SAT0269 THE IMPACT OF SMOKING ON NAILFOLD MICROANGIOPATHY AND AUTOANTIBODY STATUS IN MALE AND FEMALE PATIENTS WITH SYSTEMIC SCLEROSIS

Abstract BackgroundPapillary thyroid carcinoma (PTC) is the main pathological type of thyroid carcinoma (TC). Gender is a prominent background parameter for patients with PTC. Here, we aimed to delineate the differences in cell clusters and immune microenvironment in relation to gender in PTC.ResultsMalignant epithelial cells were divided into two distinct subsets in male and female patients with PTC. Moreover, significant differences involving copy-number variations (CNVs), gene profiles, and cell differentiation were detected between male and female patients. Regarding the interactions of fibroblasts and endothelial cells with malignant epithelial cells, members of the human leukocyte antigen (HLA) family and their receptors were considered as typical in female patients with PTC, while transforming growth factor beta 1 (TGFB1) and its receptors were typical of male patients with PTC. The characteristics of B cells, including cell clusters, cell differentiation, and dominant gene sets, were significantly different between genders. ConclusionsOur data revealed the detailed differences in cell clusters and immune microenvironment in PTC according to gender at the single-cell level, which provided new insights into the understanding of the impact of gender on PTC.

Download Full-text

The impact of sexual dysfunction on quality of life in male and female patients with musculoskeletal disorders

Journal of Men s Health ◽

10.1016/j.jomh.2011.08.035 ◽

2011 ◽

Vol 8 (3) ◽

pp. 218-219

Author(s):

A. Triantafyllou ◽

E. Gavriilaki ◽

G. Triantafyllou ◽

P. Anyfanti ◽

A. Pyrpasopoulou ◽

...

Keyword(s):

Quality Of Life ◽

Sexual Dysfunction ◽

Musculoskeletal Disorders ◽

Male And Female ◽

Female Patients ◽

The Impact

Download Full-text

Comparing Sex-Specific Outcomes After Medial Patellofemoral Ligament Reconstruction for Patellar Instability: A Systematic Review

Orthopaedic Journal of Sports Medicine ◽

10.1177/23259671211058170 ◽

2021 ◽

Vol 9 (11) ◽

pp. 232596712110581

Author(s):

A.J. Fancher ◽

A.J. Hinkle ◽

M.L. Vopat ◽

K. Templeton ◽

A. Tarakemeh ◽

...

Keyword(s):

Systematic Review ◽

Systematic Reviews ◽

Patellar Instability ◽

Ligament Reconstruction ◽

Medial Patellofemoral Ligament ◽

Cochrane Library ◽

Male And Female ◽

Female Patients ◽

Secondary Purpose ◽

The Impact

Background: The impact of patient sex on outcomes after medial patellofemoral ligament ligament reconstruction (MPFLR) has not been well studied. Purpose: To conduct a systematic review to determine sex-based differences in outcomes after MPFLR for patellar instability and the proportion of studies examining this as a primary or secondary purpose. Study Design: Systematic review; Level of evidence, 4. Methods: A systematic review was performed using the PubMed, Cochrane Library, PubMed Central, Ovid, and Embase databases according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Studies were included if they were written in English, were performed on humans, consisted of patients who underwent MPFLR with allograft or autograft, evaluated at least 1 of the selected outcomes comparing male and female patients, and had statistical analysis available for relevant findings. Excluded were case reports, review studies or systematic reviews, studies that did not evaluate at least 1 sex-specific outcome, studies that included other injuries associated with patellofemoral instability injury, cadaveric studies, and those in which patients underwent concomitant procedures. Results: The initial search yielded 3470 studies; 2647 studies remained after removing duplicates. Of the 401 studies that underwent full-text review, 10 met all inclusion criteria and were included for quantitative analysis. A meta-analysis could not be performed given the heterogeneity within the data set. Of the 2647 studies evaluated in this study, only 2 (0.08%) studies examined the impact of patient sex on MPFLR outcomes as a primary purpose and only 8 (0.30%) studies explored it as a secondary purpose. Conclusion: Only 0.38% of the articles compared outcomes between male and female patients after MPFLR. The limited data available were too heterogenous to draw any concrete conclusions about the impact of patient sex on outcomes after MPFLR. Further research in this area is warranted, as findings may influence treatment plans and improve patient outcomes.

Download Full-text

The impact of Diabetes Mellitus on Lower urinary tract symptoms (LUTS) in both male and female patients

Diabetes & Metabolic Syndrome Clinical Research & Reviews ◽

10.1016/j.dsx.2018.11.009 ◽

2019 ◽

Vol 13 (1) ◽

pp. 454-457 ◽

Cited By ~ 1

Author(s):

Efstathios Papaefstathiou ◽

Kyriakos Moysidis ◽

Pavlos Sarafis ◽

Evaggelos Ioannidis ◽

Konstantinos Hatzimouratidis

Keyword(s):

Diabetes Mellitus ◽

Urinary Tract ◽

Lower Urinary Tract Symptoms ◽

Lower Urinary Tract ◽

Male And Female ◽

Female Patients ◽

Urinary Tract Symptoms ◽

The Impact ◽

Lower Urinary

Download Full-text

The Impact of Minimally Invasive Pituitary Surgery on Male and Female Sexual Dysfunction in Patients with Pituitary Adenoma

Urologia Internationalis ◽

10.1159/000517289 ◽

2021 ◽

pp. 1-7

Author(s):

Aydin Talat Baydar ◽

Ali Yasin Ozercan ◽

Denizhan Divanlioglu ◽

Zeynep Daglar ◽

Melih Balci ◽

...

Keyword(s):

Pituitary Adenoma ◽

Sexual Dysfunction ◽

Minimally Invasive ◽

Sexual Function ◽

Pituitary Adenomas ◽

Female Sexual Dysfunction ◽

Pituitary Surgery ◽

Male And Female ◽

Female Patients ◽

The Impact

Introduction: In the present study, we prospectively investigated the impact of endoscopic transnasal trans-sphenoidal surgery (ETTS) on sexual function in male and female patients with pituitary adenoma. Methods: The study included a total of 40 consecutive patients (male, n = 28 and female, n = 12) aged 22–65 years, who underwent ETTS for pituitary adenoma in our center between March 2019 and August 2019. Twenty-seven (67.5%) and 13 (32.5%) patients had functioning and nonfunctioning pituitary adenomas, respectively. Routine preoperative hormone levels were obtained in every patient. The tests were repeated at the postoperative third month. Preoperatively and at the postoperative third month, the 5-item version of the International Index of Erectile Function and the Female Sexual Function Index (FSFI) was used in male and female patients, respectively. Results: Before surgery, 24 (85.7%) men had erectile dysfunction (ED), and 10 (83%) women had female sexual dysfunction. After surgery, all the patients’ abnormal hormone parameters improved. All the male patients’ ED degrees were positively affected by surgery. In women, the FSFI was significantly better than in the preoperative period. Discussion/Conclusion: Our results showed that both males and females with pituitary adenomas benefitted from minimally invasive pituitary surgery in terms of a high-remission rate and improvement in sexual dysfunction.

Download Full-text