scholarly journals FRI0181 ORGAN DAMAGE FREE SURVIVAL IN SOUTHERN CHINESE PATIENTS WITH ACTIVE LUPUS NEPHRITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 674.1-674
Author(s):  
C. C. Mok ◽  
C. S. Sin ◽  
K. C. Hau ◽  
T. H. Kwan
Keyword(s):  
Lupus Nephritis ◽  
Regression Model ◽  
Cox Regression ◽  
Organ Damage ◽  
Renal Survival ◽  
Cox Regression Model ◽  
Free Survival ◽  
Renal Response

Background:The goals of treatment of lupus nephritis (LN) are to induce remission, retard the progression of chronic kidney disease, prevent organ complications and ultimately reduce mortality. Previous cohort studies of LN have mainly focused on the risk of mortality and development of end stage renal failure (ESRF) (renal survival). The cumulative frequency of LN patients who survive without organ damage, which correlates better with the balance between treatment efficacy and toxicity, as well as quality of life, has not been well studied.Objectives:To study the organ damage free survival and its predictive factors in patients with active LN.Methods:Consecutive patients who fulfilled ≥4 ACR/SLICC criteria for SLE and with biopsy proven active LN between 2003 and 2018 were retrospectivey analyzed. Those with organ damage before LN onset were excluded. Data on renal parameters and treatment regimens were collected. Complete renal response (CR) was defined as normalization of serum creatinine (SCr), urine P/Cr (uPCR) <0.5 and inactive urinary sediments. Partial renal response (PR) was defined as ≥50% reduction in uPCR and <25% increase in SCr. Organ damage of SLE was assessed by the ACR/SLICC damage index (SDI). The cumulative risk of having any organ damage or mortality since LN was studied by Kaplan-Meier’s analysis. Factors associated with a poor outcome were studied by a forward stepwise Cox regression model, with entry of covariates with p<0.05 and removal with p>0.10.Results:273 LN patients were identified but 64 were excluded (organ damage before LN onset). 211 LN patients were studied (92% women; age at SLE 30.4±13.5 years; SLE duration at LN 1.9±3.1years). 47 (22%) patients had nephrotic syndrome and 60 (29%) were hypertensive. Histological LN classes was: III/IV±V (75.1%), I/II (7.8%) and pure V (17.1%) (histologic activity and chronicity score 7.0±4.2 and 1.8±1.5, respectively). Induction regimens were: prednisolone (33.1±17.5mg/day) in combination with intravenous cyclophosphamide (CYC) (21.4%; 1.0±0.2g per pulse), oral CYC (8.6%; 96.4±37.8mg/day), azathioprine (AZA) (14.3%; 78.6±25.2mg/day), mycophenolate mofetil (MMF) (22.8%; 1.9±0.43g/day) and tacrolimus (TAC) (17.1%; 4.3±1.1mg/day). After a follow-up of 8.6±5.4 years, 94(45%) patient developed organ damage (SDI≥1) and 21(10%) patients died. The commonest organ damage was renal (36.3%) and musculoskeletal (17.9%), and the causes of death were: infection (38.1%), malignancy (19.0%), cardiovascular events (9.5%) and ESRF complications (9.5%). At last visit, 114 (55%) patients survived without any organ damage. The cumulative organ damage free survival at 5, 10 and 15 years after renal biopsy was 73.5%, 59.6% and 48.3%, respectively. The 5, 10 and 15-year renal survival rate were 95.2%, 92.0% and 84.1% respectively. In a Cox regression model, nephritic relapse (HR 3.72[1.78-7.77]), proteinuric relapse (HR 2.30[1.07-4.95]) and older age (HR 1.89[1.05-3.37]) were associated with either organ damage or mortality, whereas CR (HR 0.25[0.12-0.50]) at month 12 were associated with organ damage free survival. Baseline SCr, uPCR and histological LN classes were not significantly associated with a poor outcome. Among patients with class III/IV LN, the long-term organ damage free survival were not significantly different in users of MMF (reference) from CYC (IV/oral) (HR 1.45[0.76- 2.75]) or TAC (HR 1.03[0.26-1.62]) as induction therapy.Conclusion:Organ damage free survival is achieved in 55% of patients with active LN upon 9 years of follow-up. CYC/MMF/TAC based induction regimens did not differ for the long-term outcome of LN. Targeting complete renal response and preventing renal relapses remain important goals of LN treatment.Acknowledgments:NILDisclosure of Interests:None declared

The Effect of Chemotherapy Shortage in Iraq during the United Nations (UN) Sanctions on Outcome of Children with Acute Lymphocytic Leukemia (ALL).

