FRI0408 Body mass index and depression are independently associated with knee pain and activity limitations in knee osteoarthritis: Results from the AMS-OA cohort

IntroductionThe authors examined how body mass index (BMI) across life is linked to the risk of midlife knee osteoarthritis (OA), testing whether prolonged exposure to high BMI or high BMI at a particular period has the greatest influence on the risk of knee OA.MethodsA population-based British birth cohort of 3035 men and women underwent clinical examination for knee OA at age 53 years.Heights and weights were measured 10 times from 2 to 53 years. Analyses were stratified by gender and adjusted for occupation and activity levels.ResultsThe prevalence of knee OA was higher in women than in men (12.9% (n=194) vs 7.4% (n=108)). In men, the association between BMI and later knee OA was evident at 20 years (p=0.038) and remained until 53 years (OR per z-score 1.38 (95% CI 1.11 to 1.71)). In women, there was evidence for an association at 15 years (p=0.003); at 53 years, the OR was 1.89 (95% CI 1.59 to 2.24) per z-score increase in BMI. Changes in BMI from childhood in women and from adolescence in men were also positively associated with knee OA. A structured modelling approach to disentange the way in which BMI is linked to knee OA suggested that prolonged exposure to high BMI throughout adulthood carried the highest risk and that there was no additional risk conferred from adolescence once adult BMI had been accounted for.ConclusionThis study suggests that the risk of knee OA accumulates from exposure to a high BMI through adulthood.

Download Full-text

Prevalence and Incidence of Hand Osteoarthritis and Upper Limb Complaints in Patients with Knee Osteoarthritis. Correlations among Functionality, Grip Strength, Changes in Body Mass Index and Symptoms among Patients in an Educational Osteoarthritis Program

Open Journal of Orthopedics ◽

10.4236/ojo.2016.61001 ◽

2016 ◽

Vol 06 (01) ◽

pp. 1-9 ◽

Cited By ~ 3

Author(s):

Vinicius Canello Kuhn ◽

Daniele dos Santos Scarcella ◽

Rosana Mayumi Suzuki ◽

Ligia Cortez de Almeida ◽

Nádia Lucila Rocha Brito ◽

...

Keyword(s):

Body Mass Index ◽

Knee Osteoarthritis ◽

Grip Strength ◽

Body Mass ◽

Upper Limb ◽

Hand Osteoarthritis

Download Full-text

Outcome Study of Non-operative Treatment for Knee Osteoarthritis in Middle-aged Patients With Reference to the Body Mass Index—A Randomised Prospective Study

Journal of Orthopaedics Trauma and Rehabilitation ◽

10.1016/j.jotr.2010.11.005 ◽

2011 ◽

Vol 15 (1) ◽

pp. 17-20 ◽

Cited By ~ 1

Author(s):

Cheong Peng Meng ◽

Ng Katherine ◽

Yan Leona ◽

Chung Jess ◽

Li Zi Ping ◽

...

Keyword(s):

Body Mass Index ◽

Knee Osteoarthritis ◽

Prospective Study ◽

Body Mass ◽

Operative Treatment ◽

The Body ◽

Outcome Study ◽

Middle Aged ◽

Aged Patients

Download Full-text

Association of trajectory of body mass index with knee pain risk in Japanese middle-aged women in a prospective cohort study: the Japan Nurses’ Health Study

BMJ Open ◽

10.1136/bmjopen-2019-033853 ◽

2020 ◽

Vol 10 (2) ◽

pp. e033853 ◽

Cited By ~ 1

Author(s):

Ayumi Ito ◽

Kunihiko Hayashi ◽

Shosuke Suzuki ◽

Yuki Ideno ◽

Takumi Kurabayashi ◽

...

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Knee Pain ◽

Primary Outcome ◽

Health Study ◽

Middle Aged ◽

Weight Group ◽

Overweight Group ◽

Bmi Trajectory

ObjectivesTo investigate whether body mass index (BMI) trajectory, lifestyle and reproductive factors are associated with knee pain risk among middle-aged women.DesignProspective study of the Japan Nurses’ Health Study (JNHS).SettingThe JNHS investigates the health of female nurses in Japan. Biennial follow-up questionnaires are mailed to the participants.ParticipantsThe 7434 women aged over 40 years who responded to the 10-year self-administered follow-up questionnaire.Primary outcome measureSelf-reported knee pain at the 10-year follow-up was the primary outcome. We analysed BMI (normal or overweight) trajectory data from a baseline survey to the 10-year follow-up survey using group-based trajectory modelling. Exposure measurements were BMI trajectory, BMI at age 18 years, lifestyle variables and reproductive history.ResultsBMI trajectories from baseline to the 10-year follow-up were divided into four groups: remained normal, remained overweight, gained weight or lost weight. At the 10-year follow-up, 1281 women (17.2%) reported knee pain. Multivariable logistic regression analysis revealed that compared with the remained normal group, multivariable-adjusted ORs (95% CI) of knee pain were 1.93 (1.60 to 2.33) for the remained overweight group, 1.60 (1.23 to 2.08) for the gained weight group and 1.40 (0.88 to 2.21) for the lost weight group. The attributable risk percent (95% CI) of the remained overweight group was 48.1% (37.3% to 57.0%) compared with the reference group of remained normal. Alcohol intake at baseline was significantly associated with knee pain.ConclusionsThe lost weight group had a lower risk than the remained overweight group and the gained weight group and did not carry statistically significant risks for knee pain. Weight reduction and maintaining a normal BMI in middle age was important for preventing knee pain in women.

Download Full-text