nor experimental reasons that prevent the use of different waveforms. The only justifiable motive behind using the sinusoidal signal is its availability and the facility to produce it. Following the development of a configurable alternating magnetic field generator, we aim to study the effect of various waveforms on the heat production effectiveness of magnetic nanoparticles, seeking to prove that signals with more significant slope values, such as the trapezoidal and almost-square signals, allow the nanoparticles to reach higher efficiency in heat generation. Furthermore, we seek to point out that the nanoparticle power dissipation is dependent on the waveform’s slope and not only the frequency, magnetic field intensity and the nanoparticle size. The experimental results showed a remarkably higher heat production performance of the nanoparticles when exposed to trapezoidal and almost-square signals than conventional sinusoidal signals. We conclude that the nanoparticles respond better to the trapezoidal and almost-square signals. On the other hand, the experimental results were used to calculate the normalized power dissipation value and prove its dependency on the slope. However, adjustments are necessary to the coil before proceeding with in vitro and in vivo studies to handle the magnetic fields required.

scholarly journals Experimental Evaluation on the Heating Efficiency of Magnetoferritin Nanoparticles in an Alternating Magnetic Field

Nanomaterials ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 1457 ◽  
Author(s):  
Huangtao Xu ◽  
Yongxin Pan
Keyword(s):  
Magnetic Field ◽  
Relaxation Time ◽  
Magnetic Hyperthermia ◽  
Alternating Magnetic Field ◽  
Core Size ◽  
Hyperthermia Treatment ◽  
Field Frequency ◽  
Glycerol Water ◽  
Heating Efficiency ◽  
Néel Relaxation

The superparamagnetic substance magnetoferritin is a potential bio-nanomaterial for tumor magnetic hyperthermia because of its active tumor-targeting outer protein shell, uniform and tunable nanosized inner mineral core, monodispersity and good biocompatibility. Here, we evaluated the heating efficiency of magnetoferritin nanoparticles in an alternating magnetic field (AMF). The effects of core-size, Fe concentration, viscosity, and field frequency and amplitude were investigated. Under 805.5 kHz and 19.5 kA/m, temperature rise (ΔT) and specific loss power (SLP) measured on magnetoferritin nanoparticles with core size of 4.8 nm at 5 mg/mL were 14.2 °C (at 6 min) and 68.6 W/g, respectively. The SLP increased with core-size, Fe concentration, AMF frequency, and amplitude. Given that: (1) the SLP was insensitive to viscosity of glycerol-water solutions and (2) both the calculated effective relaxation time and the fitted relaxation time were closer to Néel relaxation time, we propose that the heating generation mechanism of magnetoferritin nanoparticles is dominated by the Néel relaxation. This work provides new insights into the heating efficiency of magnetoferritin and potential future applications for tumor magnetic hyperthermia treatment and heat-triggered drug release.

scholarly journals Stealth Magnetoliposomes Based on Calcium-Substituted Magnesium Ferrite Nanoparticles for Curcumin Transport and Release

2020 ◽  
Vol 21 (10) ◽  
pp. 3641 ◽  
Author(s):  
Beatriz D. Cardoso ◽  
Ana Rita O. Rodrigues ◽  
Bernardo G. Almeida ◽  
Carlos O. Amorim ◽  
Vítor S. Amaral ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Release ◽  
Natural Compound ◽  
Controlled Drug Release ◽  
Magnetic Hyperthermia ◽  
Ferrite Nanoparticles ◽  
Pharmacological Properties ◽  
Magnesium Ferrite ◽  
Superparamagnetic Properties ◽  
Over Time

Despite the promising pharmacological properties of curcumin, the transport and effective release of curcumin is still a challenge. The advances in functionalized nanocarriers for curcumin have also been motivated by the anticancer activity of this natural compound, aiming at targeted therapies. Here, stealth (aqueous and solid) magnetoliposomes containing calcium-substituted magnesium ferrite nanoparticles, CaxMg1−xFe2O4 (with x = 0.25, 0.50, 0.75) were developed as nanocarriers for curcumin. The magnetic nanoparticles exhibit superparamagnetic properties and crystalline structure, with sizes below 10 nm. The magnetoliposomes based on these nanoparticles have hydrodynamic diameters around or below 150 nm and a low polydispersity. The influence of an alternating magnetic field (AMF) on drug release over time was evaluated and compared with curcumin release by diffusion. The results suggest the potential of drug-loaded magnetoliposomes as nanocarriers that can be magnetically guided to the tumor sites and act as agents for a synergistic effect combining magnetic hyperthermia and controlled drug release.

scholarly journals Iron Oxide Nanoparticles for Magnetic Hyperthermia

SPIN ◽  
2019 ◽  
Vol 09 (02) ◽  
pp. 1940001 ◽  
Author(s):  
N. A. Usov
Keyword(s):  
Magnetic Field ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Stochastic Equation ◽  
Sharp Decrease ◽  
Dipole Interaction ◽  
Magnetic Hyperthermia ◽  
Alternating Magnetic Field ◽  
Oxide Nanoparticles

Assemblies of magnetic nanoparticles show a great potential for application in biomedicine, particularly, magnetic hyperthermia. However, to achieve desired therapeutic effect in magnetic hyperthermia, the assembly of nanoparticles should have a sufficiently high specific absorption rate (SAR) in alternating magnetic field of moderate amplitude and frequency. Using the Landau–Lifshitz stochastic equation, it is shown that dilute assemblies of iron oxide nanoparticles of optimal diameters are capable of providing SAR of the order of 400–600[Formula: see text]W/g in alternating magnetic field with the amplitude [Formula: see text][Formula: see text]Oe in the frequency range f = 300–500[Formula: see text]kHz. Unfortunately, in dense clusters of magnetic nanoparticles, which are often formed in a biological medium, there is a sharp decrease in SAR due to the influence of strong magneto-dipole interaction of closest nanoparticles. To overcome this difficulty, it is suggested covering the nanoparticles with nonmagnetic shells of sufficient thickness or using non-single-domain nanoparticles being in magnetization curling states.

