Synthesis and use of large peptide libraries - An overview

1999 ◽  
Author(s):  
Victor J. Hruby
Keyword(s):  
Peptide Libraries ◽  
Large Peptide

scholarly journals An in vitro polysome display system for identifying ligands from very large peptide libraries.

1994 ◽  
Vol 91 (19) ◽  
pp. 9022-9026 ◽  
Author(s):  
L. C. Mattheakis ◽  
R. R. Bhatt ◽  
W. J. Dower
Keyword(s):  
Peptide Libraries ◽  
Display System ◽  
Large Peptide

Comprehensive epitope mapping using polyclonally expanded human CD8 T cells and a two-step ELISpot assay for testing large peptide libraries

2021 ◽  
Vol 491 ◽  
pp. 112970 ◽  
Author(s):  
Clive M. Michelo ◽  
Jama A. Dalel ◽  
Peter Hayes ◽  
Natalia Fernandez ◽  
Andrew Fiore-Gartland ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Elispot Assay ◽  
Epitope Mapping ◽  
Peptide Libraries ◽  
Large Peptide

The development of organometallic OBOC peptide libraries and sequencing of N-terminal rhenium(I) tricarbonyl-containing peptides utilizing MALDI tandem mass spectrometry

2015 ◽  
Vol 93 (2) ◽  
pp. 234-243 ◽  
Author(s):  
Dana R. Cruickshank ◽  
Leonard G. Luyt
Keyword(s):  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
Systematic Investigation ◽  
Peptide Fragmentation ◽  
Peptide Libraries ◽  
Imaging Agents ◽  
Tandem Mass ◽  
Binding Properties ◽  
Fragmentation Patterns ◽  
Large Peptide

The development of peptide-based imaging agents through screening of large peptide libraries is hindered by the additional requirement of a radionuclide−chelator complex that can negatively affect the binding properties of the peptide. Herein, we report N-terminal rhenium(I)tricarbonyl OBOC (one-bead, one-compound) peptide libraries for use in the direct screening of potential imaging agents. The rhenium(I) tricarbonyl is incorporated directly in the library as an imaging entity surrogate to account for the presence of a technetium-99m radionuclide chelate. The identification of unknown organometallic peptides on single beads is successfully accomplished through MALDI tandem mass spectrometry, preceded by a systematic investigation of the effects of a variety of N-terminal rhenium(I) tricarbonyl chelates on peptide fragmentation patterns.

Preparation of Large Peptide Libraries With One Peptide per Bead and Their Use for the Discovery of Peptides That Bind to Acceptors

1993 ◽  
Author(s):  
Victor J. Hruby ◽  
◽  
Kit S. Lam ◽  
Michal Lebl ◽  
Wiesiaw Kazmierski ◽  
...  
Keyword(s):  
Peptide Libraries ◽  
Large Peptide

Latest Advances in OBOC Peptide Libraries. Improvements in Screening Strategies and Enlarging the Family From Linear to Cyclic Libraries

2016 ◽  
Vol 17 (5) ◽  
pp. 449-457 ◽  
Author(s):  
Maria C. Martínez-Ceron ◽  
Silvana L. Giudicessi ◽  
Soledad L. Saavedra ◽  
Juan M. Gurevich-Messina ◽  
Rosa Erra-Balsells ◽  
...  
Keyword(s):  
Peptide Libraries ◽  
Screening Strategies ◽  
The Family

Multiphosphorylated peptides: importance, synthetic strategies, and applications for studying biological mechanisms

2020 ◽  
Vol 18 (18) ◽  
pp. 3405-3422
Author(s):  
Mamidi Samarasimhareddy ◽  
Guy Mayer ◽  
Mattan Hurevich ◽  
Assaf Friedler
Keyword(s):  
Protein Function ◽  
Peptide Libraries ◽  
Biological Mechanisms

Advances in the synthesis of multiphosphorylated peptides and peptide libraries: tools for studying the effects of phosphorylation patterns on protein function and regulation.

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