scholarly journals Evidence for treating rheumatoid arthritis to target: results of a systematic literature search update

2015 ◽  
Vol 75 (1) ◽  
pp. 16-22 ◽  
Author(s):  
Michaela A Stoffer ◽  
Monika M Schoels ◽  
Josef S Smolen ◽  
Daniel Aletaha ◽  
Ferdinand C Breedveld ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Literature Search ◽  
Systematic Literature Search

scholarly journals Safety and efficiency of therapy by gene-engineering-biological preparations of rheumatoid arthritis

2018 ◽  
Vol 9 (3) ◽  
pp. 44-49
Author(s):  
E. A. Strel’tsov
Keyword(s):  
Rheumatoid Arthritis ◽  
Literature Search ◽  
Randomized Trials ◽  
Web Of Science ◽  
Genetically Engineered ◽  
Systematic Literature Search ◽  
Efficacy And Safety ◽  
Review Of The Literature ◽  
Gene Engineering

In this review of the literature, questions of the efficacy and safety of therapy with genetically engineered biological preparations for rheumatoid arthritis are discussed. The results of randomized trials of recent years are described in detail. Systematic literature search was conducted on the databases Scopus, Web of Science, MedLine, elibrary and others.

Predictors of Clinical Response and Radiographic Progression in Patients with Rheumatoid Arthritis Treated with Methotrexate Monotherapy

2010 ◽  
Vol 37 (7) ◽  
pp. 1405-1410 ◽  
Author(s):  
JULIE DROUIN ◽  
BOULOS HARAOUI
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Clinical Response ◽  
Literature Search ◽  
Radiographic Progression ◽  
Statistical Tests ◽  
Patient Characteristics ◽  
Cochrane Central Register ◽  
Systematic Literature Search ◽  
American College Of Rheumatology

Objective.To determine through a systematic literature search the predictors of clinical response and radiographic progression in adult patients with rheumatoid arthritis (RA) treated with methotrexate (MTX) monotherapy.Methods.A systematic literature search using Medline, Embase, and the Cochrane Central Register of Controlled Trials, in May 2008, and review of abstracts of the annual congresses of the American College of Rheumatology (2006–2007) and the European League Against Rheumatism (2002–2007) was performed, as part of a national initiative to develop guidelines for the use of MTX in RA.Results.Nine studies fulfilled the criteria set for this literature search. Male sex, low disease activity measured by composite scores (DAS or SDAI), and nonutilization of prior DMARD were predictive of good clinical response to MTX. Patients with early RA who are rheumatoid factor-positive and smokers tend to have lower response. However, this last association has not been found for patients with established disease. High disease activity before introduction of MTX monotherapy and higher activity during followup at 3 months is a predictor of more severe radiographic progression.Conclusion.Among factors found to be predictive of clinical and radiographic outcomes of patients with RA treated with MTX, no factor was found to have a high predictive value. Variability in efficacy measures and statistical tests made it difficult to compare results. Followup of disease activity after 3 to 6 months of treatment seems to be a better and more useful predictor than baseline patient characteristics.

Testing of the OMERACT 8 Draft Validation Criteria for a Soluble Biomarker Reflecting Structural Damage in Rheumatoid Arthritis: A Systematic Literature Search on 5 Candidate Biomarkers

2009 ◽  
Vol 36 (8) ◽  
pp. 1769-1784 ◽  
Author(s):  
SILJE W. SYVERSEN ◽  
ROBERT LANDEWE ◽  
DÉSIRÉE van der HEIJDE ◽  
JOAN M. BATHON ◽  
MAARTEN BOERS ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Structural Damage ◽  
Animal Studies ◽  
Literature Search ◽  
Rating Scale ◽  
Numerical Rating Scale ◽  
Systematic Literature Search ◽  
Strength Of Evidence ◽  
Validation Criteria ◽  
Individual Criterion

Objective.To test the OMERACT 8 draft validation criteria for soluble biomarkers by assessing the strength of literature evidence in support of 5 candidate biomarkers.Methods.A systematic literature search was conducted on the 5 soluble biomarkers RANKL, osteoprotegerin (OPG), matrix metalloprotease (MMP-3), urine C-telopeptide of types I and II collagen (U-CTX-I and U CTX-II), focusing on the 14 OMERACT 8 criteria. Two electronic voting exercises were conducted to address: (1) strength of evidence for each biomarker as reflecting structural damage according to each individual criterion and the importance of each individual criterion; (2) overall strength of evidence in support of each of the 5 candidate biomarkers as reflecting structural damage endpoints in rheumatoid arthritis (RA) and identification of omissions to the criteria set.Results.The search identified 111 articles. The strength of evidence in support of these biomarkers reflecting structural damage was low for all biomarkers and was rated highest for U-CTX-II [score of 6.5 (numerical rating scale 0–10)]. The lowest scores for retention of specific criteria in the draft set went to criteria that refer to the importance of animal studies, correlations with other biomarkers reflecting damage, and an understanding of the metabolism of the biomarker.Conclusion.Evidence in support of any of the 5 tested biomarkers (MMP-3, CTX-I, CTX-II, OPG, RANKL) was inadequate to allow their substitution for radiographic endpoints in RA. Three of the criteria in the draft criteria set might not be required, but few omissions were identified.