scholarly journals Heating Efficiency of Triple Vortex State Cylindrical Magnetic Nanoparticles

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
De Wei Wong ◽  
Wei Liang Gan ◽  
Yuan Kai Teo ◽  
Wen Siang Lew
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Magnetic Fields ◽  
Vortex State ◽  
Magnetic Hyperthermia ◽  
Relaxation Mechanism ◽  
Micromagnetic Simulations ◽  
Heating Efficiency ◽  
Aspect Ratios ◽  
Low Field

AbstractA well-established method for treating cancerous tumors is magnetic hyperthermia, which uses localized heat generated by the relaxation mechanism of magnetic nanoparticles (MNPs) in a high-frequency alternating magnetic field. In this work, we investigate the heating efficiency of cylindrical NiFe MNPs, fabricated by template-assisted pulsed electrodeposition combined with differential chemical etching. The cylindrical geometry of the MNP enables the formation of the triple vortex state, which increases the heat generation efficiency by four times. Using time-dependent calorimetric measurements, the specific absorption rate (SAR) of the MNPs was determined and compared with the numerical calculations from micromagnetic simulations and vibrating sample magnetometer measurements. The magnetization reversal of high aspect ratios MNPs showed higher remanent magnetization and low-field susceptibility leading to higher hysteresis losses, which was reflected in higher experimental and theoretical SAR values. The SAR dependence on magnetic field strength exhibited small SAR values at low magnetic fields and saturates at high magnetic fields, which is correlated to the coercive field of the MNPs and a characteristic feature of ferromagnetic MNPs. The optimization of cylindrical NiFe MNPs will play a pivotal role in producing high heating performance and biocompatible magnetic hyperthermia agents.

scholarly journals Biocompatible and stable magnetosome minerals coated with poly-l-lysine, citric acid, oleic acid, and carboxy-methyl-dextran for application in the magnetic hyperthermia treatment of tumors

2017 ◽  
Vol 5 (36) ◽  
pp. 7644-7660 ◽  
Author(s):  
Chalani Mandawala ◽  
Imène Chebbi ◽  
Mickael Durand-Dubief ◽  
Raphael Le Fèvre ◽  
Yasmina Hamdous ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Oleic Acid ◽  
Magnetic Nanoparticles ◽  
Citric Acid ◽  
Magnetic Hyperthermia ◽  
Alternating Magnetic Field ◽  
Hyperthermia Treatment ◽  
Carboxy Methyl

Magnetic hyperthermia in which magnetic nanoparticles are introduced into tumors and exposed to an alternating magnetic field, appears to be promising.

Remote magnetically controlled drug release from electrospun composite nanofibers: design of a smart platform for therapy of psoriasis

2020 ◽  
Vol 75 (7) ◽  
pp. 587-591
Author(s):  
Natália Babincová ◽  
Oldřich Jirsák ◽  
Melánia Babincová ◽  
Peter Babinec ◽  
Mária Šimaljaková
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Drug Release ◽  
Polyvinyl Alcohol ◽  
Efficient Method ◽  
Large Scale ◽  
Composite Nanofibers ◽  
Controlled Drug Release ◽  
Stimuli Responsive ◽  
Nano Fiber

AbstractAn efficient method for the large-scale fabrication of composite polyvinyl alcohol polymer nano fibers loaded with magnetic nanoparticles and methotrexate is reported in this study. We have demonstrated that nonwoven textile formed by needleless electro spinning is effective in immobilization and triggered the release of drugs, which is achieved by an alternating magnetic field induced heating of magnetic nanoparticles. This smart stimuli-responsive release ability, biocompatibility, and ultra-lightweight property render enormous potential for this electrospun nano fiber mat to be used as an anti-psoriatic drugs release platform, which may have far-reaching applications in dermatology.

Mechanically Milled Co1-xFexO4 Nanocrystalline for Magnetic Hyperthermia Application

2019 ◽  
Vol 59 ◽  
pp. 25-34
Author(s):  
O.M Lemine ◽  
Sharif Abu Alrub
Keyword(s):  
Magnetic Field ◽  
Magnetic Measurements ◽  
Magnetic Hyperthermia ◽  
Annealed Sample ◽  
Alternating Magnetic Field ◽  
Mass Ratio ◽  
X Ray Diffraction ◽  
Heating Efficiency ◽  
Powder Mass

Mechanical alloying of a mixture of Fe2O3 and CoO powders has been applied for the preparation of nanocrystalline. Utilizing a ball-to-powder mass ratio of 20, milling time of 20 hours followed by annealing at 900°C, we could obtain a nanocrystalline of high crystallinity and composed of mainly CoFe2O4 phase with presence of Fe2O3 as revealed by X-ray diffraction (XRD) measurements. Magnetic measurements using vibrating sample magnetometer (VSM) reveal high saturation magnetization for the annealed sample close to CoFe2O4 phase value. The heating efficiency of the obtained nanocrystalline is studied under an alternating magnetic field and as a function of the concentration. It was found that the nanocrystalline generate a substantial amount of heat when exposed to an alternating magnetic field. In vitro hyperthermia experiment was carried out and our result clearly demonstrates the ability of the obtained nanocrystalline to kill cancer cell through magnetic hyperthermia.

Sign in / Sign up

Export Citation Format

Share Document