Patterns of Vertebral Pain Syndromes in Women of Older Age Groups Depending on Duration of Postmenopausal Period and Bone Mineral Density Score

2017 ◽  
Vol 7 (4) ◽  
pp. 328-335
Author(s):  
T. V. Orlyk ◽  
N. V. Grygorieva ◽  
V. V. Povoroznyuk
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Age Groups ◽  
Older Age ◽  
Mineral Density ◽  
Pain Syndromes ◽  
Density Score ◽  
Postmenopausal Period

scholarly journals Vitamin D and bone mineral density status among postmenopausal Bangladeshi women

2019 ◽  
Vol 12 (2) ◽  
pp. 44-49
Author(s):  
AKM Shaheen Ahmed ◽  
Wasim Md Mohosin Ul Haque ◽  
Khwaja Nazim Uddin ◽  
Fadlul Azim Abrar ◽  
Farhana Afroz ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Age Groups ◽  
Urban Hospital ◽  
Mineral Density ◽  
Cross Sectional ◽  
Serum Ipth ◽  
Vitamin D Levels

Background and objectives: Low vitamin D is a global problem in all age groups as is osteoporosis in postmenopausal women. The present study was carried out in an urban hospital to assess serum 25-hydroxyvitamin D [25(OH)D] level and bone mineral density (BMD) in postmenopausal women (PMW) and to evaluate correlation between serum 25(OH)D levels and BMD. Methods: A single center cross-sectional study was conducted among 133 apparently healthy PMW aged 45 years and above with the history of complete cessation of menstruation over a period of more than 1 year. Serum 25(OH)D, BMD and serum intact parathyroid hormone (iPTH) were determined. Patients having both vitamin D and BMD values were analyzed for correlations. Similarly, correlation of vitamin D, iPTH and BMD were determined. Results: Among the study population, 63 (47.4%) had deficient (<20 ng/ml), 46 (34.6%) had insufficient (20-30ng/ml) and 24(18%) had sufficient (30-100ng/ml) levels of serum 25(OH)D. Among the 121 patients whose BMD was done, 52 (43.0%) and 60 (49.6%) had osteoporosis and osteopenia respectively. Serum iPTH levels were normal in 34 (89.5%) patients. The proportion of osteopenia and osteoporosis in vitamin D deficient group were 44.1% and 50.8% and in insufficient group 47.5 and 45.0%, respectively. Age had significant negative correlation with BMD value (r=-0.246, p=.005) and significant positive correlation with serum iPTH (r=0.358, p=.024). There was no statistically significant influence of serum 25(OH)D or iPTH on occurrence of osteoporosis (P=0.322 and P=0.592 respectively). Conclusion: A large proportion of postmenopausal women had low vitamin D levels and as well as osteopenia and osteoporosis. Low vitamin D level coexisted with low BMD. However, there was no correlation between serum 25(OH)D levels and BMD status. IMC J Med Sci 2018; 12(2): 44-49

scholarly journals Parathyroid Hormone and Bone Mineral Density: A Mendelian Randomization Study

2020 ◽  
Vol 105 (11) ◽  
Author(s):  
Zihao Qu ◽  
Fangkun Yang ◽  
Jianqiao Hong ◽  
Wei Wang ◽  
Shigui Yan
Keyword(s):  
Bone Mineral Density ◽  
Parathyroid Hormone ◽  
Bone Mineral ◽  
Large Scale ◽  
Genome Wide Association Study ◽  
Mendelian Randomization ◽  
Causal Effect ◽  
Age Groups ◽  
Mineral Density ◽  
Serum Pth

Abstract Purpose Accumulating evidence implicates parathyroid hormone (PTH) in the development of osteoporosis. However, the causal effect of PTH on bone mineral density (BMD) remains unclear. Thus, this study is aimed at exploring the association between the concentrations of serum PTH and BMD. Methods The instrumental variables for PTH were selected from a large-scale genome-wide association study (GWAS; n = 29 155). Outcomes included BMD of the forearm (FA; n = 8143), femoral neck (FN; n = 33 297), lumbar spine (LS; n = 32 735), heel (HL; n = 394 929), and risk of fractures in these bones (n = 361 194). Furthermore, the BMD of 5 different age groups: 15 years or younger (n = 11 807), 15–30 (n = 4180), 30–45 (n = 10 062), 45–60 (n = 18 805), and 60 years or older (n = 22 504) were extracted from a GWAS meta-analysis study. The analyses were performed using the 2-sample Mendelian randomization method. Results Mendelian randomization analysis revealed that the level of serum PTH was inversely associated with BMD of FA (95% CI: -0.763 to -0.016), FN (95% CI: -0.669 to -0.304), and LS (95% CI: -0.667 to -0.243). A causal relationship between serum PTH levels and BMD was observed in individuals aged 30–45 (95% CI: -0.888 to -0.166), 45–60 (95% CI: -0.758 to -0.232), and over 60 years (95% CI: -0.649 to -0.163). Main Conclusions This study demonstrated that the concentrations of serum PTH is inversely associated with BMD of several bones. Further analysis revealed site- and age-specific correlations between serum PTH levels and BMD, which implies that the levels of serum PTH contribute to the development of osteoporosis.