scholarly journals Evidence for treating rheumatoid arthritis to target: results of a systematic literature search

2010 ◽  
Vol 69 (4) ◽  
pp. 638-643 ◽  
Author(s):  
M. Schoels ◽  
R. Knevel ◽  
D. Aletaha ◽  
J. W. J. Bijlsma ◽  
F. C. Breedveld ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Literature Search ◽  
Systematic Literature Search

scholarly journals bDMARD Dose Reduction in Rheumatoid Arthritis: A Narrative Review with Systematic Literature Search

2017 ◽  
Vol 4 (1) ◽  
pp. 1-24 ◽  
Author(s):  
Lise M. Verhoef ◽  
Lieke Tweehuysen ◽  
Marlies E. Hulscher ◽  
Bruno Fautrel ◽  
Alfons A. den Broeder
Keyword(s):  
Rheumatoid Arthritis ◽  
Dose Reduction ◽  
Literature Search ◽  
Narrative Review ◽  
Systematic Literature Search

scholarly journals Evidence for treating rheumatoid arthritis to target: results of a systematic literature search update

2016 ◽  
Vol 75 (7) ◽  
pp. e35-e35 ◽  
Author(s):  
Rudra Prosad Goswami ◽  
Kaushik Basu ◽  
Shyamashis Das ◽  
Sumantro Mondal ◽  
Parasar Ghosh ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Literature Search ◽  
Systematic Literature Search

Associations of coronary and peripheral artery disease with presence, expansion, and rupture of abdominal aortic aneurysm – a grin without a cat!

VASA ◽  
2017 ◽  
Vol 46 (3) ◽  
pp. 151-158 ◽  
Author(s):  
Hisato Takagi ◽  
Takuya Umemoto
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Peripheral Artery Disease ◽  
Literature Search ◽  
Systematic Literature Search ◽  
Peripheral Artery ◽  
Epidemiological Evidence ◽  
Abdominal Aortic ◽  
Artery Disease ◽  
Meta Analyses

Abstract. Both coronary and peripheral artery disease are representative atherosclerotic diseases, which are also known to be positively associated with presence of abdominal aortic aneurysm. It is still controversial, however, whether coronary and peripheral artery disease are positively associated with expansion and rupture as well as presence of abdominal aortic aneurysm. In the present article, we overviewed epidemiological evidence, i. e. meta-analyses, regarding the associations of coronary and peripheral artery disease with presence, expansion, and rupture of abdominal aortic aneurysm through a systematic literature search. Our exhaustive search identified seven meta-analyses, which suggest that both coronary and peripheral artery disease are positively associated with presence of abdominal aortic aneurysm, may be negatively associated with expansion of abdominal aortic aneurysm, and might be unassociated with rupture of abdominal aortic aneurysm.

Wrist Arthrolysis: A Systematic Review of Open and Arthroscopic Techniques

2021 ◽  
Author(s):  
Marco Guidi ◽  
Riccardo Luchetti ◽  
Inga Besmens ◽  
Esin Rothenfluh ◽  
Maurizio Calcagni
Keyword(s):  
Systematic Review ◽  
Literature Search ◽  
Systematic Literature Search ◽  
Viable Option ◽  
Level Of Evidence ◽  
Open Arthrolysis ◽  
Arthroscopic Arthrolysis ◽  
Radiocarpal Joint ◽  
Post Traumatic ◽  
Wrist Stiffness

Abstract Background Wrist arthrolysis is a viable option in wrist stiffness and can be performed via open or arthroscopic techniques. Purpose The aim of the study is to describe and evaluate the available techniques of open and arthroscopic arthrolysis of the radiocarpal joint and the distal radio ulnar joint (DRUJ) in posttraumatic wrist stiffness. Methods A systematic literature search was performed in PubMed to identify studies reporting on open and arthroscopic wrist arthrolysis. Key words included “open wrist arthrolysis,” “arthroscopic wrist arthrolysis,” “post-traumatic wrist stiffness,” and “DRUJ arthrolysis.” Data were extracted independently by a pair of reviewers. Results Overall, 637 studies were identified; 13 additional articles were found through previous publications (total 650 articles). A total of 612 records resulted after duplicates was removed. Fourteen studies were selected and only eight respected the inclusions criteria. One study focused on volar open arthrolysis and four studies on arthroscopic arthrolysis of the radiocarpal joint; two studies reported on open arthrolysis and two studies on arthroscopic DRUJ arthrolysis. Range of motion following open and arthroscopic wrist arthrolysis improved in all studies. Conclusion Both arthroscopic and open arthrolysis can lead to similar and satisfactory results in radiocarpal joint and DRUJ stiffness.. Level of Evidence This is a level 3a study.

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