SAT0123 Evidence-Based Recommendations for the Management of Comorbidities in Rheumatoid Arthritis, Psoriasis and Psoriatic Arthritis: A Systematic Literature Search and Expert Opinion

2014 ◽  
Vol 73 (Suppl 2) ◽  
pp. 635.1-635
Author(s):  
C. Roubille ◽  
V. Richer ◽  
T. Starnino ◽  
C. McCourt ◽  
A. McFarlane ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Psoriatic Arthritis ◽  
Expert Opinion ◽  
Literature Search ◽  
Evidence Based ◽  
Systematic Literature Search

scholarly journals Safety and efficiency of therapy by gene-engineering-biological preparations of rheumatoid arthritis

2018 ◽  
Vol 9 (3) ◽  
pp. 44-49
Author(s):  
E. A. Strel’tsov
Keyword(s):  
Rheumatoid Arthritis ◽  
Literature Search ◽  
Randomized Trials ◽  
Web Of Science ◽  
Genetically Engineered ◽  
Systematic Literature Search ◽  
Efficacy And Safety ◽  
Review Of The Literature ◽  
Gene Engineering

In this review of the literature, questions of the efficacy and safety of therapy with genetically engineered biological preparations for rheumatoid arthritis are discussed. The results of randomized trials of recent years are described in detail. Systematic literature search was conducted on the databases Scopus, Web of Science, MedLine, elibrary and others.

scholarly journals Evidence for treating rheumatoid arthritis to target: results of a systematic literature search update

2015 ◽  
Vol 75 (1) ◽  
pp. 16-22 ◽  
Author(s):  
Michaela A Stoffer ◽  
Monika M Schoels ◽  
Josef S Smolen ◽  
Daniel Aletaha ◽  
Ferdinand C Breedveld ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Literature Search ◽  
Systematic Literature Search

Predictors of Clinical Response and Radiographic Progression in Patients with Rheumatoid Arthritis Treated with Methotrexate Monotherapy

2010 ◽  
Vol 37 (7) ◽  
pp. 1405-1410 ◽  
Author(s):  
JULIE DROUIN ◽  
BOULOS HARAOUI
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Clinical Response ◽  
Literature Search ◽  
Radiographic Progression ◽  
Statistical Tests ◽  
Patient Characteristics ◽  
Cochrane Central Register ◽  
Systematic Literature Search ◽  
American College Of Rheumatology

Objective.To determine through a systematic literature search the predictors of clinical response and radiographic progression in adult patients with rheumatoid arthritis (RA) treated with methotrexate (MTX) monotherapy.Methods.A systematic literature search using Medline, Embase, and the Cochrane Central Register of Controlled Trials, in May 2008, and review of abstracts of the annual congresses of the American College of Rheumatology (2006–2007) and the European League Against Rheumatism (2002–2007) was performed, as part of a national initiative to develop guidelines for the use of MTX in RA.Results.Nine studies fulfilled the criteria set for this literature search. Male sex, low disease activity measured by composite scores (DAS or SDAI), and nonutilization of prior DMARD were predictive of good clinical response to MTX. Patients with early RA who are rheumatoid factor-positive and smokers tend to have lower response. However, this last association has not been found for patients with established disease. High disease activity before introduction of MTX monotherapy and higher activity during followup at 3 months is a predictor of more severe radiographic progression.Conclusion.Among factors found to be predictive of clinical and radiographic outcomes of patients with RA treated with MTX, no factor was found to have a high predictive value. Variability in efficacy measures and statistical tests made it difficult to compare results. Followup of disease activity after 3 to 6 months of treatment seems to be a better and more useful predictor than baseline patient characteristics.

Testing of the OMERACT 8 Draft Validation Criteria for a Soluble Biomarker Reflecting Structural Damage in Rheumatoid Arthritis: A Systematic Literature Search on 5 Candidate Biomarkers

2009 ◽  
Vol 36 (8) ◽  
pp. 1769-1784 ◽  
Author(s):  
SILJE W. SYVERSEN ◽  
ROBERT LANDEWE ◽  
DÉSIRÉE van der HEIJDE ◽  
JOAN M. BATHON ◽  
MAARTEN BOERS ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Structural Damage ◽  
Animal Studies ◽  
Literature Search ◽  
Rating Scale ◽  
Numerical Rating Scale ◽  
Systematic Literature Search ◽  
Strength Of Evidence ◽  
Validation Criteria ◽  
Individual Criterion