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 3317-3317
Author(s):  
Haydar Frangoul ◽  
Mazin F. Al-Jadiry ◽  
Yu Shyr ◽  
Bashar Shakhtour ◽  
Salma A. Al-Hadad
Keyword(s):  
Regression Model ◽  
Cox Regression ◽  
Disease Free Survival ◽  
Dose Intensity ◽  
Diagnostic Tools ◽  
Cox Regression Model ◽  
Free Survival ◽  
Chemotherapy Drugs ◽  
Disease Free

Abstract There was an increase in childhood mortality in Iraq following the UN sanctions in 1990. The sanctions created a widespread shortage of medications, particularly chemotherapy drugs. We examined the effect of chemotherapy shortage on outcome of ALL in Iraqi children. Between 1990 and 2002, 670 children with ALL were treated at Children Welfare Teaching Hospital in Baghdad. Detailed records were available for review, including documentation of missed doses of chemotherapy and reason(s) for missing it. Excluded from the analysis were patients who refused or discontinued therapy or were lost to follow up prior to the completion of therapy. ALL risk classification analysis was based on the NCI risk grouping; children were treated per the UKALL X and XI (1990–1997) and MRC 97 (1998–2002) protocols. Therapy consisted of 4 phases: induction, consolidation/interim maintenance, intensification and maintenance. Drug shortage was defined as decrease or elimination of medication solely due to unavailability of medication, and not due to myelosuppression or other toxicities. Because compliance with oral medications is subjective, our analysis was limited to intravenous medication during the first 3 phases of therapy. A Cox regression model was used to examine variables associated with outcome. There were 413 patients with standard risk (SR) disease with a median age of 4.9 years (range 1.08–9.83) and median presenting WBC of 9050 (range 400–47000), and 257 with high risk disease (HR) with a median age of 8 years (range 1.3–15) and median presenting WBC of 79300 (range 800–600000). Diagnosis of ALL was based on microscopic examination and cytochemical stains; cytogenetics and flow cytometry were not available. The median follow up for all patients is 4.8 years. For SR patients the disease free survival (DFS) and survival at 5 years are 63% and 68% respectively. In Cox regression model SR patients who received ≤ 50% of prescribed chemotherapy during induction had a significantly worse DFS (RR 0.494, 95% CI 0.30 to 0.814; p=0.0058). For HR patients the disease free survival (DFS) and survival at 5 years are 49% and 53% respectively. For HR patients those who received ≤ 50% of prescribed chemotherapy during consolidation/interim maintenance had a significantly worse DFS (RR 0.45, 95% CI 0.2018 to 1.0253; p= 0.057). Overall survival (OS) of patients who did not miss any chemotherapy due to shortage in the first 3 phases of therapy was superior in both SR (85% vs. 63%, p=0.0038) and HR patients (72% vs. 49% p= 0.018) at 5 years. The OS of children who received all chemotherapy was significantly better than those who missed any chemotherapy due to shortage at 5 years (81% vs. 58%) (p=0.0002). Despite the limited supportive care and diagnostic tools during the UN sanctions, Iraqi children who were able to receive all their intravenous chemotherapy had comparable outcome to that described in developed countries. These results suggest that dose intensity of chemotherapy is most important during induction for SR patients and during consolidation/interim maintenance therapy for HR patients.

scholarly journals Prosthetic complications of fixed dental prostheses supported by locking-taper implants: A retrospective study with a mean follow-up of 5 years.

2021 ◽  
Author(s):  
Wen Mo Gao ◽  
Wei Geng ◽  
Chen Chen Luo
Keyword(s):  
Retrospective Study ◽  
Bone Loss ◽  
Regression Model ◽  
Protective Factor ◽  
Cox Regression ◽  
Marginal Bone Loss ◽  
Cox Regression Model ◽  
Prosthetic Complications ◽  
Free Rate

