scholarly journals P113/O17 Human lymph node stromal cells express self-antigens targeted by anti-citrullinated protein antybodies: role for tolerance induction in rheumathoid arthritis

2019 ◽  
Author(s):  
C Grasso ◽  
JS Hähnlein ◽  
R Nadafi ◽  
TA De Jong ◽  
TH Ramwadhdoebe ◽  
...  
Keyword(s):  
Lymph Node ◽  
Stromal Cells ◽  
Tolerance Induction ◽  
Human Lymph Node ◽  
Citrullinated Protein ◽  
Lymph Node Stromal Cells ◽  
Self Antigens

scholarly journals Molecular Characterization of Human Lymph Node Stromal Cells During the Earliest Phases of Rheumatoid Arthritis

2019 ◽  
Vol 10 ◽  
Author(s):  
Emmanuel Karouzakis ◽  
Janine Hähnlein ◽  
Cristoforo Grasso ◽  
Johanna F. Semmelink ◽  
Paul P. Tak ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Lymph Node ◽  
Molecular Characterization ◽  
Stromal Cells ◽  
Human Lymph Node ◽  
Lymph Node Stromal Cells

A8.17 Expression of the autoimmune regulator aire in human lymph node stromal cells

2014 ◽  
Vol 73 (Suppl 1) ◽  
pp. A82.3-A83 ◽  
Author(s):  
J Hähnlein ◽  
T H Ramwadhdoebe ◽  
J F Semmelink ◽  
K I Maijer ◽  
I. Y. Choi ◽  
...  
Keyword(s):  
Lymph Node ◽  
Stromal Cells ◽  
Autoimmune Regulator ◽  
Human Lymph Node ◽  
Lymph Node Stromal Cells

scholarly journals Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
Antonio P Baptista ◽  
Ramon Roozendaal ◽  
Rogier M Reijmers ◽  
Jasper J Koning ◽  
Wendy W Unger ◽  
...  
Keyword(s):  
T Cells ◽  
Lymph Node ◽  
Antigen Presentation ◽  
Mhc Class Ii ◽  
Cd8 T Cells ◽  
Stromal Cells ◽  
Transplant Rejection ◽  
Mhc Ii ◽  
Self Antigen ◽  
Lymph Node Stromal Cells

Non-hematopoietic lymph node stromal cells shape immunity by inducing MHC-I-dependent deletion of self-reactive CD8+ T cells and MHC-II-dependent anergy of CD4+ T cells. In this study, we show that MHC-II expression on lymph node stromal cells is additionally required for homeostatic maintenance of regulatory T cells (Tregs) and maintenance of immune quiescence. In the absence of MHC-II expression in lymph node transplants, i.e. on lymph node stromal cells, CD4+ as well as CD8+ T cells became activated, ultimately resulting in transplant rejection. MHC-II self-antigen presentation by lymph node stromal cells allowed the non-proliferative maintenance of antigen-specific Tregs and constrained antigen-specific immunity. Altogether, our results reveal a novel mechanism by which lymph node stromal cells regulate peripheral immunity.

OP0256 Changes of Microrna Expression in Lymph Node Stromal Cells of Rheumatoid Arthritis Patients

2014 ◽  
Vol 73 (Suppl 2) ◽  
pp. 158.2-158
Author(s):  
C. Ospelt ◽  
J. Hähnlein ◽  
R.E. Gay ◽  
P.P. Tak ◽  
D.M. Gerlag ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Lymph Node ◽  
Stromal Cells ◽  
Microrna Expression ◽  
Lymph Node Stromal Cells

scholarly journals Lymph Node Stromal Cells Generate Antigen-Specific Regulatory T Cells and Control Autoreactive T and B Cell Responses

Cell Reports ◽  
2020 ◽  
Vol 30 (12) ◽  
pp. 4110-4123.e4 ◽  
Author(s):  
Reza Nadafi ◽  
Catarina Gago de Graça ◽  
Eelco D. Keuning ◽  
Jasper J. Koning ◽  
Sander de Kivit ◽  
...  
Keyword(s):  
T Cells ◽  
Lymph Node ◽  
Regulatory T Cells ◽  
B Cell ◽  
Stromal Cells ◽  
Cell Responses ◽  
B Cell Responses ◽  
And Control ◽  
Lymph Node Stromal Cells
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