AB0928 CORONARY ARTERY LESIONS AT PRESENTATION IN KAWASAKI DISEASE: A MARKER OF IVIG RESISTANCE?A RETROSPECTIVE STUDY FROM NORTH INDIA

Abstract Objectives Kawasaki disease (KD) is an acute systemic vasculitis of unknown aetiology that affects infants and young children. Recent reports of elevated serum high mobility group box 1 (HMGB1) level during the acute phase of KD and its relationship to poor response to IVIG treatment suggest a possible association of HMGB1 polymorphisms with KD. We investigated the association between the polymorphisms of the HMGB1 gene, KD susceptibility, coronary artery lesions, and KD response to IVIG treatment. Methods Whole genome sequencing of the HMGB1 gene was performed to identify causative variants. Two tagging single nucleotide polymorphisms of the HMGB1 gene were selected using linkage disequilibrium analysis. The tagging single nucleotide polymorphisms were genotyped using the TaqMan Allelic Discrimination assay in a total of 468 subjects (265 KD patients and 203 controls). Results The HMGB1 single nucleotide polymorphisms were not associated with KD susceptibility. However, in KD patients, there was a significant association of rs1412125 with coronary artery lesions formation in the recessive model (GG vs AA + GA: odds ratio = 4.98, 95% CI = 1.69–14.66, P = 0.005). In addition, rs1412125 was associated with IVIG resistance in the recessive (GG vs AA + GA: odds ratio = 4.11, 95% CI = 1.38–12.23, P = 0.017) and allelic models (G vs A: odds ratio = 1.80, 95% CI = 1.06–3.06, P = 0.027). Conclusion The rs1412125 in HMGB1 might be a risk factor for the development of coronary artery lesions and IVIG resistance in KD patients.

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Structure equation model and neural network analyses to predict coronary artery lesions in Kawasaki disease: a single-centre retrospective study

Scientific Reports ◽

10.1038/s41598-020-68657-0 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Junji Azuma ◽

Takehisa Yamamoto ◽

Motoaki Nitta ◽

Yasuhiro Hasegawa ◽

Eri Kijima ◽

...

Keyword(s):

Neural Network ◽

Retrospective Study ◽

Coronary Artery ◽

Kawasaki Disease ◽

Equation Model ◽

Structure Equation ◽

Coronary Artery Lesions ◽

Single Centre ◽

Network Analyses ◽

Structure Equation Model

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Sonographic Gallbladder Abnormality Is Associated with Intravenous Immunoglobulin Resistance in Kawasaki Disease

The Scientific World JOURNAL ◽

10.1100/2012/485758 ◽

2012 ◽

Vol 2012 ◽

pp. 1-5 ◽

Cited By ~ 13

Author(s):

Chih-Jen Chen ◽

Fu-Chen Huang ◽

Mao-Meng Tiao ◽

Ying-Hsien Huang ◽

Li-Yan Lin ◽

...

Keyword(s):

Coronary Artery ◽

Kawasaki Disease ◽

Clinical Features ◽

Demographic Data ◽

Laboratory Data ◽

Ivig Treatment ◽

Coronary Artery Lesions ◽

Abdominal Sonography ◽

Ivig Resistance ◽

Group B

Objective. Kawasaki disease (KD) is an acute systematic vasculitis in children which causes coronary arterial lesions and hydrops of gallbladder. Our objective is to correlate the clinical significance and influence on disease outcome of patients with gallbladder abnormalities in Kawasaki dissease.Methods. Children who met KD diagnosis criteria and were admitted for IVIG treatment were retrospectively enrolled for analysis. Patients with abdominal sonography were divided into 2 groups based on the absence (Group A,N=61) or presence (Group B,N=16) of gallbladder abnormalities (GBA), defined as hydrops or acalculous cholecystitis. Between the two groups, clinical features, demographic data (including admission days, coronary artery lesions, IVIG resistance), and laboratory data before/after IVIG treatment were collected for analysis.Results. The presence of sonographic gallbladder abnormalities is correlated with higher levels of serum CRP, GPT, and neutrophils. It also points to an increased number of IVIG resistance rates in group B. There was no significant statistical difference among clinical features, age, gender, admission days, or coronary artery lesions between the two groups.Conclusion. Sonographic gallbladder abnormalities are associated with higher CRP, GPT, neutrophil and IVIG resistance in KD. It can be used as a predictor of IVIG resistance in patients with KD.

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Association of Thrombomodulin Gene C1418T Polymorphism with Susceptibility to Kawasaki Disease in Chinese Children

Disease Markers ◽

10.1155/2018/1064380 ◽

2018 ◽

Vol 2018 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

Yapeng Lu ◽

Rui Liu ◽

Luting Zha ◽

Shan Yuan ◽

Lang Tian ◽

...

Keyword(s):

Coronary Artery ◽

High Risk ◽

Kawasaki Disease ◽

Protein C ◽

Systemic Vasculitis ◽

Vascular Diseases ◽

Healthy Children ◽

Coronary Artery Lesions ◽

Ivig Resistance ◽

Anticoagulant System

Kawasaki disease (KD) is an acute systemic vasculitis that predominantly affects children and can result in coronary artery lesions (CALs). Thrombomodulin (TM) is a critical cofactor in the protein C anticoagulant system. The TM C1418T (rs1042579) polymorphism is associated with a high risk of cardiac-cerebral vascular diseases. But the association of the TM C1418T polymorphism with susceptibility to KD, CAL formation, and intravenous immunoglobulin (IVIG) resistance is still unclear. In our study, we examined the TM C1418T polymorphism in 122 children with KD and 126 healthy children and revealed the correlation between the TM C1418T polymorphism and KD, CAL formation, and IVIG resistance.

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