Abstract Background: Restoration with locking-taper implants is a widely used methodology. However, relatively few have examined conical connection systems like locking-taper implant systems. This study provides a retrospective study of locking-taper fixed restorations, mainly focused on prosthetic complications.Methods: All patients who underwent conical connected implants from 2008–2010 were examined. Preparation of the implant sites was performed according to the standard procedures for the Bicon system. The bone healing took over 6 months, and the prosthetic procedure was initiated thereafter. Integrated abutment crowns or gold porcelain crowns were used, and the prosthesis type was a single crown or a fixed dental prosthesis. Once the crown was in place, its occlusion was thoroughly checked and adjusted, and then the crown was glazed or finely polished. The Kaplan-Meier method was used to calculate the cumulative complication-free rates for 5 and 10 years. Additionally, a Cox regression model was used to identify the factors that independently influenced the results. Implant survival and marginal bone loss were also investigated.Results: A total of 392 patients who underwent 541 implants and 434 locking taper implant-based restorations from 2008–2010 were examined. The overall 5-year cumulative complication-free rate was 83.34%. The most common prosthetic complication was veneer chipping, with a frequency of 67.53%. According to the Cox regression model, the complication-free rate of integrated abutment crowns was significantly higher than gold porcelain crowns, molar regions was significantly higher than premolar regions, and females was significantly higher than males. Only three implant failures happened, and a mean marginal bone loss at 1- year, 5-year and 10- year was 0.25mm（95%CI：±0.12）, 0.40mm （95%CI：±0.03）and 0.51mm（95%CI：±0.05）, respectively.Conclusion: Veneer chipping was the most common complication with locking-taper implants supported fixed restorations. According to the result of Cox regression model, gold porcelain crowns are a protective factor relative to integrated abutment crowns, male sex is a protective factor relative to female sex, and premolar prosthetics are a protective factor relative to molar prosthetics. The long-term clinical effect of locking-taper implant is stable, and the implant success rate can meet the clinical needs. The bone tissue level around the implant can maintain long-term stability.

P2619Combined evaluation of nutrition screening indexes on long-term mortality in patients hospitalized for acute heart failure

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
Y Kenichiro ◽  
M Oguri ◽  
K Takahara ◽  
T Sumi ◽  
H Takahashi ◽  
...  
Keyword(s):  
Heart Failure ◽  
Body Mass Index ◽  
Regression Model ◽  
Body Mass ◽  
Cox Regression ◽  
Cox Regression Model ◽  
Predictive Values ◽  
Conut Score ◽  
Long Term Mortality

Abstract Background Along with an aging society, the global burden of heart failure (HF) is evident in Japan. Recent reports showed that malnutrition is one of the frequent comorbidity in patients with HF, and this grievous issue is related to worsening prognosis in such subjects. There are many screening tools of nutrition risks, however, feasible indexes or strategies for evaluating nutrition risk in patients with HF remain to be identified definitively. Purpose The purpose of the present study was to examine the effectiveness of various nutrition indexes on 3-year mortality in hospitalized acute HF patients. Methods The study population comprised a total of 817 individuals who were hospitalized for acute HF between November 2009 and December 2015, and was followed up for 3 years. All the previously established objective nutritional indexes [The controlling nutritional status (CONUT) score, geriatric nutritional risk index (GNRI), and subjective global assessment (SGA)] were evaluated at the time of hospital admission. Malnutrition status of each index was defined as CONUT score ≥5, GNRI <91, or SGA (B and C), respectively. We evaluated combined predictive values of these indexes for 3-year mortality by Cox regression model, and calculated the net reclassification improvement (NRI) and the integrated discrimination improvement (IDI). Results The median age was 79 (interquartile range 70–85) years, and 55.7% of the subjects were male. The frequency of malnutrition was 18.1% in CONUT score, 31.9% in GNRI, and 25.9% in SGA. The rate of 3-year mortality was 32.2%. All indexes were related to the occurrence of 3-year mortality by univariate analyses (P<0.001). We examined combined predictive values by calculating multivariable-adjusted hazard ratios (aHR) and 95% confidence intervals (CI) for associations of malnutrition by these 3 indexes and prognostic variables identified by multivariable Cox regression model (age, body mass index, systolic blood pressure, reduced eGFR, albumin, and prior HF hospitalization). Malnutrition of all 3 indexes (5.6% of the subjects) was associated with higher relative risk of 3-year mortality than well-nutrition (aHR 1.90; 95% CI 1.07–3.35, P=0.028), or malnutrition of any 1 index (aHR 1.95; 95% CI 1.18–3.21, P=0.009). Next, we individually included each value into a reference model (age, body mass index, reduced eGFR, albumin, prior HF hospitalization, and ischemic etiology by multivariable logistic regression analysis with P<0.05). SGA was superior according to comprehensive discrimination, calibration, and reclassification analysis (NRI 0.212, P=0.003; IDI 0.005, P=0.029). Similar analysis with other indexes (CONUT score or GNRI) revealed no improvement. Conclusion Our present results suggest that simultaneous addition of CONUT, GNRI, and SGA seems useful for predicting long-term mortality in acute HF. In addition, nutritional screening with SGA independently improves mortality risk stratification.

