scholarly journals THU0148 Increase of night qt-interval duration in rheumatoid arthritis patients treated with tofacitinib during 12-month follow-up

2017 ◽  
Author(s):  
IG Kirillova ◽  
D Novikova ◽  
E Luchikhina ◽  
E Markelova ◽  
H Udachkina ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Qt Interval ◽  
Interval Duration ◽  
Qt Interval Duration

scholarly journals Normal and abnormal QT interval duration and its changes in preadolescents and adolescents practicing sport

EP Europace ◽  
2019 ◽  
Vol 21 (10) ◽  
pp. 1566-1574 ◽  
Author(s):  
Flavio D’Ascenzi ◽  
Francesca Anselmi ◽  
Francesca Graziano ◽  
Beatrice Berti ◽  
Andrea Franchini ◽  
...  
Keyword(s):  
Qt Interval ◽  
Qtc Interval ◽  
Interval Duration ◽  
Prospective Longitudinal Study ◽  
Repolarization Phase ◽  
Life Threatening ◽  
Qt Interval Duration ◽  
Electrocardiogram Ecg ◽  
Prospective Longitudinal

Abstract Aims Twelve-lead electrocardiogram (ECG) is an established tool in the evaluation of athletes, providing information about life-threatening cardiovascular diseases, such as long QT syndrome. However, the interpretation of ECG is sometimes challenging in children, particularly for the repolarization phase. The aim of this prospective, longitudinal study was to determinate the distribution of QT interval in children practicing sport and to evaluate changes in QT duration overtime. Methods and results A population of 1473 preadolescents practising sport (12.0 ± 1.8 years, 7–15 years) was analysed. Each athlete was evaluated at baseline, mid-term, and end of the study (mean follow-up: 3 ± 1 years). QT interval was corrected with Bazett (B) and Fridericia (F) formulae. At baseline QT interval corrected with the Bazett formula (QTcB) was 412 ± 25 ms and QT interval corrected with the Fridericia formula (QTcF) 387 ± 21 ms, with no changes during follow-up. Ten children (0.68%) had an abnormal QTc. In those with QTcB and QTcF ≥480 ms, QTc duration persisted abnormal during the follow-up and they were disqualified. Conversely, children with 460 ms < (QTcB) <480 ms had a normal QTc interval at the end of the study. These children had also a normal QTcF. Mean difference in the calculation of QT between the two formulae was 25 ± 11 ms (P < 0.0001). For resting heart rate (HR) ≥82 b.p.m., QTcF was independent from HR contrary to QTcB. Conclusion Normal QTc interval does not change over time in preadolescents. A minority of them has a QTc ≥480 ms; in these subjects, QTc interval remains prolonged. The use of Bazett and Fridericia correction formulae is not interchangeable and the Fridericia correction should be preferred in preadolescents with a resting HR ≥82 b.p.m.

scholarly journals Coffee, Alcohol, Smoking, Physical Activity and QT Interval Duration: Results from the Third National Health and Nutrition Examination Survey

PLoS ONE ◽  
2011 ◽  
Vol 6 (2) ◽  
pp. e17584 ◽  
Author(s):  
Yiyi Zhang ◽  
Wendy S. Post ◽  
Darshan Dalal ◽  
Elena Blasco-Colmenares ◽  
Gordon F. Tomaselli ◽  
...  
Keyword(s):  
Physical Activity ◽  
National Health ◽  
Qt Interval ◽  
Nutrition Examination Survey ◽  
Interval Duration ◽  
The Third ◽  
Health And Nutrition ◽  
Qt Interval Duration

scholarly journals Complex Influence of Gonadotropins and Sex Steroid Hormones on QT Interval Duration

2016 ◽  
Vol 101 (7) ◽  
pp. 2776-2784 ◽  
Author(s):  
Guillaume Abehsira ◽  
Anne Bachelot ◽  
Fabio Badilini ◽  
Laurence Koehl ◽  
Martine Lebot ◽  
...  
Keyword(s):  
Steroid Hormones ◽  
Qt Interval ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
Interval Duration ◽  
Qt Interval Duration ◽  
Complex Influence

Abstract 2924: Association of NOS1AP Genetic Variants with QT Interval Duration in Families from the Diabetes Heart Study

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Allison B Lehtinen ◽  
Christopher Newton-Cheh ◽  
Julie T Ziegler ◽  
Carl D Langefeld ◽  
Barry I Freedman ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Qt Interval ◽  
Genetic Model ◽  
Additive Model ◽  
Adaptor Protein ◽  
European Ancestry ◽  
Nucleotide Polymorphisms ◽  
Interval Duration ◽  
Common Genetic Variants ◽  
Qt Interval Duration