scholarly journals IMPACT CYP1B1 GENE POLYMORPHISM ON THE LEVEL OF BONE MINERAL DENSITY IN POSTMENOPAUSAL PERIOD IN WOMEN

2015 ◽  
pp. 35-39
Author(s):  
I. S. Zakharov ◽  
◽  
L. A. Gordeeva ◽  
G. I. Kolpinskiy ◽  
A. N. Glushkov ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Gene Polymorphism ◽  
Bone Mineral ◽  
Mineral Density ◽  
Cyp1b1 Gene ◽  
Postmenopausal Period

Hormone replacement therapy: evolution of body mass index, bone mineral density, and lipid profile

2013 ◽  
Vol 13 (2) ◽  
Author(s):  
Joaquín Cortés-Prieto ◽  
Maria Lina Vicente-Hernanz ◽  
Ana Cortés-García ◽  
Jerry Keller ◽  
Rosario Cintas del Rio ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Body Mass Index ◽  
Hormone Replacement Therapy ◽  
Lipid Profile ◽  
Replacement Therapy ◽  
Bone Mineral ◽  
Hormone Replacement ◽  
Age Groups ◽  
Mineral Density

AbstractOne hundred and eighty-five female never-hormone users with a mean age of 50.71 (SD=5.58) years upon initiation of treatment were studied before instauration and during treatment. The profile of patients subjected to the study included body mass index (BMI), bone mineral density (BMD), and lipid profile (LP). In our population, pretreatment values were within the normal range, which is why a hormone replacement therapy (HRT), conjugated equine estrogen plus medroxyprogesterone acetate, was administered to a healthy population of women for 9.82±5.42 years and follow-up comprised 1815.84 woman-years. To study the effects of treatment on the investigated clinical subjects, we resorted to comparative analyses of pretreatment and posttreatment mean values: descriptive and comparative hypothesis, followed by a repeated measurements design to investigate the evolution on three levels according to age groups just before the initiation of the treatment and on the other three levels during the treatment with a minimum follow-up of 9 years. On the basis of the numerical results, we were able to conclude that BMD decreased significantly (p=0.00) well above the values found on curves corresponding to these age groups. The total cholesterol decreased significantly at 2–3 years interval (p=0.04). The rest of the LP factors remained within a safe margin. Therefore, long-term HRT may be considered initially as a beneficial alternative in the treated study population.

scholarly journals Abdominal Obesity is Associated With Lower Bone Mineral Density in Non-Weight-Bearing Site in Korean Men

2018 ◽  
Vol 13 (1) ◽  
pp. 155798831881349 ◽  
Author(s):  
Min-Hee Kim ◽  
Sang-Wook Song ◽  
Kyung-Soo Kim
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Abdominal Obesity ◽  
Weight Bearing ◽  
Multiple Logistic Regression Analysis ◽  
Age Groups ◽  
Lower Bone Mineral Density ◽  
Mineral Density ◽  
Cross Sectional Survey ◽  
Cross Sectional

This research aimed to investigate the relationship between abdominal obesity and lower bone mineral density (BMD) at non-weight-bearing site in Korean men using data from the Korea National Health and Nutrition Examination Survey, which is a nationwide cross-sectional survey. The study population ( n = 5,941) was selected from the 2009–2010 survey. Abdominal obesity in men was defined as waist circumference ⩾ 90 cm. Lower BMD state was defined as having T-score of −2.5 or below. To investigate the association, multiple logistic regression analysis was performed. Abdominal obesity was highly associated with lower non-weight-bearing site (lumbar spine [LS]) BMD after adjustment (odds ratio [OR] 1.61, 95% CI [1.06, 2.44], p = .026). Also, abdominal obesity was a risk factor for lower LS BMD, especially in age groups of those in their 20s and those over 60s (OR 5.53, 95% CI [1.27, 24.07], p = .023 for 20s; OR 2.19, 95% CI [1.19, 4.02], p = .011 for 60 years or older). Abdominal obesity in Korean men is associated with lower BMD at non-weight-bearing site (LS), especially in younger and older age groups. Further research might be recommended to prove the mechanism or causality.

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