scholarly journals Psychiatric Disorders in Female Psychosexual Disorders—A Nationwide, Cohort Study in Taiwan

2021 ◽  
Author(s):  
Iau-Jin Lin ◽  
Nian-Sheng Tzeng ◽  
Chi-Hsiang Chung ◽  
Chien Wu-chien
Keyword(s):  
Health Insurance ◽  
Regression Model ◽  
Psychiatric Disorders ◽  
Mental Health Problems ◽  
Cox Regression ◽  
Geographic Region ◽  
Research Database ◽  
Cox Regression Model ◽  
Urbanization Level

Abstract We aimed to investigate whether females with psychosexual disorders were associated with the risk of affective and other psychiatric disorders. A total of 2,240 enrolled individuals, with 560 patients with psychosexual disorders and 1,680 subjects without psychosexual disorders (1:3) matched for age and index year, from the Longitudinal Health Insurance Database, retrieved from the National Health Insurance Research Database (NHIRD), between 2000-2015 in Taiwan. The multivariate Cox regression model was used to compare the risk of developing psychiatric disorders during the 15 years of follow-up. There were 98 in the cohort with psychosexual disorders (736.07 per 100,000 person-year) and 119 in the non-cohort without psychosexual disorders (736.07 per 100,000 person-year) that developed psychiatric disorders. The multivariate Cox regression model revealed that the adjusted hazard ratio (HR) was 9.848 (95% CI= 7.298 — 13.291, p < 0.001), after the adjustment of age, monthly income, urbanization level, geographic region, and comorbidities. Female patients with psychosexual disorders were associated with the risk of psychiatric disorders. This finding could be a reminder for clinicians about the mental health problems in patients with psychosexual disorders.

scholarly journals Long Term Outcome Prediction in Stemi/Nstemi Patients By Means of the Model Consisting of Simple Clinical Parameters

2021 ◽  
Vol 8 (3) ◽  
pp. 159-170
Author(s):  
Paweł Korczyc ◽  
Jędrzej Chrzanowski ◽  
Arkadiusz Stasiak ◽  
Joanna Stasiak ◽  
Andrzej Bissinger ◽  
...  
Keyword(s):  
Regression Model ◽  
Cox Regression ◽  
Everyday Practice ◽  
Syntax Score ◽  
Clinical Parameters ◽  
Observation Study ◽  
Cox Regression Model ◽  
Long Term Outcome ◽  
The Impact

Aim: Our study aimed to identify the clinical variables associated with long-term mortality after MI and to construct a simple, easy to use clinical practice model for the prediction of 5 year mortality after MI. Material and Methods: This is a prospective 5-year observation study of MI patients admitted to the Department of Cardiology at the Copernicus Memorial Hospital in Lodz in 2010 and 2011. The data were collected during hospitalization and again after a period of 1 and 5 years. A multi-factor multi-level Cox regression model was constructed to investigate the impact of clinical factors on long-term survival.results: 92 patients (39 STEMI, 53 NSTEMI) were included in the study and their data were used to construct a Cox regression model with satisfactory fit (R 2 =0.7945). Factors associated with a decrease in 5-year risk are: age (1.06, 95%CI: 1.01-1.11), SYNTAX score (1.05, 95%CI: 1.02-1.08), WBC level (1.16, 95%CI: 1.08-1.26), and glycemia at enrollment (1.01, 95%CI: 1.01-1.01). Higher values of HDL at enrollment were associated with a decrease in 5-year risk (HR=0.97, 95%CI: 0.93-0.99).conclusion: The model we created is a valuable tool that is useful and easy to employ in everyday practice for assessing the 5-year prognosis of patients after MI. What is new: The study presents the new model for prediction of 5-year mortality after myocardial infarction. This model is based on simple clinical parameters and may by applied in everyday practice.