Background: Prolongation of the electrocardiographic QT interval is a risk factor for sudden cardiac death (SCD) in unselected samples as well as in post-myocardial infarction patients or those with diabetes. Common genetic variants in the nitric oxide synthase 1 adaptor protein (NOS1AP) gene have been reported to be associated with QT interval duration in individuals of European ancestry. We sought to replicate the association of NOS1AP variants with QT interval duration in pedigrees enriched for type 2 diabetes mellitus (T2DM). Methods and Results: Two single nucleotide polymorphisms (SNPs) in the NOS1AP gene, rs10494366 and rs10918594, were genotyped in a collection of 937 European Americans (EAs) and 177 African Americans (AAs) in 450 pedigrees containing at least two siblings with T2DM. An additive genetic model was tested for each SNP in ancestry-specific analyses using SOLAR in the total sample and in the diabetic subset (EA n=778, AA n=159), with and without exclusion of QT-altering medications. In the EA individuals, rs10494366 minor allele homozygotes had an 8.9 msec longer mean QT interval compared to major homozygotes (additive model p=4.4x10 -3 ); rs10918594 minor homozygotes had a 12.9 msec longer mean QT interval compared to major homozygotes (p=9.9x10 -5 ). Excluding users of QT-altering medications in the diabetic-only EA sample (n=514) strengthened the association despite the reduction in sample size (20.6 msec difference, p=2.0x10 -5 ; 23.4 msec difference, p=8.9x10 -7 , respectively). No association between the NOS1AP SNPs and QT interval duration was observed in the limited number of AA individuals examined. Conclusions: Two NOS1AP SNPs are strongly associated with QT interval duration in a predominately diabetic EA sample. Stronger effects of NOS1AP variants in diabetic individuals compared to previously reported unselected samples suggest that this patient subset may be particularly susceptible to genetic variants that influence myocardial depolarization and repolarization as manifest in the QT interval.

scholarly journals Heart Rate–corrected QT Interval Duration in Rheumatoid Arthritis and Its Reduction with Treatment with the Interleukin 6 Inhibitor Tocilizumab

2018 ◽  
Vol 45 (12) ◽  
pp. 1620-1627 ◽  
Author(s):  
Hitomi Kobayashi ◽  
Yasuyuki Kobayashi ◽  
Isamu Yokoe ◽  
Noboru Kitamura ◽  
Atsuma Nishiwaki ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Interleukin 6 ◽  
Qt Interval ◽  
Cardiac Repolarization ◽  
Matrix Metalloproteinase 3 ◽  
Reactive Protein ◽  
Response Measures ◽  
Qt Interval Duration ◽  
Citrullinated Peptide ◽  
Repolarization Abnormalities

Objective.Individuals with rheumatoid arthritis (RA) are at a heightened risk of sudden cardiac death, an outcome increased in those with prolongation of the corrected electrocardiographic QT interval (QTc). We compared QTc between patients with RA and demographically matched controls and studied the change in QTc after treatment with the interleukin 6 inhibitor tocilizumab (TCZ).Methods.Standard 12-lead electrocardiograms were obtained and QTc was measured in patients with RA at baseline and after 24 weeks of TCZ treatment, then compared with non-RA controls who were frequency-matched on age and sex. Indicators of the baseline QTc and predictors of change in QTc were studied using multivariable linear regression.Results.A total of 94 RA and 42 non-RA controls were studied. The average baseline QTc was 10 ms longer in the RA group vs controls (422 vs 412 ms, respectively; p < 0.001) and decreased to an average of 406 ms with treatment (p < 0.001). Baseline QTc was significantly and independently higher among those with anticyclic citrullinated peptide antibodies seropositivity, higher swollen joint counts, and higher levels of C-reactive protein (CRP) and matrix metalloproteinase 3. Each log unit decrease in CRP with treatment was associated with an average reduction in QTc of 2.9 ms (p = 0.002) after adjusting for age and baseline QTc. Clinical response measures were not associated with the change in QTc.Conclusion.The marked normalization of QTc observed with TCZ treatment, and its close parallel with CRP reduction, support the premise that systemic inflammation contributes to cardiac repolarization abnormalities in RA that may be amenable to treatment.

Physical Activity, BMI and Smoking History Affect QT Interval Duration in Cardiac Patients

2014 ◽  
Vol 25 (1) ◽  
pp. 4
Author(s):  
C. J. Brahler ◽  
H. Merriman ◽  
S. Price ◽  
M. Duncan ◽  
A. Pertner ◽  
...  
Keyword(s):  
Physical Activity ◽  
Qt Interval ◽  
Cardiac Patients ◽  
Smoking History ◽  
Interval Duration ◽  
Qt Interval Duration
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