AB0093 Efficacy of Radiation Synovectomy (Radiosynovectomy or Radiosynoviorthesis) with Yttrium-90 (Y-90) in Exudative Inflammation of Synovial Membrane of Knee Joints in Patients with Rheumatic Diseases:

2015 ◽  
Vol 74 (Suppl 2) ◽  
pp. 921.3-922
Author(s):  
J. Zalewska ◽  
I. Dankiewicz-Fares ◽  
R. Wojciechowski ◽  
S. Jeka
Keyword(s):  
Rheumatic Diseases ◽  
Synovial Membrane ◽  
Knee Joints ◽  
Radiation Synovectomy ◽  
Yttrium 90

Symptomatic osteonecrosis of the hip and knee in patients with systemic lupus erythematosus: Prevalence, pattern, and comparison of natural course

Lupus ◽  
2021 ◽  
pp. 096120332110310
Author(s):  
Mehmet Ersin ◽  
Mehmet Demirel ◽  
Mehmet Ekinci ◽  
Lezgin Mert ◽  
Çiğdem Çetin ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Rheumatic Diseases ◽  
Lupus Erythematosus ◽  
Bone Structure ◽  
Survival Rates ◽  
Knee Joints ◽  
Joint Involvement ◽  
Systemic Lupus ◽  
Kaplan Meier ◽  
The Mean

Objective Osteonecrosis (ON), also known as avascular necrosis, is characterized by the collapse of the architectural bone structure secondary to the death of the bone marrow and trabecular bone. Osteonecrosis may accompany many conditions, especially rheumatic diseases. Among rheumatic diseases, osteonecrosis is most commonly associated with systemic lupus erythematosus (SLE). We assessed prevalence and distribution pattern of symptomatic ON in patients with SLE and compare the natural courses of hip and knee ON. Methods 912 SLE patients admitted between 1981 and 2012 were reviewed. SLE patients with symptomatic ON were retrospectively identified both from the existing SLE/APS database. The prevalence of symptomatic ON was calculated; with ON, the joint involvement pattern was determined by examining the distribution of the joints involved, and then the data about the hip and knee joints were entered in the Kaplan-Meier analysis. Kaplan-Meier methods were used to calculate 5- and 10-year rates of ON-related hip (the hip group) and knee survival (the knee group). Results Symptomatic ON developed in various joints in 97 of 912 patients with SLE, and the overall prevalence of ON was detected as 10.6%. The mean age at the time of SLE and ON diagnoses were 27.9 ± 9.9 (14–53) and 34.2 ± 11.3 (16–62) years, respectively. The mean duration from diagnosis of SLE to the first development of ON was 70.7± 60.2 (range = 0–216) months. The most common site for symptomatic ON was the hips (68%, n=66), followed by the knees (38%, n = 37). According to Kaplan-Meier analysis, hip and knee joint survival rates associated with 5-year ON were 51% and 88%, and 10-year survival rates were 43% and 84%, respectively. Conclusion We observed that the prevalence of symptomatic ON in patients with SLE was 10.6%. With the estimated 10-year survival rates of 40% versus 84% for the hip and knee joints, respectively, hip involvement may demonstrate a more aggressive course to end-stage osteoarthritis than the knee involvement.

scholarly journals Dosimetric evaluation in radiation synovectomy

2005 ◽  
Vol 48 (spe2) ◽  
pp. 153-158 ◽  
Author(s):  
Carla Flávia de Lima ◽  
Tarcisio Passos Ribeiro de Campo
Keyword(s):  
Rheumatoid Arthritis ◽  
Articular Cartilage ◽  
Synovial Membrane ◽  
Half Life ◽  
Three Dimensional ◽  
Low Energy ◽  
Radioactive Material ◽  
Radiation Synovectomy ◽  
Voxel Model ◽  
The Common

Rheumatoid arthritis can manifest itself through synovitis, of which the knee is the common locale. The treatment using an intra-articular radioisotope injection has been applied in various countries. In this work, the dose of radioactive material absorbed in the joint is evaluated, taking into consideration the dose received in the articular cartilage and adjacencies using a three-dimensional voxel model representing the knee. The radioisotopes studied were Samarium-153 and Dysprosium-165. The results show that the synovial membrane receives 85 to 98% of the normalized dose taken from all voxels representative of the synovium. The following features of 153Sm and of 165Dy - its short physical half-life, the gamma emissions with low energy which allow monitoring the injection trough scintigraphy images, the possibility of binding themselves to macroaggregates that are retained in the joint, the high percentage of the effective dose spread in the synovial membrane - make these suitable radioisotopes for radiation synovectomy.

Yttrium-90 radiation synovectomy in knee osteoarthritis: a prospective assessment at 6 and 12 months

2009 ◽  
Vol 30 (6) ◽  
pp. 472-479 ◽  
Author(s):  
Dimitrios Chatzopoulos ◽  
Efstratios Moralidis ◽  
Pavlos Markou ◽  
Vassilios Makris
Keyword(s):  
Knee Osteoarthritis ◽  
Radiation Synovectomy ◽  
Prospective Assessment ◽  
Yttrium 90

Vascularization of the Synovial Membrane in Hemophilic Synovitis.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 4018-4018
Author(s):  
Ramona McClain ◽  
Narine Hakobyan ◽  
Leonard A. Valentino
Keyword(s):  
Synovial Membrane ◽  
Direct Relationship ◽  
Severe Disease ◽  
Coagulation Factor ◽  
Synovial Fibroblasts ◽  
Trophic Factors ◽  
Knee Joints ◽  
Surgical Trauma ◽  
Experimental Conditions ◽  
Adolescents And Adults

Abstract Hemophilia is due to the deficiency of the activity of coagulation factor VIII or IX and results in bleeding. Hemarthrosis frequently leads to synovitis and arthropathy in adolescents and adults with severe disease. The molecular basis for this disorder is only recently being interrogated in detail (Wen, Jabbar et al. 2002; Hakobyan, Kazarian et al. 2004; Valentino, Hakobyan et al. 2004; Hakobyan, Kazarian et al. 2005). In addition to proliferation of synovial fibroblasts, vessels are prominent and likely play a fundamental role. We hypothesized that synovial hyperplasia was limited by the degree of tissue vascularization and a direct relationship between the expansions of these two tissues existed. To test this hypothesis, mouse knee joints were injured by blunt or surgical trauma to induce hemarthrosis or blood was directly injected into the joint capsule to induce synovitis then the knees isolated and the tissues examined by seven reviewers blinded to the experimental conditions for the extent of synovial and vessel hyperplasia (Valentino and Hakobyan 2006, in press) and their individual scores averaged. The distribution of the scores for the 271 sections is given in the table. A direct relationship (r2=0.90, p<0.001) between synovial and vessel hyperplasia was present (figure). It is likely that the synovial membrane can expand up to a point (grade 1) but beyond this, vessel hyperplasia is necessary and that progressive hypertrophy of the synovial membrane is dependent upon the development of vessels to provide oxygen and nutrients. The production of vascular trophic factors by synovial fibroblast cells is under investigation. Types and numbers of hyperplasia Hyperplasia 0 1 2 3 Synovial 149 67 18 37 Vascular 180 58 19 14 Figure Figure

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