Gene-Expression for Prediction of Disease Progression Following Initial Management of Follicular Lymphoma

Blood ◽  
2015 ◽  
Vol 126 (23) ◽  
pp. 4804-4804
Author(s):  
Etienne Mahe ◽  
Ariz Akhter ◽  
Danielle H. Oh ◽  
Fahad Farooq ◽  
Meer-Taher Shabani-Rad ◽  
...  
Keyword(s):  
Follicular Lymphoma ◽  
Regression Model ◽  
Disease Progression ◽  
Cox Regression ◽  
Tumor Grade ◽  
Age At Diagnosis ◽  
P Value ◽  
Cox Regression Model ◽  
Cox Regression Analysis

Abstract Introduction Patients with advanced staged Follicular Lymphoma (FL) are initially managed with either immediate chemoimmunotherapy (CI) or "watchful waiting" (WW) depending on clinical symptoms, tumor burden, and organ compromise. Clinicians currently predict time to progression (TTP) using the Follicular Lymphoma International Prognostic Index (FLIPI) score. Well-defined & validated molecular techniques capable of additional predictive power are lacking, however. We hypothesized that gene-expression (GE) data, employing an evidence-based feature set, might assist in the upfront stratification of FL patients. Objectives 1 Identify genes whose GE has previously been identified as relevant to FL 2 Perform GE testing on an series of FL cases, classified by upfront intervention, using this custom gene feature set 3 Identify the gene(s) most strongly predictive of disease progression in each of the clinical classes (i.e. CI vs. WW) 4 Compare the performance of GE data to other prognostic parameters Methods We performed a search of MEDLINE-indexed studies reporting FL GE results. We input all available appertaining data into NVIVO (v10), in which a computer-assisted search for GE features was performed. This list, after refinement, formed the basis of a custom NanoString codeset. We used the MD Anderson Microarray Sample Size Calculator for sample size estimation and retrieved FL cases from our regional archives; those cases with sufficient tissue were organized by upfront treatment approach and available clinical data recorded (age at diagnosis, sex, stage, grade, FLIPI scores & TTP). TTP was defined as time in months either to diagnosed disease progression or, in the WW group, first CI-based treatment. After pathology review, RNA was isolated using standard protocols. GE data was analyzed using gene-specific receiver-operating characteristic analysis, ranking performed according to the area-under-the-curve (MATLAB v 8.3.0.532). Validation against TTP using Cox-regression was then performed (SPSS v22); p < 0.05 was considered significant. Results Our MEDLINE search yielded 713 publications; after refinement, our NVIVO analysis suggested 282 valid gene features. Review of local FL cases accessioned between 2004 & 2012 was performed; this period ensured uniform follow-up and CI treatment strategies for all FL patients. Patients were classified as WW (68 patients) & CI (98 patients), and then sub-classified as WW1 (WW without need for CI over the follow-up interval; 23 patients) and WW2 (WW requiring CI in the follow-up interval; 45 patients) and CI1 (CI without disease progression over the follow-up interval; 61 patients) and CI2 (CI with disease progression; 37 patients). Median follow-up time was 60 months in the WW group and 56 months in the CI group (Mann-Whitney p = 0.177). With the exception of FLIPI score in the WW class (higher on average in the WW2 sub-class), no other clinical factor differed significantly between the sub-classes. GE analyses suggested that ACTB in the WW group and MEK1 in the CI group might be most predictive of TTP. Table 1. TTP results by Cox-regression analysis for the WW group WW Variable Cox-Regression Model Co-efficient p-value Cox-Regression Model Linear Co-efficient 95% CI Age at diagnosis 0.56 0.98-1.04 Sex 0.34 0.67-3.19 Tumor Grade 0.41 0.40-9.48 Tumor Stage 0.54 0.69-2.04 FLIPI Score 0.06 0.97-3.6 ACTB Expression 0.006 1.4-7.74 Table 2. TTP results by cox-regression analysis for the CI group CI Variable Cox-Regression Model Co-efficient p-value Cox-Regression Model Linear Co-efficient 95% CI Age at diagnosis 0.34 0.99-1.04 Sex 0.96 0.48-2.16 Tumor Grade 0.92 0.43-2.13 Tumor Stage 0.17 0.874-2.11 FLIPI Score 0.4 0.47-1.35 MEK1 Expression 0.011 0.19-0.81 Conclusions To our knowledge, we have performed the first GE analysis of FL cases classified by intervention, and have identified GE features predictive of disease progression or requirement of intervention (as in the WW group). In the CI group, identification of MEK1 as a major prognostic player echoes previous work studying the MAP-kinase pathway in FL. In the WW group, however, identification of ACTB as a potential prognostic player is a novel observation requiring validation, especially since this gene is ubiquitously expressed across multiple cell types. Figure 1. WW TTP, stratified by ACTB expression Figure 1. WW TTP, stratified by ACTB expression Figure 2. CI TTP, stratified by MEK1 expression Figure 2. CI TTP, stratified by MEK1 expression Disclosures No relevant conflicts of interest to declare.