Objective.To test the OMERACT 8 draft validation criteria for soluble biomarkers by assessing the strength of literature evidence in support of 5 candidate biomarkers.Methods.A systematic literature search was conducted on the 5 soluble biomarkers RANKL, osteoprotegerin (OPG), matrix metalloprotease (MMP-3), urine C-telopeptide of types I and II collagen (U-CTX-I and U CTX-II), focusing on the 14 OMERACT 8 criteria. Two electronic voting exercises were conducted to address: (1) strength of evidence for each biomarker as reflecting structural damage according to each individual criterion and the importance of each individual criterion; (2) overall strength of evidence in support of each of the 5 candidate biomarkers as reflecting structural damage endpoints in rheumatoid arthritis (RA) and identification of omissions to the criteria set.Results.The search identified 111 articles. The strength of evidence in support of these biomarkers reflecting structural damage was low for all biomarkers and was rated highest for U-CTX-II [score of 6.5 (numerical rating scale 0–10)]. The lowest scores for retention of specific criteria in the draft set went to criteria that refer to the importance of animal studies, correlations with other biomarkers reflecting damage, and an understanding of the metabolism of the biomarker.Conclusion.Evidence in support of any of the 5 tested biomarkers (MMP-3, CTX-I, CTX-II, OPG, RANKL) was inadequate to allow their substitution for radiographic endpoints in RA. Three of the criteria in the draft criteria set might not be required, but few omissions were identified.

Stump management after trans-tibial amputation: A systematic review

2005 ◽  
Vol 29 (1) ◽  
pp. 13-26 ◽  
Author(s):  
S. E. Nawijn ◽  
H. van der Linde ◽  
C. H. Emmelot ◽  
C. J. Hofstad
Keyword(s):  
Functional Outcome ◽  
Methodological Quality ◽  
Literature Search ◽  
Weight Bearing ◽  
Relevant Literature ◽  
Evidence Based ◽  
Systematic Literature Search ◽  
Large Variability ◽  
Early Weight Bearing

In order to achieve stump healing after trans-tibial amputation, various methods are applied, such as soft dressings followed by elastic wrapping of the stump, rigid dressings, semi-rigid dressings, and more recently the application of silicon or gel-liners. A systematic literature search was performed to identify the optimal post-amputation management. The methodological quality of the studies was systematically evaluated by using a predefined list of criteria. Only 11 controlled studies were identified and evaluated for their methodological quality. From these studies, no studies were classified as A-level studies, whereas three were classified as B-level, and 8 were classified as C-level studies. Relevant literature appears heterogeneous with respect to patient selection, intervention and outcome measures. Despite the large variability of included studies, this review reveals a trend in favour of rigid and semi-rigid dressings for achieving stump healing and reduction of stump volume. No conclusions can be drawn with regard to the effect on functional outcome. The literature is not conclusive on the effects of early weight bearing on stump healing, volume reduction, and functional outcome. More research is needed for the development of evidence-based clinical practice guidelines concerning management after trans-tibial amputation.

scholarly journals Evidence-based Recommendations for the Management of Comorbidities in Rheumatoid Arthritis, Psoriasis, and Psoriatic Arthritis: Expert Opinion of the Canadian Dermatology-Rheumatology Comorbidity Initiative

2015 ◽  
Vol 42 (10) ◽  
pp. 1767-1780 ◽  
Author(s):  
Camille Roubille ◽  
Vincent Richer ◽  
Tara Starnino ◽  
Collette McCourt ◽  
Alexandra McFarlane ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Practice ◽  
Psoriatic Arthritis ◽  
Potential Effect ◽  
Cochrane Library ◽  
Evidence Based ◽  
Grade Of Recommendation ◽  
The Cochrane Library ◽  
Based Medicine ◽  
Level Of Agreement

Objective.Comorbidities such as cardiovascular diseases (CVD), cancer, osteoporosis, and depression are often underrecognized in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), or psoriasis (PsO). Recommendations may improve identification and treatment of comorbidities. The Canadian Dermatology-Rheumatology Comorbidity Initiative reviewed the literature to develop practical evidence-based recommendations for management of comorbidities in patients with RA, PsA, and PsO.Methods.Eight main topics regarding comorbidities in RA, PsA, and PsO were developed. MEDLINE, EMBASE, and the Cochrane Library (1960–12/2012), together with abstracts from major rheumatology and dermatology congresses (2010–2012), were searched for relevant publications. Selected articles were analyzed and metaanalyses performed whenever possible. A meeting including rheumatologists, dermatologists, trainees/fellows, and invited experts was held to develop consensus-based recommendations using a Delphi process with prespecified cutoff agreement. Level of agreement was measured using a 10-point Likert scale (1 = no agreement, 10 = full agreement) and the potential effect of recommendations on daily clinical practice was considered. Grade of recommendation (ranging from A to D) was determined according to the Oxford Centre for Evidence-Based Medicine evidence levels.Results.A total of 17,575 articles were identified, of which 407 were reviewed. Recommendations were synthesized into 19 final recommendations ranging mainly from grade C to D, and relating to a large spectrum of comorbidities observed in clinical practice: CVD, obesity, osteoporosis, depression, infections, and cancer. Level of agreement ranged from 80.9% to 95.8%.Conclusion.These practical evidence-based recommendations can guide management of comorbidities in patients with RA, PsA, and PsO and optimize outcomes.

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