scholarly journals Posttransplant Anemia as a Prognostic Factor of Mortality in Kidney-Transplant Recipients

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Maria Majernikova ◽  
Jaroslav Rosenberger ◽  
Lucia Prihodova ◽  
Miriam Jarcuskova ◽  
Robert Roland ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Transplantation ◽  
Prognostic Factor ◽  
Regression Model ◽  
Cox Regression ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Cox Regression Model ◽  
Risk Of Mortality

Background.Findings on the association between posttransplant anemia (PTA) and mortality in posttransplant patients are scarce. This study explored whether PTA shortly after kidney transplantation (KT) predicts mortality at up to 10 years’ follow-up, stratified for chronic kidney disease (CKD) stages.Methods.PTA was divided into 3 categories according to the hemoglobin (Hb) value: severe (Hb < 10 g/dl), mild (10.0 g/dl ≤ Hb < 11.9 g/dl), or no PTA (Hb ≥ 12 g/dl). CKD stages were estimated using the CKD-EPI formula and divided into 2 groups: CKD1-2 and CKD3–5. Cox regression, stratified according to CKD, was performed to identify whether different categories of PTA predicted mortality in KT recipients.Results.Age, being female, and both mild and severe PTA contributed significantly to the Cox regression model on mortality in CKD1-2. In the Cox regression model for mortality in CKD3–5, age and severe PTA contributed significantly to this model.Conclusion.PTA shortly after KT increased the risk of mortality at up to 10 years’ follow-up. Even mild PTA is associated with a 6-fold higher risk of mortality and severe PTA with a 10-fold higher risk of mortality in CKD1-2. Clinical evaluation and treatment of anemia might reduce the higher risk of mortality in patients with PTA in early stages of CKD after KT.

scholarly journals Prosthetic complications of fixed dental prostheses supported by locking-taper implants: a retrospective study with a mean follow-up of 5 years

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Wen mo Gao ◽  
Wei Geng ◽  
Chen chen Luo
Keyword(s):  
Bone Loss ◽  
Regression Model ◽  
Cox Regression ◽  
Marginal Bone Loss ◽  
Cox Regression Model ◽  
Fixed Dental Prosthesis ◽  
Single Crown ◽  
Prosthetic Complications ◽  
Free Rate

Abstract Background Restoration with locking-taper implants is a widely used methodology. However, conical connection systems such as locking-taper implant systems have rarely been examined. This study provides a retrospective investigation of locking-taper fixed restorations, mainly focusing on prosthetic complications. Methods Patients undergo treatment with conical connected implants from 2008 to 2010 were examined. Preparation of the implant sites was performed according to the standard procedures for the Bicon system. Bone healing took over 6 months, and the prosthetic procedure was initiated thereafter. Integrated abutment crowns or gold porcelain crowns were used, and the prosthesis type was a single crown or a fixed dental prosthesis. Once the crown was in place, its occlusion was thoroughly checked and adjusted, and then the crown was glazed or finely polished. The Kaplan–Meier method was used to calculate the cumulative complication-free rates for 5 and 10 years. Additionally, a Cox regression model was used to identify the factors that independently influenced the results. Implant survival and marginal bone loss were also investigated. Results A total of 392 patients who underwent 541 implants and 434 locking taper implant-based restorations from 2008 to 2010 were examined. The overall 5-year cumulative complication-free rate was 83.34%. The most common prosthetic complication was veneer chipping, with a frequency of 67.53%. According to the Cox regression model, the complication-free rate of integrated abutment crowns was significantly higher than that of gold porcelain crowns, that of molar regions was significantly higher than that of premolar regions, and that of females was significantly higher than that of males. Only three implant failures happened, and the mean marginal bone loss values at 1- year, 5-years and 10- years were 0.25 mm (95% CI ± 0.12), 0.40 mm (95% CI ± 0.03) and 0.51 mm (95% CI ± 0.05), respectively. Conclusion Veneer chipping was the most common complication with locking-taper implant-supported fixed restorations. The incidence of complications for IACs is significantly higher than that for GPCs. Age, location, and prosthesis type are not determinants of prosthetic complications. Besides, the long-term clinical effect of locking-taper implant can meet the clinical needs. The bone tissue level around the implant can maintain long-term stability.

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